Patents Assigned to Centre Europeen de Recherches Mauvernay
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Patent number: 4430332Abstract: The invention is dealing with compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof, in which R.sub.1 and R.sub.2 each represent a lower alkyl radical or a phenyl radical, or, together with the carbon atom to which they are bound, a cycloalkyl radical having at the most 7 carbon atoms; R.sub.3 represents hydrogen, a lower alkyl radical, or the phenyl radical; R.sub.4 and R.sub.5 each represent a lower alkyl radical, or, together with the nitrogen atom to which they are bound, a heterocyclic amino radical such as the pyrrolidinyl or morpholino radicals; and R.sub.6 represents a lower alkyl radical, a phenyl radical, a benzyl radical, or the 1-ethynyl-cyclohexyl radical, which compounds can be used in the treatment of angina pectoris.Type: GrantFiled: December 19, 1980Date of Patent: February 7, 1984Assignee: Centre Europeen de Recherches MauvernayInventors: Patrick Carlier, Andre J. C. Monteil, Jacques A. L. Simond
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Patent number: 4218473Abstract: The present invention relates to derivatives of 4-cyclohexyl-1-naphthalene-acetic acid of formula ##STR1## wherein R is a lower alkyl group and pharmaceutically acceptable salts and derivatives thereof the invention also relates to pharmaceutic compositions containing such derivatives.These derivatives are useful as drugs, notably for the treatment of inflammatory syndromes.Type: GrantFiled: September 26, 1978Date of Patent: August 19, 1980Assignee: Centre Europeen de Recherches MauvernayInventors: Jean-Jacques Godfroid, Efroim Steiner
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Patent number: 4105785Abstract: Substituted methyl-2-[(dimethylamino-3')propylidene]-4-dihydro-9,10-benzo-[4,5]cyclohe pta[1,2-b]-furan compounds are described which are useful in the treatment of depressive syndromes and which may be obtained by cyclization from substituted derivatives of furan.Type: GrantFiled: March 16, 1977Date of Patent: August 8, 1978Assignee: Centre Europeen de Recherches MauvernayInventors: Roland Y. Mauvernay, Norbert Busch, Jacques Moleyre
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Patent number: 4086216Abstract: A process for obtaining an anti-viral substance, useful in herpetiform diseases, from Psalliota Xanthoderma is described.Type: GrantFiled: December 2, 1975Date of Patent: April 25, 1978Assignee: Centre Europeen de Recherches Mauvernay "C.E.R.M."Inventors: Roland-Yves Mauvernay, Henri-Jean Pourrat, Jean-Louis Lamaison
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Patent number: 4086352Abstract: The invention relates to novel 6-aryloxy-2-oxo-1-aza-4-(or thia)-spiro[4,5]decane compounds. These compounds are represented by the formula: ##STR1## in which A stands for an oxygen or sulfur heteroatom; R.sub.1 and R.sub.2 are each H, lower alkyl or aryl such as phenyl; X is H, a halogen atom such as chlorine or fluorine or a lower alkyl.Compounds according to the invention are useful as stimulating agents for vigilance, as psycho-stimulators and genesic stimulators.Type: GrantFiled: August 25, 1970Date of Patent: April 25, 1978Assignee: Centre Europeen de Recherches MauvernayInventors: Roland Yves Mauvernay, Norbert Busch, Jacques Moleyre, Jacques Simond, Andre Monteil
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Patent number: 4062956Abstract: 2-(2-Hydroxyethyl)tetrahydro-1,4-oxazines and quaternary salts thereof having the formula: ##STR1## WHEREIN Ar and Ar.sub.1 are the same or different and are unsubstituted and substituted aryl, said substituent being a halogen atom, R represents a lower alkyl group having from 1 to 4 carbon atoms, R.sub.1 is zero when X.sup.(-) is zero or is an alkyl group of from 1 to 4 carbon atoms which is the same or different from R, as defined above, and X.sup.(-) is zero when R.sub.1 is zero or is selected from the group consisting of Cl.sup.(-), Br.sup.(-), I.sup.(-) and CH.sub.3 SO.sub.4.sup.(-) when R.sub.1 is lower alkyl, as defined above, is described. These compounds are useful for treating spasmodic syndromes.Type: GrantFiled: September 16, 1976Date of Patent: December 13, 1977Assignee: Centre Europeen de Recherches MauvernayInventors: Roland Yves Mauvernay, Norbert Busch, Jacques Moleyre, Jacques Simond, Andre Monteil
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Patent number: 4035498Abstract: Compounds of the formula: ##STR1## wherein R is a lower alkyl group, X is oxygen or the group --(CH.sub.2).sub.n -- where n is 0 or 1, having bronchospasmolytic activity, are described.Type: GrantFiled: September 29, 1975Date of Patent: July 12, 1977Assignee: Centre Europeen de Recherches MauvernayInventors: Roland Yves Mauvernay, Norbert Busch, Jacques Moleyre, Jacques Simond, Andre Monteil
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Patent number: 4033818Abstract: The invention provides a process for the preparation of a complete extract of pilewort roots, used in cosmetological compositions, which consists of first subjecting the dried and ground roots to an extraction with 35.degree.-45.degree. C petroleum ether and then treating the insoluble powder by extraction with an aqueous lower alcohol. After having removed the insoluble impurities by filtration, the filtrate is treated with papaine and is concentrated to a solids content of 40 to 50%. Aqueous alcohol is then added to the concentrated extract and the deposit thus formed is removed by decantation when cold, leaving the desired extract.Type: GrantFiled: July 15, 1976Date of Patent: July 5, 1977Assignee: Centre Europeen de Recherches Mauvernay C.E.R.M.Inventors: Henri Pourrat, Aimee Pourat nee Gaillard
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Patent number: 4011240Abstract: This invention relates to a new group of substituted cysteines having the general formula: ##STR1## in which: Ar is an aromatic or heteromonocyclic group, such as 2-thienyl or phenyl, which may be substituted by a halogen atom or by a lower alkyl or alkoxy group, and R is a hydrogen atom or a lower alkyl group.These compounds are of use in human therapeutics as liquifiers for bronchal secretions in complaints of the respiratory passage and, in particular, in chronic bronchitis.The invention also relates to a method of preparing these compounds and to the application of these compounds, particularly in human therapeutics.Type: GrantFiled: October 12, 1972Date of Patent: March 8, 1977Assignee: Centre Europeen de Recherches Mauvernay (CERM)Inventors: Roland-Yves Mauvernay, Andre Monteil, Jacques Simond, Jacques Moleyre, Norbert Busch
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Patent number: 3962238Abstract: Ethers of n-propanolamine, preparation thereof and their use in treatment of cardiovascular conditions.Type: GrantFiled: February 27, 1973Date of Patent: June 8, 1976Assignee: Centre Europeen de Recherches Mauvernay "CERM"Inventors: Roland Yves Mauvernay, Norbert Busch, Jacques Moleyre, Andre Monteil, Jacques Simond
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Patent number: 3936450Abstract: Tetra-substituted ethylenes having the general formula ##EQU1## in which R is selected from the group consisting of alkyl radicals containing 1 to 4 carbon atoms and ##SPC1## AND A is selected from the group consisting of ##EQU2## and salts thereof with pharmacologically acceptable acids are useful as anti-inflammatory agents.Type: GrantFiled: February 7, 1973Date of Patent: February 3, 1976Assignee: Centre Europeen de Recherches Mauvernay "C.E.R.M."Inventors: Roland Yves Mauvernay, Norbert Bush, Jacques Simond, Andre Monteil, Jacques Moleyre
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Patent number: RE29902Abstract: 6-Aryloxy-2-oxo-1-aza-4-oxa (or thia)-spiro[ 4,5]decane compounds. These compounds are represented by the formula ##STR1## in which A stands for an oxygen or sulfur heteroatom; R.sub.1 and R.sub.2 are each H, lower alkyl or aryl such as phenyl; X is H, a halogen atom such as chlorine or fluorine or a lower alkyl. Compounds according to the invention are useful as stimulating agents for vigilance, as psycho-stimulators and genesic stimulators.Type: GrantFiled: October 17, 1977Date of Patent: February 6, 1979Assignee: Centre Europeen de Recherches MauvernayInventors: Roland Y. Mauvernay, Norbert Busch, Jacques Moleyre, Jacques Simond, Andre Monteil
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Patent number: RE30577Abstract: .[.Ethers.]. .Iadd.An ether .Iaddend.of n-propanolamine, preparation thereof and .[.their.]. .Iadd.its .Iaddend.use in treatment of cardiovascular conditions.Type: GrantFiled: February 27, 1979Date of Patent: April 14, 1981Assignee: Centre Europeen de Recherches MauvernayInventors: Norbert Busch, Jacques Simond, Andre Monteil, Jacques Moleyre, Roland Y. Mauvernay