Abstract: The present invention relates to a compound of the following general formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug, particularly intended for inhibiting a programmed cell death route selected from the group consisting of ferroptosis, oxytosis and cellular necroptosis. The present invention also relates to a compound of general formula (I) for use as a drug for neuroprotection as well as for preventing and/or treating disorders associated with cellular necroptosis or ferroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.

Abstract: The present invention relates to a compound of the following general formula (I); or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug, particularly intended for inhibiting a programmed cell death route selected from the group consisting of ferroptosis, oxytosis and cellular necroptosis. The present invention also relates to a compound of general formula (I) for use as a drug for neuroprotection as well as for preventing and/or treating disorders associated with cellular necroptosis or ferroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.

Abstract: Disclosed is a medico-surgical simulator and to a corresponding method. The medico-surgical simulator includes a vascularization device and/or a ventilation device, as well as a regulation device. The medico-surgical simulator is arranged so as to be connected to a cadaver and to vascularize an arterial system of the cadaver via the vascularization device and/or to ventilate a respiratory system of the cadaver via the ventilation device. The regulation device controls the vascularization and ventilation devices in such a way as to simulate cardiorespiratory functions for providing surgical training carried out on the cadaver with a very high degree of realism.

Abstract: A method for mapping painful zones, includes: on a first screen, displaying a first silhouette representing the rear face of a body; drawing at least one painful zone on the first displayed silhouette; indicating the location of a pain felt by a patient; determining a first number of pixels on the first screen corresponding to the painful zone; measuring a reference distance between two morphological reference points on the patient; converting the first number of pixels into a painful cutaneous surface, the reference distance being used as a parameter in the conversion.

Abstract: In order to assist in evaluating/monitoring pain, a touch-sensitive graphics tool (TG) is provided with a local application (TGapps) for displaying a graphical representation of a patient's body, on which the patient can delimit a zone. A control application cooperates with the local application (TGapps) in order to record each delimited zone together with the corresponding surface data. The control application is configured to control a patient auto-calibration function that can determine deviations between a plurality of target points designated by contact on the patient's physical body and the corresponding points that the patient points to on the graphical representation displayed on the screen. The delimitation by the patient of a zone on the graphical representation is altered according to the patient auto-calibration deviations.

Abstract: A composition for protecting and/or preserving cells, tissues or organs, includes at least one cyclodextrin, preferably closely combined with an antioxidant. A process for producing this composition and its uses are also disclosed.

Abstract: The object of the invention is a composition for protecting and/or preserving cells, tissues or organs, characterized in that it comprises at least one cyclodextrin, preferably closely combined with an antioxidant. The invention also relates to a process for producing this composition and its uses.