Abstract: This invention relates to a process for the treatment of patients suffering from drepanocytosis, comprising administering to said patients a therapeutically effective dosage of a pyridine derivative having the formula: ##STR1## in which X is oxygen or sulfur; R is oxygen or a phenyl radical optionally substituted with at least a halogen atom or a lower alkyl, lower alkoxy, nitro, amino, sufonylamino, aryl, carboxy, alkoxycarbonyl, cyano, hydroxymethyl or methylenedioxy group; a styryl, naphthyl, thienyl or benzhydryl radical optionally substituted with at least a halogen atom or a lower alkyl, lower alkoxy, aryl, nitro, amino, sulfonylamino, carboxy, alkoxycarbonyl, cyano, hydroxymethyl or methylenedioxy group; or a benzoyl radical optionally substituted with at least a halogen atom or a lower alkyl, lower alkoxy, nitro, amino or sulfonylamino group; R.sub.1 and R.sub.2 represent each at least an atom or group selected from hydrogen, halogen, or a hydroxy, lower alkyl, lower alkoxy, nitro or amino group; R.

Abstract: The present invention relates to pyridine derivatives having the formula: ##STR1## in which: R is a radical selected from a phenyl radical mono- and polysubstituted with a group selected from the aryl, carboxy, alkoxycarbonyl, cyano, hydroxymethyl and ethylenedioxy groups; a styryl, thienyl and benzhydryl radical optionally mono- and polysubstituted with a group selected from halogen, lower alkyl, lower alkoxy, aryl, nitro, amino, sulfonylamino, carboxy, alkoxycarbonyl, cyano, hydroxymethyl and methylenedioxy;R.sub.1 and R.sub.2 represent each a group selected from hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, nitro and amino;R.sub.3 represents a group selected from hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, nitro and amino; andn is an integer from 1 to 15,And in which the symbols R.sub.3 may have different meanings in each radical CHR.sub.

Abstract: This invention relates to a therapeutic composition comprising, as active ingredient, a combination of 5-(2-chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine and acetylsalicylic acid, the components of the combination being both present in the free state or as a pharmacologically acceptable salt. Said composition is useful both preventively and curatively for the treatment of thrombo-embolic diseases.

Abstract: Pyridinium derivatives having the formula: ##STR1## in which X is O or S; R is benzoyl optionally substituted with at least halogen or lower alkyl, lower alkoxy, hydroxy or nitro; R.sub.1 is hydrogen, halogen, hydroxy or lower alkyl, R.sub.2 is hydrogen or halogen and n is from 1 to 2, and in which R.sub.1 may be different in each CHR.sub.1 when n is 2.Said derivatives are therapeutically useful for their anti-arrhythmic activity.

Abstract: Thieno[3,2-c]pyridine derivatives having the formula: ##STR1## in which X is S; R is a phenyl or benzoyl radical optionally substituted with 1-3 halogen atoms or lower alkyl, lower alkoxy, hydroxy or nitro; R.sub.1 is hydrogen, halogen, hydroxy or lower alkyl; R.sub.2 is hydrogen or halogen and n is 1 or 2, and in which the symbols R.sub.1 may be different in each CHR.sub.1 when n is 2; and their pharmaceutically acceptable acid addition salts.Said derivatives are therapeutically useful for their anti-inflammatory, vasodilatator and blood plate aggregation inhibitor action.

Abstract: Hypocholesterolemic compounds of formula ##STR1## wherein R.sub.1 to R.sub.5, which may be the same or different, are hydrogen or halogen atoms or hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulphonylamino groups; or R.sub.1 and R.sub.2 together represent a methylenedioxy group, R.sub.6 is a hydrogen atom or a lower alkyl group; R.sub.7 is a lower alkyl, lower cycloalkyl, phenyl or lower phenylalkyl group; or wherein R.sub.6 and R.sub.7 when taken together with the nitrogen atom to which together with the nitrogen atom to which they are linked represent a saturated heterocyclic group having 5 to 7 ring members (optionally comprising an oxygen atom or another nitrogen atom as a second heteroatom, which latter nitrogen atom is unsubstituted or substituted by a lower alkyl group); and n is an integer of from 0 to 5; and the salts thereof.

Abstract: Amino-2 thiazoles of the formulae ##STR1## and ##STR2## wherein R.sub.1 and R.sub.2 are each selected from hydrogen, lower alkenyl radicals, lower alkyl radicals, lower cycloalkyl radicals, phenyl radical, lower cycloalkylphenyl radicals, lower phenylalkyl radicals, lower halogenoalkenyl radicals, lower halogenoalkyl radicals, lower halogenocycloalkyl radicals, halogenophenyl radicals, lower halogenoalkyl radicals, and the same radicals substituted by at least a hydroxy, R.sub.3 and R.sub.4 are each selected from hydrogen, lower alkyl and lower cycloalkyl, one at least of R.sub.1 and R.sub.2 being cyclic, and their salts, have valuable hypocholesterolemic activity.

Abstract: Hypocholesterolemic compounds of formula ##SPC1##WhereinR.sub.1 to R.sub.5, which may be the same or different, are hydrogen or halogen atoms or hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulphonylamino groups;OrR.sub.1 and R.sub.2 together represent a methylenedioxy group, R.sub.6 is a hydrogen atom or a lower alkyl group;R.sub.7 is a lower alkyl, lower cycloalkyl, phenyl or lower phenylalkyl group;Or whereinR.sub.6 and R.sub.7 when taken together with the nitrogen atom to which together with the nitrogen atom to which they are linked represent a saturated heterocyclic group having 5 to 7 ring members (optionally comprising an oxygen atom or another nitrogen atom as a second heteroatom, which latter nitrogen atom is unsubstituted or substituted by a lower alkyl group);AndN is an integer of from 0 to 5;And the salts thereof.