Abstract: Described herein are trehalose analogues. Also described herein are methods of making the trehalose analogues and uses of the analogues. For example, the disclosed trehalose analogues may be useful in the detection of bacteria.

Abstract: Aspects of the disclosure relate to nanoparticle formulations and methods for generating nanoparticles. Embodiments include nanoparticles comprising an amphiphile and a polymer co-assembly agent. In some cases, polymers for use in therapeutic delivery are described. In some embodiments, the disclosed methods and compositions involve TLR agonists and formulations thereof capable of activating an immune response. Certain aspects relate to nanoparticles comprising linked TLR agonists for use in immunotherapy.

Abstract: Described herein are trehalose analogues. Also described herein are methods of making the trehalose analogues and uses of the analogues. For example, the disclosed trehalose analogues may be useful in the detection of bacteria.

Abstract: The present invention provides a method of bioluminescence-driven optogenetic control of excitable cells. The excitable cell expresses a light-gated ion channel, and a luminescent protein can be expressed either in the excitable cell or in another cell proximal to the excitable cell. The methods of the invention can be used to desynchronize local activity of excitable cells in a mammalian tissue. The methods of the invention can be used to treat a disease or condition in a mammal, the disease or condition being related to bursting. The disease or condition can be Parkinson's disease, epilepsy, a sleep disorder, or a sensory-related disease or condition (e.g., attention deficit disorder or pain). The invention also provides a conjugate of containing a voltage-gated ion channel and a luminescent protein.

Abstract: Artificial intervertebral discs include an annulus fibrosus portion and a nucleus pulposus portion. Annulus fibrosus portions disclosed and contemplated herein include a plurality of layers. Fibers within the layers are arranged to provide a crisscross pattern between adjacent layers. Nucleus pulposus portions disclosed and contemplated herein can include a flexible, sealed enclosure.

Abstract: Described herein are trehalose analogues. Also described herein are methods of making the trehalose analogues and uses of the analogues. For example, the disclosed trehalose analogues may be useful in the detection of bacteria.

Abstract: The present invention provides methods of synthesizing trehalose analogues; methods of detecting mycobacteria, and trehalose analogues.

Abstract: Described herein are trehalose analogues. Also described herein are methods of making the trehalose analogues and uses of the analogues. For example, the disclosed trehalose analogues may be useful in the detection of bacteria.

Abstract: An asymmetric Stockbridge damper having at least six and as many as ten resonant frequencies. The damper includes two assemblies, each having a primary weight at the end of a messenger cable and two secondary weights at the ends of thin beams. The thin beams are mounted at one end to the primary weight and each support a secondary weight at an opposite end. The thin beams extend parallel to the messenger cable. The messenger cable is affixed to a clamp assembly which clamps to an overhead transmission line. The clamp assembly includes a toggle crank generating a theoretically infinite clamping force on the transmission line.

Abstract: An environmental friendly, continuous biomass torrefaction system is disclosed herein. This torrefaction system captures carbon dioxide (CO2) from the combustion gases generated in the process. A portion of the captured CO2 is recycled and used as the inert gas for torrefying biomass and cooling the torrefied biomass. The rest of the captured CO2 is stored.

Abstract: An asymmetric Stockbridge damper having at least six and as many as ten resonant frequencies. The damper includes two assemblies, each having a primary weight at the end of a messenger cable and two secondary weights at the ends of thin beams. The thin beams are mounted at one end to the primary weight and each support a secondary weight at an opposite end. The thin beams extend parallel to the messenger cable. The messenger cable is affixed to a clamp assembly which clamps to an overhead transmission line. The clamp assembly includes a toggle crank generating a theoretically infinite clamping force on the transmission line.

Abstract: The present invention provides methods of synthesizing trehalose analogs; methods of detecting mycobacteria, and trehalose analogs.

Abstract: A method and apparatus for determining an inattentive state of an operator of a vehicle and for providing information to the operator of the vehicle by obtaining face images of the operator of the vehicle, obtaining images of an environment of the vehicle, determining one or more areas of interest in the environment of the vehicle based on the images of the environment, obtaining, from a relevance and priority database, relevance and priority values corresponding to the one or more areas of interest, determining a probability of attention of the operator of the vehicle to the one or more areas of interest based on the images of the environment and the relevance and priority values, determining an attention deficiency based on the determined probability of attention and the face images, and providing the information to the operator of the vehicle based on the determined attention deficiency.

Abstract: Among other things the invention provides novel flame-retardant compounds useful for increasing the flame retardance of polymers.

Abstract: A method and apparatus for determining an inattentive state of an operator of a vehicle and for providing information to the operator of the vehicle by obtaining face images of the operator of the vehicle, obtaining images of an environment of the vehicle, determining one or more areas of interest in the environment of the vehicle based on the images of the environment, obtaining, from a relevance and priority database, relevance and priority values corresponding to the one or more areas of interest, determining a probability of attention of the operator of the vehicle to the one or more areas of interest based on the images of the environment and the relevance and priority values, determining an attention deficiency based on the determined probability of attention and the face images, and providing the information to the operator of the vehicle based on the determined attention deficiency.

Abstract: A method and apparatus for determining an inattentive state of an operator of a vehicle and for providing information to the operator of the vehicle by obtaining face images of the operator of the vehicle, obtaining images of an environment of the vehicle, determining one or more areas of interest in the environment of the vehicle based on the images of the environment, obtaining, from a relevance and priority database, relevance and priority values corresponding to the one or more areas of interest, determining a probability of attention of the operator of the vehicle to the one or more areas of interest based on the images of the environment and the relevance and priority values, determining an attention deficiency based on the determined probability of attention and the face images, and providing the information to the operator of the vehicle based on the determined attention deficiency.

Abstract: One embodiment provides a method, comprising: calculating, using at least one computer, a distance to a hull for an alloy XxY1-x in the range 0.01?x?0.99, where X and Y are perovskite materials; determining, using the at least one computer, a preferred phase for the alloy in the range 0.01?x?0.99; and selecting an alloy composition having the distance to the hull being less than 0.1 eV/atom and for which the preferred phase in at least a portion of the range 0.01?x?0.99 is a tetragonal phase. Piezoelectric materials as selected by the method are also provided.

Abstract: Provided are dendritic nano-antioxidant compounds according to Formula I, which may further comprise active agents covalently or non-covalently attached. Further provided are compositions comprising the disclosed compounds. Also disclosed are cosmetic compositions and dietary supplements comprising the compounds according to Formula I. The invention additionally provides methods of reducing free radicals or oxidative stress in a cell, a method of treating a subject, and a method of treating a condition comprising administering the compounds according to Formula I.

Abstract: A method for using a polymer-carbon sorbent for removing one or more of carbon dioxide, heavy metals or toxic materials from a flue gas from coal-fired power plants is described. The sorbent comprises a carbonaceous sorbent material and a cured amine-containing polymer, and sulfur. The polymer-carbon sorbents are formed by curing a curable amine-containing polymer in the presence of the carbonaceous sorbent material, sulfur, a cure accelerator and, optionally, a cure activator. A convenient carbonaceous sorbent material is an activated carbon, and a convenient curable amine-containing polymer is an allyl-containing poly(ethyleneimine), having a number average molecular weight between about 1,000 and about 10,000. The polymer-carbon sorbents may contain sulfur in molar excess of an amount needed to cure the curable amine-containing polymer. Such polymer-carbon sorbents are shown to capture more mercury, in both elemental an ionic forms, compared to activated carbon and adsorb carbon dioxide.

Abstract: A polymer-carbon sorbent for removing at least one of carbon dioxide, heavy metals or toxic materials from a flue gas from a combustion process, such as coal-fired power plants, is described. The sorbent comprises a carbonaceous sorbent material and a cured amine-containing polymer, and sulfur. The polymer-carbon sorbents are formed by curing a curable amine-containing polymer in the presence of the carbonaceous sorbent material, sulfur, a cure accelerator and, optionally, a cure activator. A convenient carbonaceous sorbent material is an activated carbon, and a convenient curable amine-containing polymer is an allyl-containing poly(ethyleneimine), having a number average molecular weight between about 1,000 and about 10,000. The polymer-carbon sorbents may contain sulfur in molar excess of an amount needed to cure the curable amine-containing polymer. Such polymer-carbon sorbents are shown to capture more mercury, in both elemental an ionic forms, compared to activated carbon and adsorb carbon dioxide.