Patents Assigned to Centocor, Incorporated
  • Mass transfer membrane for oxygenation of animal cell reactors
    Patent number: 5288631
    Abstract: A tubular membrane suitable for the delivery of a gaseous fluid to a surrounding medium has an irregular exterior surface to facilitate the diffusion of gas from the lumen to the exterior.
    Type: Grant
    Filed: January 17, 1992
    Date of Patent: February 22, 1994
    Assignee: Centocor Incorporated
    Inventors: Mark F. Baumgartner, William R. Tolbert, John Shanahan
  • Method to enhance TPA production
    Patent number: 5210037
    Abstract: A medium supplement which promotes the secretion of tPA from cells producing this protein natively or by virtue of recombinant transformation without the concomitant addition of contaminating proteins is described. Autoclaved brain/heart infusion preparations contribute virtually no extraneous proteins to the medium but greatly enhance the secretion of tPA.
    Type: Grant
    Filed: February 2, 1990
    Date of Patent: May 11, 1993
    Assignee: Centocor Incorporated
    Inventors: Randall G. Rupp, John C. Lane
  • Method for labeling antibodies with a metal ion
    Patent number: 5177192
    Abstract: Methods for rapidly labeling sulfhydryl-containing antibodies or fragments with technetium or rhenium radioisotopes are disclosed. The method generally involves combining an aqueous mixture of the radiometal in an oxidized form, a reducing agent and a water-soluble polyhydroxycarbonylic acid ligand to form a stable complex of the radiometal in its reduced state and contacting the mixture with the sulfhydryl-containing antibody or fragment to produce a radiometal-labeled antibody or fragment.
    Type: Grant
    Filed: October 19, 1990
    Date of Patent: January 5, 1993
    Assignee: Centocor, Incorporated
    Inventors: Koon Y. Pak, Richard T. Dean, Jeffrey A. Mattis
  • Efficient large-scale purification of immunoglobulins and derivatives
    Patent number: 5118796
    Abstract: Improved methods for direct purification of product immunoglobulins or their derivatives from large volumes of mammalian cell culture medium include directly subjecting the cell culture medium to cation exchange treatment, so as to adsorb the product but not the contaminants. The eluted product is then recycled, or is applied to anion exchange, for further purification, and optionally subjected to additional steps. The product may be obtained in a form suitable for clinical applications, if desired.
    Type: Grant
    Filed: December 9, 1987
    Date of Patent: June 2, 1992
    Assignee: Centocor, Incorporated
    Inventors: Christopher P. Prior, Stephen A. Duffy, Billy J. Moellering
  • Mass transfer membrane for oxygenation of animal cell reactors
    Patent number: 5112760
    Abstract: Disclosed is a method of using a tubular membrane to deliver a gaseous fluid to a surrounding cell culture medium. The tubular membrane has an irregular exterior surface to facilitate the diffusion of gas from the lumen to the exterior.
    Type: Grant
    Filed: June 5, 1990
    Date of Patent: May 12, 1992
    Assignee: Centocor, Incorporated
    Inventors: Mark F. Baumgartner, William R. Tolbert, John Shanahan