Abstract: The present invention relates to the field of muscle regeneration, and more particularly to the replenishment of the in vivo muscle stem cells pool. It more specifically relates to a 5-hydroxytryptamine B1 receptor-stimulating agent, and to a composition comprising said agent, for use as i) a promoter of satellite cells self-renewal and/or differentiation, and/or ii) an agent preventing and/or inhibiting the satellite cells pool exhaustion. The invention further encompasses therapeutic and screening methods.
Type:
Grant
Filed:
October 31, 2019
Date of Patent:
May 31, 2022
Assignees:
INSTITUT PASTEUR, UNIVERSITE PARIS DESCARTES, CENTRE HOSPITALIER SAINTE ANNE PARIS, INISTITI IT GI ISTAV/E Dm ICCV
Inventors:
Fabrice Bruno Chretien, Raphael Gaillard, Pierre Rocheteau, Olivier Mir
Abstract: The present invention relates to the field of regenerative medicine, and more particularly to the improvement of the in vivo engraftment potential of biological material to be administered to a subject in need thereof.
Type:
Grant
Filed:
June 15, 2016
Date of Patent:
May 25, 2021
Assignees:
INSTITUT PASTEUR, UNIVERSITE PARIS DESCARTES, CENTRE HOSPITALIER SAINTE ANNE PARIS
Inventors:
Fabrice Bruno Chretien, Raphael Gaillard, Pierre Rocheteau
Abstract: The present invention relates to the field of muscle regeneration, and more particularly to the replenishment of the in vivo muscle stem cells pool. It more specifically relates to a 5-hydroxytryptamine B1 receptor-stimulating agent, and to a composition comprising said agent, for use as i) a promoter of satellite cells self-renewal and/or differentiation, and/or ii) an agent preventing and/or inhibiting the satellite cells pool exhaustion. The invention further encompasses therapeutic and screening methods.
Type:
Grant
Filed:
July 15, 2016
Date of Patent:
December 3, 2019
Assignees:
UNIVERSITE PARIS DESCARTES, CENTRE HOSPITALIER SAINTE ANNE PARIS, INSTITUT GUSTAVE-ROUSSY, INSTITUT PASTEUR
Inventors:
Fabrice Bruno Chretien, Raphael Gaillard, Pierre Rocheteau, Olivier Mir