Patents Assigned to Center for Neurologic Study
  • Analogs of dextromethorphan with balanced receptor activities
    Patent number: 11535596
    Abstract: Substituted analogs of dextromethorphan (DM) are disclosed, which are shown to have substantial binding affinity at both NMDA and sigma-1 receptors, and which are degraded by human liver enzymes more slowly than dextromethorphan. The analogs are useful as alternatives to dextromethorphan, and can provide the same benefits without requiring co-administration of a cytochrome P-450 enzyme inhibitor.
    Type: Grant
    Filed: August 30, 2021
    Date of Patent: December 27, 2022
    Assignee: Center for Neurologic Study
    Inventors: Richard Alan Smith, Darryl C. Rideout, Kathleen J. Myers, Andrew Kawasaki
  • Analogs of Dextromethorphan with Balanced Receptor Activities
    Publication number: 20220064122
    Abstract: Substituted analogs of dextromethorphan (DM) are disclosed, which are shown to have substantial binding affinity at both NMDA and sigma-1 receptors, and which are degraded by human liver enzymes more slowly than dextromethorphan. The analogs are useful as alternatives to dextromethorphan, and can provide the same benefits without requiring co-administration of a cytochrome P-450 enzyme inhibitor.
    Type: Application
    Filed: August 30, 2021
    Publication date: March 3, 2022
    Applicant: The Center for Neurologic Study
    Inventors: Richard Alan Smith, Darryl C. Rideout, Kathleen J. Meyers, Andrew Kawasaki
  • Dextromethorphan and an oxidase inhibitor for treating intractable conditions
    Patent number: 5863927
    Abstract: Methods are disclosed for increasing the effectiveness of dextromethorphan in treating chronic or intractable pain, for treating tinnitus and for treating sexual dysfunction comprising administering dextromethorphan in combination with a therapeutically effective dosage of a debrisoquin hydroxylase inhibitor. A preferred combination is dextromethorphan and the oxidative inhibitor quinidine.
    Type: Grant
    Filed: September 19, 1996
    Date of Patent: January 26, 1999
    Assignee: Center for Neurologic Study
    Inventors: Richard Alan Smith, Jonathan M. Licht
  • Dextromethorphan and an oxidase inhibitor for treating intractable conditions
    Patent number: RE38115
    Abstract: Methods are disclosed for increasing the effectiveness of dextromethorphan in treating chronic or intractable pain, for treating tinnitus and for treating sexual dysfunction comprising administering dextromethorphan in combination with a therapeutically effective dosage of a debrisoquin hydroxylase inhibitor. A preferred combination is dextromethorphan and the oxidative inhibitor quinidine.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: May 6, 2003
    Assignee: Center for Neurologic Study
    Inventors: Richard Alan Smith, Jonathan M. Licht