Abstract: Methods of treatment and prevention of diseases associated with release of neutrophil elastase and IL-8 by administration of TFPI, and analogs of TFPI are disclosed. Methods of determining efficacy of treatment with TFPI, patient's responsiveness to treatment with TFPI and the ultimate determination of patient prognosis are also disclosed.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
June 5, 2001
Assignees:
Chiron Corporation, Central Laboratory of The Netherlands Red Cross Blood
Tranfusion Service
Inventors:
Kirk Johnson, Abla A. Creasey, Lucien A. Aarden