Abstract: The present invention relates to methods and kits for the prediction of risk for heart failure using post-translation modified forms of cardiac troponin T as a biomarker.

Abstract: Process for preserving insulin secreting cells intended to be transplanted, including the following steps: introducing an initial volume of culture medium and insulin-secreting cells into a culture container, providing a culture medium source, and replacing, at time intervals below 8 hours, the culture medium in the culture container with culture medium from the source so as to renew the culture medium contained in the container.

Abstract: The present invention relates to methods and kits for predicting the risk of respiratory failure, renal failure or thrombopenia in a septic patient. More particularly, the present invention relates to a method for predicting the risk of having an organ failure selected from the group consisting of respiratory failure, renal failure and thrombopenia in a septic patient comprising a step consisting of measuring the concentration of endocan in a blood sample obtained from said septic patient.

Abstract: The inventive method for processing an RR series comprises a plurality of (RR) samples representing time intervals (dti) between two successive heart beats or the inverse (1/dti) of said time intervals consists in selecting (N) (RRi) samples in a main time window having a predetermined length (n), in cutting said main window into (m) subwindows (Fj), in calculating an intermediate parameter (A1) for each subwindow (Fj) on the basis of the (RRi) samples contained in the subwindow (Fj) and in calculating a final parameter as a function of the intermediate parameters (Aj). The invention is used for analysing a cardiac rhythm variability, in particular for assessing a patient's pain or stress.

Abstract: The present invention relates to 1,4-dihydropyridine derivatives of the formula (I) and their uses in the treatment and/or prevention of diseases and disorders directly or indirectly associated with the modification (increase or decrease) of the activity of the cannabinoid receptor 2 (CB2).

Abstract: A method for preserving a preparation of insulin-secreting cells includes the step of placing the preparation of insulin-secreting cells in contact with a biological medium, the biological medium including a nutritive product including albumin, and further includes a peptone or a mixture of peptones in sufficient quantity to preserve the insulin-secreting cells.

Abstract: The RR series, comprising a number of samples respectively defining the time interval between two successive heartbeats, is filtered by means of a digital band-pass filter (Fk), having a given band-pass [fc; f?c] and preferably by means of a recursive elective filter (RII). A variability index (Ik), is calculated which is a function of the instantaneous amplitude [vs(n)] of the discrete signal (Sk) coming from said band-pass filter. The variability index (Ik) is preferably a function of and particularly equal to the effective value of the discrete signal (Sk) from the band-pass filter.

Abstract: Process for preserving insulin secreting cells intended to be transplanted, including the following steps: introducing an initial volume of culture medium and insulin-secreting cells into a culture container, providing a culture medium source, and replacing, at time intervals below 8 hours, the culture medium in the culture container with culture medium from the source so as to renew the culture medium contained in the container.

Abstract: The present invention is related to an in vitro diagnostic assay of enteroviruses, based on the revealing of an immunologic reaction of antigen-antibody recognition type, using antigens or epitopes thereof that do not induce antiviral neutralising antibodies but induce “facilitating” antibodies which increase the viral infection.

Abstract: The eye is positioned relative to a detection device in such a manner as to co-operate with the device to form a Fabry-Perot cavity having a main optical axis and comprising two opposite reflecting faces on the main optical axis, one of these two faces being constituted by a stationary reflecting element and the other being formed by the cornea of the eye. An incident laser beam is injected into said cavity so as to be centered on the main optical axis of the Fabry-Perot cavity, the cornea is aligned laterally and longitudinally relative to the main optical axis in such a manner as to obtain longitudinal interference between the go and the return laser beams reflected between the two reflecting faces of the cavity, and an optoelectronic detector is used to detect the intensity I of said interference as a function of time. The invention is applicable to measuring intraocular pressure.

Abstract: The inventive method for processing an RR series comprises a plurality of (RR) samples representing time intervals (dti) between two successive heart beats or the inverse (1/dti) of said time intervals consists in selecting (N) (RRi) samples in a main time window having a predetermined length (n), in cutting said main window into (m) subwindows (Fj), in calculating an intermediate parameter (A1) for each subwindow (Fj) on the basis of the (RRi) samples contained in the subwindow (Fj) and in calculating a final parameter as a function of the intermediate parameters (Aj).The invention is used for analysing a cardiac rhythm variability, in particular for assessing a patient's pain or stress.

Abstract: The present invention relates to a process for obtaining mammalian insulin secreting cells in vitro, characterized in that it contains the following steps: a) preparation of the mammalian pancreatic tissues by removal of a pancreas, b) dissociation of the pancreatic tissues obtained in step (a) into isolated pancreatic cells, c) possibly the elimination of the endocrine cells from the pancreatic cells isolated in step (b), d) induction of dedifferentiation of the cells isolated in step (b) into ductal precursor cells, e) induction of redifferentiation of the ductal precursor cells obtained in step (d) into insulin secreting cells. It also concerns the use of the insulin secreting cells thus obtained for the preparation of a pharmaceutical composition which can be used for the treatment of pancreatic pathologies and particularly diabetes.