Patents Assigned to Central Adelaide Local Health Network Inc.
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Publication number: 20240076393Abstract: A method of reducing IL-4 and/or IL-13 levels in the lung of a mammal with elevated levels thereof, includes the step of administering to the mammal an effective amount of a ?c receptor blocker capable of blocking the binding of all three of IL-3, IL-5 and GM-CSF to the ?c common chain to thereby reduce the IL-4 and/or IL-13 levels.Type: ApplicationFiled: August 14, 2023Publication date: March 7, 2024Applicants: CENTRAL ADELAIDE LOCAL HEALTH NETWORK INC., NEWCASTLE INNOVATION LTD.Inventors: Angel LOPEZ, Paul FOSTER
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Publication number: 20210317218Abstract: A method of reducing IL-4 and/or IL-13 levels in the lung of a mammal with elevated levels thereof, includes the step of administering to the mammal an effective amount of a ?c receptor blocker capable of blocking the binding of all three of IL-3, IL-5 and GM-CSF to the ?c common chain to thereby reduce the IL-4 and/or IL-13 levels.Type: ApplicationFiled: January 15, 2021Publication date: October 14, 2021Applicants: CENTRAL ADELAIDE LOCAL HEALTH NETWORK INC., NEWCASTLE INNOVATION LTD.Inventors: Angel LOPEZ, Paul FOSTER
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Publication number: 20200079858Abstract: The present description relates to a conjugated anti-interleukin-5 receptor ?-subunit (IL-5R?) compound comprising cholic acid (ChAc) or a variant thereof, the ChAc conjugated to a non-cell penetrating peptide comprising a nuclear localization sequence (NLS) conjugated to an anti-interleukin-5 receptor ?-subunit (IL-5R?) compound and further conjugated to chemotherapeutic agent and/or a radionuclide.Type: ApplicationFiled: March 14, 2018Publication date: March 12, 2020Applicants: UNIVERSITY OF SOUTH AUSTRALIA, CENTRAL ADELAIDE LOCAL HEALTH NETWORK INC.Inventors: Jeffrey Victor LEYTON, Eric MARSAULT, Simon BEAUDOIN, Pierre-Luc BOUDREAULT, Marc-André BONIN, Angel LOPEZ
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Patent number: 10583115Abstract: The present disclosure relates to modulators of 14-3-3 functionality and their use in methods and compositions for preventing and/or treating various diseases, conditions and states, such as cancer and healing of wounds. Certain embodiments of the present disclosure provide a method of preventing and/or treating a disease, condition or state in a subject associated with altered 14-3-3 protein functionality and/or which would benefit from altering 14-3-3 functionality, the method comprising administering to the subject an effective amount of an agent which inhibits dimerization of the 14-3-3 protein, thereby preventing and/or treating the disease, condition or state in the subject.Type: GrantFiled: October 8, 2015Date of Patent: March 10, 2020Assignees: University of South Australia, Central Adelaide Local Health Network Inc.Inventors: Joanna Woodcock, Angel Lopez, Stuart Maxwell Pitson, Michael Susithiran Samuel, Carl Coolen
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Publication number: 20200055943Abstract: A method of reducing IL-4 and/or IL-13 levels in the lung of a mammal with elevated levels thereof, includes the step of administering to the mammal an effective amount of a ?c receptor blocker capable of blocking the binding of all three of IL-3, IL-5 and GM-CSF to the ?c common chain to thereby reduce the IL-4 and/or IL-13 levels.Type: ApplicationFiled: March 22, 2019Publication date: February 20, 2020Applicants: CENTRAL ADELAIDE LOCAL HEALTH NETWORK INC., NEWCASTLE INNOVATION LTD.Inventors: Angel LOPEZ, Paul FOSTER
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Patent number: 9873723Abstract: Methods and kits for the diagnosis of illnesses related to protocadherin 19 (PCDH 19) protein deficiency or altered PCDH 19 protein function, in particular EFMR (Epilepsy and Mental Retardation limited to Females) are provided, as well as methods and kits for the identification of a predisposition to such illnesses and methods of screening subjects to identify carriers of such illnesses and methods and kits for the therapeutic or prophylactic treatment of PCDH 19 deficiency or altered PCDH 19 protein function. Further, nucleotide and amino acid sequences corresponding to a complete PCDH19 open reading frame (ORF), mutant sequences encoding non-functional PCDH19 mRNA or altered PCDH19 mRN A are described along with transformed cells and non-human transgenic animals comprising wild-type or mutant PCDH19 ORF nucleotide sequences.Type: GrantFiled: January 5, 2009Date of Patent: January 23, 2018Assignees: The University of Melbourne, Central Adelaide Local Health Network Inc.Inventors: Leanne Michelle Dibbens, Ingrid Eileen Scheffer, Samuel Frank Berkovic, John Charles Mulley, Jozef Gecz
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Publication number: 20170312249Abstract: The present disclosure relates to modulators of 14-3-3 functionality and their use in methods and compositions for preventing and/or treating various diseases, conditions and states, such as cancer and healing of wounds. Certain embodiments of the present disclosure provide a method of preventing and/or treating a disease, condition or state in a subject associated with altered 14-3-3 protein functionality and/or which would benefit from altering 14-3-3 functionality, the method comprising administering to the subject an effective amount of an agent which inhibits dimerization of the 14-3-3 protein, thereby preventing and/or treating the disease, condition or state in the subject.Type: ApplicationFiled: October 8, 2015Publication date: November 2, 2017Applicants: University of South Australia, Central Adelaide Local Health Network Inc.Inventors: Joanna Woodcock, Angel Lopez, Stuart Maxwell Pitson, Michael Susithiran Samuel, Carl Coolen
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Publication number: 20160361362Abstract: The present disclosure provides methods of improving cerebral function or preventing loss of cerebral function and/or treating or preventing a movement disorder and/or regenerating cerebral neurons in a subject who has suffered a stroke, the method comprising administering to the subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.Type: ApplicationFiled: August 11, 2014Publication date: December 15, 2016Applicants: CENTRAL ADELAIDE LOCAL HEALTH NETWORK INC, MESOBLAST, INC.Inventors: Simon Andrea KOBLAR, Stan GRONTHOS, Agnieszka ARTHUR
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Publication number: 20140065241Abstract: A method for treating or preventing a disease, condition or state in a subject in need thereof by administering to the subject an effective amount of the (?)-enantiomer of perhexyline or a pharmaceutically acceptable salt, prodrug or derivative thereof, substantially free of the (+)-enantiomer, or pharmaceutical composition containing same. The disease, condition or state may be associated with altered tissue energetics, impaired tissue energetics, altered cardiac tissue energetics, impaired cardiac tissue energetics, altered hepatic tissue energetics, impaired hepatic tissue energetics, and diabetes.Type: ApplicationFiled: September 5, 2013Publication date: March 6, 2014Applicants: Adelaide Research & Innovation Pty Ltd, ITEK Ventures Pty Ltd, Central Adelaide Local Health Network Inc.Inventors: Benedetta SALLUSTIO, Robert MILNE, John LICARI, Andrew Alexander SOMOGYI