Abstract: Practical assays to identify compounds that overcome the resistance of M. tuberculosis to bedaquiline are based on transcription factors Rv0324 and Rv0880 shown to mediate this resistance.
Type:
Grant
Filed:
January 6, 2017
Date of Patent:
November 12, 2019
Assignees:
Institute for Systems Biology, Center for Infectious Disease Research
Abstract: This invention relates to a prognostic method for determining the risk of an asymptomatic human subject with latent tuberculosis (TB) infection or apparent latent TB infection and/or after suspected exposure to TB progressing to active tuberculosis disease comprising the steps of quantifying and computationally analysing relative abundances of a collection of pairs of gene products (“TB biomarkers”) derived from a sample obtained from the subject. The invention further relates to a collection of TB biomarkers that generates a transcriptomic signature of risk for prediction of the likelihood of an asymptomatic human subject with latent TB infection and/or after suspected exposure to TB progressing to active tuberculosis disease. Furthermore, a kit comprising gene-specific primers or oligonucleotide probes for the detection of pairs of TB biomarkers that generates a prognostic signature of risk for use with the method of the invention is described.
Type:
Application
Filed:
November 9, 2016
Publication date:
August 15, 2019
Applicants:
UNIVERSITY OF CAPE TOWN, CENTER FOR INFECTIOUS DISEASE RESEARCH
Inventors:
Adam Garth PENN-NICHOLSON, Thomas Jens SCRIBA, Alan Arnold ADEREM, Daniel Edward ZAK, Ethan Greene THOMPSON, Willem Albert HANEKOM
Abstract: Practical assays to identify compounds that overcome the resistance of M. tuberculosis to bedaquiline are based on transcription factors Rv0324 and Rv0880 shown to mediate this resistance.
Type:
Application
Filed:
January 6, 2017
Publication date:
January 31, 2019
Applicants:
Institute for Systems Biology, Center for Infectious Disease Research
Abstract: The present application relates generally to biomarkers for tuberculosis (TB) infection and disease and methods of detection thereof. In various embodiments, the invention relates to one or more biomarkers, biomarker panels, methods, devices, reagents, systems, and kits for detecting and/or characterizing TB infection and/or disease.
Type:
Application
Filed:
May 7, 2016
Publication date:
December 13, 2018
Applicants:
SOMALOGIC, INC., UNIVERSITY OF CAPE TOWN, SEATTLE BIOMEDICAL RESEARCH INSTITUTE D/B/A THE CENTER FOR INFECTIOUS DISEASE RESEARCH
Inventors:
Thomas HRAHA, David STERLING, Urs A. OCHSNER, Nebojsa JANJIC, Thomas Jens SCRIBA, Adam Garth PENN-NICHOLSON, Willem Albert HANEKOM, Daniel Edward ZAK, Ethan Greene THOMPSON