Patents Assigned to CENTRE DE RECHERCHE DES CORDELIERS
  • METHODS FOR TREATMENT OF BACTERIAL INFECTIONS
    Publication number: 20120115835
    Abstract: The peptidoglycan layer is a vital component of the bacterial cell wall, which comprises 4?3 and 3?3 transpeptide cross-linkages, the formation of which are catalyzed by D,D- and L,D-transpeptidases, respectively. Methods for the treatment of bacterial infections with agents that inhibit L,D-transpeptidases, either alone or in combination with D,D-transpeptidase inhibitors, are provided herein. Also provided are methods for the treatment of chronic stage tuberculosis with agents that inhibit enzyme with L,D-transpeptidase activity.
    Type: Application
    Filed: October 27, 2011
    Publication date: May 10, 2012
    Applicants: CENTRE DE RECHERCHE DES CORDELIERS, THE JOHNS HOPKINS UNIVERSITY
    Inventors: Gyanu Lamichhane, William R. Bishai, Radhika Gupta, Marie Lavollay, Jean-Luc Mainardi, Michel Arthur