Abstract: The described invention provides an ex vivo dynamic multiple myeloma cancer niche contained in a pumpless perfusion culture device. The dynamic multiple myeloma cancer niche includes (a) a three-dimensional tissue construct containing a dynamic ex vivo bone marrow niche, which contains a mineralized bone-like tissue containing viable osteoblasts self-organized into cohesive multiple cell layers and an extracellular matrix secreted by the viable adherent osteoblasts; and a microenvironment dynamically perfused by nutrients and dissolved gas molecules; and (b) human myeloma cells seeded from a biospecimen composition comprising mononuclear cells and the multiple myeloma cells. The human myeloma cells are in contact with osteoblasts of the bone marrow niche, and the viability of the human myeloma cells is maintained by the multiple myeloma cancer niche.

Abstract: A method of purifying Extracellular Vesicle Capture by AnTibody of CHoice and Enzymatic Release (EV-CATCHER), designed for high-throughput analysis of low-abundance small-RNA cargos by next-generation sequencing, and use of this method for preparing purified populations of biological particles or cells from a biological sample for in vitro evaluation of a patient's risk of developing and for treating a severe viral infection; for enhancing therapeutic effectiveness of convalescent plasma therapy in a patient at risk for a severe coronavirus infection, and for treating a patient with a severe coronavirus infection, are described.

Abstract: The described invention provides an ex vivo dynamic multiple myeloma cancer niche contained in a pumpless perfusion culture device. The dynamic multiple myeloma cancer niche includes (a) a three-dimensional tissue construct containing a dynamic ex vivo bone marrow niche, which contains a mineralized bone-like tissue containing viable osteoblasts self-organized into cohesive multiple cell layers and an extracellular matrix secreted by the viable adherent osteoblasts; and a microenvironment dynamically perfused by nutrients and dissolved gas molecules; and (b) human myeloma cells seeded from a biospecimen composition comprising mononuclear cells and the multiple myeloma cells. The human myeloma cells are in contact with osteoblasts of the bone marrow niche, and the viability of the human myeloma cells is maintained by the multiple myeloma cancer niche.

Abstract: A retrofitable drive assembly attaches and detaches quickly, easily, and reversibly from a conventional, manually powered wheelchair and is employed to convert the manually powered wheelchair into an electrically powered wheelchair. The drive assembly includes a plurality of wheel troughs, each adjustably sizeable to receive therein a rear push wheel of the manually powered wheelchair, regardless of the wheelchair's size and its rear push wheels' dimensions. In addition, the drive assembly includes two drive wheels positioned towards a front end of the drive assembly and a single caster-wheel assembly positioned towards a rear end of the drive assembly.

Abstract: A table having multiple stations arranged about a central stationary table top. The stations are independently vertically adjustable to accommodate the individual needs of the users. Adjustment mechanisms are utilized to independently adjust the height of each station and are easily operated by persons with a wide range of physical capabilities. More than one adjustment mechanism may be utilized. There can be a minimum of two stations but the dimensions and shape of the table top may be chosen to enable any desired number of stations. The use of a central stationary table top with stations arranged thereabout provides for a common area on which to place shared items and materials. This table encourages interaction among the users while enabling each to adjust his or her station to an exact table height as needed. The stations may also have tilt capabilities to further accommodate the needs of the users.