Abstract: The present invention relates to a novel method for the affinity purification of proteins of interest in a single step, based on the lectin activity of the CRD (Carbohydrate Recognition Domain) of a galectin or part of said domain retaining the ability to bind ?-galactosidase derivative.
Type:
Grant
Filed:
May 11, 2017
Date of Patent:
May 30, 2023
Assignees:
UNIVERSITÉ DE LORRAINE, CENTRE HOSPITALIER RÉGIONAL DE NANCY
Abstract: A method is provided for identifying an isthmus in a three-dimensional map of a cardiac cavity by means of a processing unit configured to perform the following steps: a) correlation between a set of stimulated points of the cardiac cavity, each stimulated point being represented by a set of signals that are obtained following surface electrocardiography (ECG), excluding ventricular tachycardia; b) identification of a watershed line on the basis of the above correlation results and of the 3D coordinates of the stimulated points in the 3D map; and c) determination of the isthmus based on a 3D corridor substantially transverse to the watershed line.
Type:
Grant
Filed:
April 1, 2016
Date of Patent:
January 12, 2021
Assignees:
UNIVERSITE DE LORRAINE, CENTRE HOSPITALIER REGIONAL DE NANCY
Abstract: A method is provided for determining a personalized cardiac model, including steps of (i) computing a velocity time profile of a blood flow across a selected area of the heart or the aorta during at least one cardiac cycle, using data acquired with a Magnetic Resonance Imaging (MRI) device; (ii) performing a segmentation of the velocity time profile so as to identify cardiac phases according to a predefined generic cardiac model; and (iii) computing normalized time location and/or duration of the cardiac phases within cardiac cycles so as to define a personalized cardiac model.
Type:
Grant
Filed:
January 7, 2014
Date of Patent:
February 4, 2020
Assignees:
UNIVERSITE DE LORRAINE, CENTRE HOSPITALIER REGIONAL DE NANCY
Inventors:
Christophe Meyer, Pierre-André Vuissoz, Laurent Bonnemains, Jacques Felblinger
Abstract: A method is provided of reconstructing imaging signals in a biological medium on the basis of experimental measurements perturbed by movements, implementing measurements representative of the movements, at least one model of movement including movement parameters, and an imaging sampling grid, which method furthermore includes steps of (i) constructing a movement sampling grid by selecting a restricted set of points on the basis of the imaging sampling grid, and (ii) calculation of movement parameters by inverting a linear system at the points of the movement sampling grid. Devices implementing the method are also disclosed.
Type:
Grant
Filed:
December 11, 2012
Date of Patent:
March 1, 2016
Assignees:
UNIVERSITE DE LORRAINE, CENTRE HOSPITALIER REGIONAL DE NANCY
Inventors:
Anne Menini, Jacques Felblinger, Freddy Odille, Pierre-Andre Vuissoz
Abstract: A method is provided of reconstructing imaging signals in a biological medium on the basis of experimental measurements perturbed by movements, implementing measurements representative of the movements, at least one model of movement including movement parameters, and an imaging sampling grid, which method furthermore includes steps of (i) constructing a movement sampling grid by selecting a restricted set of points on the basis of the imaging sampling grid, and (ii) calculation of movement parameters by inverting a linear system at the points of the movement sampling grid. Devices implementing the method are also disclosed.
Type:
Application
Filed:
December 11, 2012
Publication date:
December 4, 2014
Applicants:
CENTRE HOSPITALIER REGIONAL DE NANCY, UNIVERSITE DE LORRAINE
Inventors:
Anne Menini, Jacques Felblinger, Freddy Odille, Pierre-Andre Vuissoz