Patents Assigned to Centocor Ortho Biotech Inc.
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Publication number: 20110281355Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells expressing markers characteristic of the pancreatic endoderm lineage, wherein greater than 50% of the cells in the population co-express PDX1 and NKX6.1.Type: ApplicationFiled: May 11, 2011Publication date: November 17, 2011Applicant: CENTOCOR ORTHO BIOTECH INC.Inventor: JEAN XU
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Patent number: 8017325Abstract: The invention describes a method for screening antibody producing cell lines for selection of high expressing clones.Type: GrantFiled: January 28, 2008Date of Patent: September 13, 2011Assignee: Centocor Ortho Biotech Inc.Inventor: Haimanti Dorai
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Publication number: 20110212067Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention provides methods of characterization of cells differentiated into cells expressing markers characteristic of the pancreatic endocrine lineage utilizing unique surface markers. The present invention also provides methods to enrich or sort cells expressing markers characteristic of the pancreatic endocrine lineage. The present invention also provides methods to deplete cells that may contaminate populations of cells expressing markers characteristic of the pancreatic endocrine lineage formed by the methods of the present invention, thereby reducing the incidence of tumor formation in vivo following transplantation.Type: ApplicationFiled: February 28, 2011Publication date: September 1, 2011Applicant: CENTOCOR ORTHO BIOTECH INC.Inventors: Francis Karanu, Alireza Rezania
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Patent number: 7943310Abstract: A method for prognostic or diagnostic assessment of a gastrointestinal-related disorder, such as ulcerative colitis, in a subject correlates the presence, absence, and/or magnitude of a gene in a sample with a reference standard to determine the presence and/or severity of the disorder, and/or the response to treatment for the disorder. The method enables identification of the effectiveness of candidate therapies.Type: GrantFiled: August 30, 2007Date of Patent: May 17, 2011Assignee: Centocor Ortho Biotech Inc.Inventors: Xilin Li, Xiao-yu Song
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Patent number: 7939322Abstract: The present invention is directed to pluripotent cells that can be readily expanded in culture on tissue culture substrate that is not pre-treated with protein or an extracellular matrix, and do not require a feeder cell line. The present invention also provides methods to derive the pluripotent cell line from human embryonic stem cells.Type: GrantFiled: April 24, 2008Date of Patent: May 10, 2011Assignee: Centocor Ortho Biotech Inc.Inventor: Alireza Rezania
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Publication number: 20110104805Abstract: The present invention provides methods to produce pluripotent stem cells from adult cells. In particular, the present invention provides methods to produce pluripotent stem cells from somatic cells without the use of a feeder-cell layer or an agent that increases efficiency of retroviral transfection.Type: ApplicationFiled: October 28, 2010Publication date: May 5, 2011Applicant: CENTOCOR ORTHO BIOTECH INC.Inventors: Ramie Fung, Benjamin Fryer
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Patent number: 7935344Abstract: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.Type: GrantFiled: December 28, 2006Date of Patent: May 3, 2011Assignee: Centocor Ortho Biotech Inc.Inventors: Jacqueline Benson, Jill Carton, Mark Cunningham, Yevgeniya I. Orlovsky, Robert Rauchenberger, Raymond Sweet
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Patent number: 7931905Abstract: Isolated polynucleotides encoding cynomolgus monkey gp80, polypeptides obtainable from expression of these polynucleotides, compositions, recombinant cells, methods of making and using these polynucleotides, polypeptides, and compositions are useful in development of human therapeutics.Type: GrantFiled: May 21, 2009Date of Patent: April 26, 2011Assignee: Centocor Ortho Biotech Inc.Inventors: Michael Naso, Ronald Swanson, Bethany Swencki-Underwood
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Patent number: 7887807Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders.Type: GrantFiled: July 9, 2009Date of Patent: February 15, 2011Assignee: Centocor Ortho Biotech Inc.Inventors: Jill Giles-Komar, David M. Knight, David Peritt, Bernard Scallon, David Shealy
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Patent number: 7879978Abstract: Isolated polynucleotides encoding Macaca fascicularis ST2L (Cyno ST2L), polypeptides obtainable from expression of these polynucleotides, recombinant cells, and methods of use are disclosed.Type: GrantFiled: March 31, 2009Date of Patent: February 1, 2011Assignee: Centocor Ortho Biotech, Inc.Inventors: Adam Cotty, Natalie Fursov, Michael Naso
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Patent number: 7807471Abstract: An anti-IL-23 specific human Ig derived protein, isolated nucleic acids that encode at least one anti-IL-23 Ig derived protein, vectors, host cells, transgenic animals or plants, and methods of making and using thereof are useful as therapeutic and diagnostic compositions, methods and devices. The anti-IL-23 Ig derived protein preferably binds to one or more of the Seg 1, Seg 2, and Seg 3 epitopes of the p40 subunit of IL-23.Type: GrantFiled: June 26, 2007Date of Patent: October 5, 2010Assignee: Centocor Ortho Biotech, Inc.Inventors: Jacqueline Benson, Mark Cunningham, Jeffrey (Sinquan) Luo
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Patent number: 7807414Abstract: An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.Type: GrantFiled: February 13, 2009Date of Patent: October 5, 2010Assignee: Centocor Ortho Biotech Inc.Inventors: Jacqueline Benson, Mark Cunningham, Cynthia Duchala, Jill M. Giles-Komar, Jinquan Luo, Michael A. Rycyzyn, Sweet Raymond
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Patent number: 7754207Abstract: Methods for treating pathological pulmonary conditions and bleomycin associated pulmonary fibrosis administer IL-16 antagonists, for example, anti-IL-16 antibodies, to subjects.Type: GrantFiled: October 26, 2007Date of Patent: July 13, 2010Assignee: Centocor Ortho Biotech Inc.Inventors: William Glass, Lynne Murray
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Publication number: 20100129318Abstract: The present invention relates to at least one novel cynomolgus IL-13 muteins (Mut-IL-13) proteins, antibodies, including isolated nucleic acids that encode at least one Mut-IL-13 protein or antibody, Mut-IL-13 vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.Type: ApplicationFiled: October 12, 2007Publication date: May 27, 2010Applicant: CENTOCOR ORTHO BIOTECH INC.Inventors: Karyn O'Neil, Leslee Conrad, Dusti Fisher
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Patent number: 7560247Abstract: Isolated nucleic acids encoding an anti-IL-12 antibody or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders.Type: GrantFiled: January 29, 2007Date of Patent: July 14, 2009Assignee: Centocor Ortho Biotech Inc.Inventors: Jill Giles-Komar, David M. Knight, David Peritt, Bernard Scallon, David Shealy
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Patent number: 7560112Abstract: An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.Type: GrantFiled: April 28, 2006Date of Patent: July 14, 2009Assignees: Applied Molecular Evolution, Inc., Centocor Ortho Biotech Inc.Inventors: Yan Chen, Debra Gardner, David M. Knight, Michael W. Lark, Bailin Liang, David J. Shealy, Xiao-Yu R. Song, Vedrana Stojanovic-Susulic, Raymond W. Sweet, Susan H. Tam, Sheng-Jiun Wu, Jing Yang, David Matthew Marquis, Eric Michael Smith, Alain Philippe Vasserot
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Patent number: 7547767Abstract: The present invention provides novel proteins and peptides from the receptor binding region of human Growth Arrest Specific Gene 6 (Gas6) and antibodies, including specified portions or variants, specific for at least one such Gas6 peptide or fragment thereof. The aforesaid peptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-Gas6 antibodies. The invention also provides for the nucleic acids encoding such peptides and anti-Gas6 antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, including therapeutic formulations, administration and devices. Fifteen novel peptide sequences from the Gas6 G domain that are implicated in Gas6 interactions with its receptors are identified, isolated, and synthesized so as to allow generation of anti-Gas6 antibodies. The peptide sequences include three ESTs that encompass regions predicted to contribute to receptor binding or that can raise anti-Gas6 antibodies.Type: GrantFiled: November 21, 2006Date of Patent: June 16, 2009Assignee: Centocor Ortho Biotech Inc.Inventors: Jing Yang, George Heavner, Robert Jordan, Jill Giles-Komar, Ray Sweet