Patents Assigned to Centaur Pharmaceuticals, Inc.
  • Process
    Patent number: 6689911
    Abstract: An integrated process for preparing &agr;-(2,4-disulfophenyl)-N-tert-butylnitrone and its salts is disclosed in which N-tert-butylhydroxylamine acid addition salt is incompletely neutralised so as to leave catalytic amounts of acid and the neutralisation product is condensed with an appropriate aldehyde.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: February 10, 2004
    Assignees: Centaur Pharmaceuticals, Inc., AstraZeneca AB
    Inventors: Henry Kruk, John McGinley, Sergei Pouhov, John Vajda, Allan Wilcox, Jörgen Blixt, Ulf Larsson
  • Aryl nitrone therapeutics and methods for treating inflammatory bowel disease
    Patent number: 6545056
    Abstract: Disclosed are methods for treating or preventing inflammatory bowel disease (IBD) using aryl nitrone compounds. Pharmaceutical compositions containing aryl nitrone compounds which are useful for the treatment or prophylaxis of IBD are also disclosed.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: April 8, 2003
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: William D. Flitter, William A. Garland, Beverly Greenwood Van-Meerveld, Ian Irwin
  • Acetamidobenzamide compounds for neurodegenerative disorders
    Patent number: 6509378
    Abstract: A group of benzamide compounds are disclosed which are useful for treating neurodegenerative disorders. Methods for making these compounds are provided. These materials are formed into pharmaceutical compositions for oral or intravenous administration to patients suffering from conditions such as Parkinson's disease which can exhibit themselves as progressive loss of central nervous system function. The compounds can arrest or slow the progressive loss of function.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: January 21, 2003
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: William Flitter, William Garland, Richard Paylor, Allan Wilcox
  • Amide therapeutics and methods for treating inflammatory bowel disease
    Patent number: 6486349
    Abstract: Disclosed are methods for treating or preventing inflammatory bowel disease (IBD) using amide and related compounds. Pharmaceutical compositions containing amide compounds which are useful for the treatment or prophylaxis of IBD are also disclosed.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: November 26, 2002
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: William D. Flitter, William A. Garland, Beverly Greenwood Van-Meerveld, Ian Irwin
  • Alpha-(4-Ethoxyphenyl)-N-tert-butylnitrone, pharmaceutical compositions and their medical use
    Patent number: 6441032
    Abstract: Disclosed are novel &agr;-aryl-N-alkylnitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compositions are useful as therapeutics for preventing and/or treating neurodegenerative, autoimmune and inflammatory conditions in mammals and as analytical reagents for detecting free radicals.
    Type: Grant
    Filed: August 9, 2000
    Date of Patent: August 27, 2002
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: Judith A. Kelleher, Kirk R. Maples, Alina Dykman, Yong-Kang Zhang, Allan L. Wilcox, Julian Levell
  • &agr;-aryl-N-alkylnitrones and pharmaceutical compositions containing the same
    Patent number: 6433008
    Abstract: Disclosed are novel aryl-N-alkylnitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compositions are useful as therapeutics for preventing and/or treating neurodegenerative, autoimmune and inflammatory conditions in mammals and as analytical reagents for detecting free radicals.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: August 13, 2002
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: Judith A. Kelleher, Kirk R. Maples, Alina Dykman, Yong-Kang Zhang, Allan L. Wilcox, Julian Levell
  • Furan nitrone compounds
    Patent number: 6376540
    Abstract: Disclosed are furan nitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compounds are useful as analytical reagents for detecting free radicals and as therapeutics for treating a wide variety of medical dysfunctions and diseases.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: April 23, 2002
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: Judith A. Kelleher, Kirk R. Maples, Lowell David Waterbury, Allan L. Wilcox, Hong Xu, Yong-Kang Zhang
  • 3,4,5-trisubstituted aryl nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation
    Patent number: 6342523
    Abstract: Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have the formula: where R1-R4 are as defined in the specification. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: January 29, 2002
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: L. David Waterbury, Allan L. Wilcox, John M. Carney, Farah Mavandadi, Albert Danielzadeh
  • Methods for preventing and treating autoimmune and inflammatory disease using thioether furan nitrone compounds
    Patent number: 6310092
    Abstract: Disclosed are methods for preventing the onset of autoimmune or inflammatory diseases in mammals using a pharmaceutical composition containing a pharmaceutically acceptable carrier and an effective amount of a thioether furan nitrone compound.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: October 30, 2001
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: Judith A. Kelleher, Kirk R. Maples, Yong-Kang Zhang
  • Amide therapeutics for the treatment of inflammatory bowel disease
    Patent number: 6271265
    Abstract: Disclosed are methods for treating or preventing inflammatory bowel disease (IBD) using amide and related compounds. Pharmaceutical compositions containing amide compounds which are useful for the treatment or prophylaxis of IBD are also disclosed.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: August 7, 2001
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: William D. Flitter, William A. Garland, Beverly Greenwood Van-Meerveld, Ian Irwin
  • Aryl nitrone therapeutics for the treatment of inflammatory bowel disease
    Patent number: 6258852
    Abstract: Disclosed are methods for treating or preventing inflammatory bowel disease (IBD) using aryl nitrone compounds. Pharmaceutical compositions containing aryl nitrone compounds which are useful for the treatment or prophylaxis of IBD are also disclosed.
    Type: Grant
    Filed: May 8, 2000
    Date of Patent: July 10, 2001
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: William D. Flitter, William A. Garland, Beverly Greenwood Van-Meerveld, Ian Irwin
  • Inhibition of angiogenesis
    Patent number: 6255353
    Abstract: Certain simple chemical agents, referred to herein as nitrone related therapeutics or “NRTs”, when administered to a patient susceptible to neovascularization (angiogenesis), can intervene and inhibit the disease's progress. Methods for therapeutically and prophylactically inhibiting angiogenesis by administering one or more NRTs are disclosed as are pharmaceutical compositions for use in such methods of treating. NRTs useful in these compositions and therapeutic methods are also disclosed.
    Type: Grant
    Filed: March 12, 1999
    Date of Patent: July 3, 2001
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: Lowell D. Waterbury, Kenneth W. Narducy, Allan L. Wilcox
  • &agr;-(2-hydroxyphenyl) nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation
    Patent number: 6197826
    Abstract: Disclosed are novel &agr;-(2-hydroxyphenyl) nitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.
    Type: Grant
    Filed: July 16, 1999
    Date of Patent: March 6, 2001
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: L. David Waterbury, John M. Carney, Allan L. Wilcox
  • Benzamide therapeutics for the treatment of inflammatory bowel disease
    Patent number: 6194465
    Abstract: Benzamides are disclosed to be useful for treating and preventing inflammatory bowel disease.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: February 27, 2001
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: William D. Flitter, William A. Garland, Ian Irwin
  • Benzamides for neurodegenerative disorder treatment
    Patent number: 6140369
    Abstract: A group of benzamide compounds are disclosed which are useful for treating neurodegenerative disorders. Methods for making these compounds are provided. These materials are formed into pharmaceutical compositions for oral or intravenous administration to patients suffering from conditions such as Parkinson's disease or Alzheimer's which can exhibit themselves as progressive loss of central nervous system function. The compounds can arrest or slow the progressive loss of function.
    Type: Grant
    Filed: September 7, 1999
    Date of Patent: October 31, 2000
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: William David Flitter, William A. Garland, Allan L. Wilcox, Richard E. Paylor
  • Opthalmic pharmaceutical compositions comprising a nitrone compound and methods for treating ocular inflammation using such compositions
    Patent number: 6140356
    Abstract: Ophthalmic pharmaceutical compositions containing a pharmaceutically acceptable ophthalmic carrier and an inflammation-treating amount of a nitrone compound are disclosed. Also disclosed are methods for treating ocular inflammation conditions, such as uveitis, using pharmaceutical compositions.
    Type: Grant
    Filed: September 20, 1999
    Date of Patent: October 31, 2000
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: Kenneth W. Narducy, Efraim Duzman, John Michael Carney, Allan Lee Wilcox
  • Methods for preventing and treating autoimmune and inflammatory diseases using thioether furan nitrone compounds
    Patent number: 6127408
    Abstract: Disclosed are methods for preventing and/or treating autoimmune and inflammatory diseases in mammals using a pharmaceutical composition containing a pharmaceutically acceptable carrier and an effective amount of a thiether furan nitrone compound.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: October 3, 2000
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: Judith A. Kelleher, Kirk R. Maples, Yong-Kang Zhang
  • Aryl nitrone therapeutics for the treatment of inflammatory bowel disease
    Patent number: 6083989
    Abstract: Disclosed are methods for treating or preventing inflammatory bowel disease (IBD) using aryl nitrone compounds. Pharmaceutical compositions containing aryl nitrone compounds which are useful for the treatment or prophylaxis of IBD are also disclosed.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: July 4, 2000
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: William D. Flitter, William A. Garland, Beverly Greenwood Van-Meerveld, Ian Irwin
  • Pharmaceutical compositions of acetamidobenzamide compounds for neurodegenerative disorders
    Patent number: 6077870
    Abstract: A group of benzamide compounds are disclosed which are useful for treating neurodegenerative disorders. Methods for making these compounds are provided. These materials are formed into pharmaceutical compositions for oral or intravenous administration to patients suffering from conditions such as Parkinson's disease which can exhibit themselves as progressive loss of central nervous system function. The compounds can arrest or slow the progressive loss of function.
    Type: Grant
    Filed: July 3, 1997
    Date of Patent: June 20, 2000
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: William Flitter, William Garland, Richard Paylor, Allan Wilcox
  • Acetamidobenzamide compounds for neurodegenerative disorders
    Patent number: 6066765
    Abstract: A group of benzamide compounds are disclosed which are useful for treating neurodegenerative disorders. Methods for making these compounds are provided. These materials are formed into pharmaceutical compositions for oral or intravenous administration to patients suffering from conditions such as Parkinson's disease which can exhibit themselves as progressive loss of central nervous system function. The compounds can arrest or slow the progressive loss of function.
    Type: Grant
    Filed: March 30, 1998
    Date of Patent: May 23, 2000
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: William Flitter, William Garland, Richard Paylor, Allan Wilcox