Patents Assigned to CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS (CHUV)
  • SINGLE VESSEL EXPANSION OF LYMPHOCYTES
    Publication number: 20240287454
    Abstract: The present invention relates to a population of lymphocytes comprising at least 90% CD3+ T cells and less than 5% B cells, wherein at least 70% of said T cell portion are viable, at least 20% are CD27/CD28 double positive and less than 10% are triple positive for CD45RA, CD57 and KLRG1 and a method for expansion of a population of lymphocytes specific for one or more antigens comprising a single culture phase.
    Type: Application
    Filed: April 29, 2022
    Publication date: August 29, 2024
    Applicants: TIGEN PHARMA SA, LUDWIG INSTITUTE FOR CANCER RESEARCH LTD, CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS (CHUV)
    Inventors: George Coukos, Alexandre Harari, Simone Steiner, Florence Salmon
  • SURGICAL SYSTEM FOR MINIMALLY INVASIVE TREATMENT OF A TRIGGER FINGER
    Publication number: 20240225687
    Abstract: The invention relates to a surgical device to be used in orthopaedic treatment. In particular, the present invention relates to a surgical system for minimally invasive treatment of a trigger finger.
    Type: Application
    Filed: February 16, 2022
    Publication date: July 11, 2024
    Applicant: Centre Hospitalier Universitaire Vaudois (CHUV)
    Inventors: Debora Schivo, Sebastien Durand, Didier Maillefer, Severino Tehrani
  • SURGICAL SYSTEM FOR MINIMALLY INVASIVE TREATMENT OF A TRIGGER FINGER
    Publication number: 20240130758
    Abstract: The invention relates to a surgical device to be used in orthopaedic treatment. In particular, the present invention relates to a surgical system for minimally invasive treatment of a trigger finger.
    Type: Application
    Filed: February 16, 2022
    Publication date: April 25, 2024
    Applicant: Centre Hospitalier Universitaire Vaudois (CHUV)
    Inventors: Debora Schivo, Sebastien Durand, Didier Maillefer, Severino Tehrani
  • IL-26 inhibitors
    Patent number: 10751416
    Abstract: The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with interleukin 26 (IL-26), including inflammatory diseases, such as psoriasis and/or bacterial infections.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: August 25, 2020
    Assignees: CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS (CHUV), BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Michel Gilliet, Jeremy Di Domizio, Stephan Meller
  • IL-26 INHIBITORS
    Publication number: 20180207271
    Abstract: The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with interleukin 26 (IL-26), including inflammatory diseases, such as psoriasis and/or bacterial infections.
    Type: Application
    Filed: July 13, 2016
    Publication date: July 26, 2018
    Applicants: CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS (CHUV), BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Michel GILLIET, Jeremy DI DOMIZIO, Stephan MELLER
  • GENOME EDITING FOR THE TREATMENT OF HUNTINGTON'S DISEASE
    Publication number: 20170224843
    Abstract: A treatment of Huntington's disease (HD) using the Clustered-Regularly Interspaced Short Palindromic Repeats (CRISPR) system. This technology offers the possibility to design a small RNA (sgRNA), which is incorporated into a CRISPR-associated protein (Cas9) to recognize and induce DNA double-strand breaks at a specific target location. In the context of HD, this allows to block the expression of the mutant huntingtin or repair the CAG expansion causing the disease.
    Type: Application
    Filed: August 4, 2015
    Publication date: August 10, 2017
    Applicant: CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS (CHUV)
    Inventors: Nicole DEGLON, Nicolas MERIENNE
  • Preparation of parental cell bank from foetal tissue
    Patent number: 9434923
    Abstract: The present invention relates to methods of in vitro preparation of a parental cell bank (PCB) from foetal tissue consisting of foetal epiphyseal tissue, foetal Achilles tendon tissue and foetal skin tissue, using a rapid mechanical primary cell culture selection of cell type to be used in methods for wound and tissue repair.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: September 6, 2016
    Assignee: CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS (CHUV)
    Inventor: Lee Ann Laurent-Applegate
  • deficient in endogenous secreted protease
    Patent number: 8703444
    Abstract: The present invention relates to micro-organisms and to methods of producing proteins. More specifically, the inventions relates to a host cell useful for the expression of heterozygous proteins in which the host cell, Pichia pastoris, has been genetically modified so that the gene for endogenous secreted subtilisin Sub2 protease is completely or partially inactivated.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: April 22, 2014
    Assignee: Centre Hospitalier Universitaire Vaudois (CHUV)
    Inventor: Michel Monod
  • PICHIA PASTORIS DEFICIENT IN ENDOGENOUS SECRETED PROTEASE
    Publication number: 20120295307
    Abstract: The present invention relates to micro-organisms and to methods of producing proteins. More specifically, the inventions relates to a host cell useful for the expression of heterozygous proteins in which the host cell, Pichia pastoris, has been genetically modified so that the gene for endogenous secreted subtilisin Sub2 protease is completely or partially inactivated.
    Type: Application
    Filed: December 13, 2010
    Publication date: November 22, 2012
    Applicant: CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS (CHUV)
    Inventor: Michel Monod
  • SYNERGIC ACTION OF A PROLYL PROTEASE AND TRIPEPTIDYL PROTEASES
    Publication number: 20120276075
    Abstract: The present invention relates to a novel enzyme composition comprising a prolyl protease and tripeptidyl proteases having unique catalytic properties. The present invention further relates to methods for producing the enzyme composition as well as a pharmaceutical composition and a food supplement containing the enzyme composition and its use in the degradation of polypeptides.
    Type: Application
    Filed: December 20, 2010
    Publication date: November 1, 2012
    Applicant: CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS (CHUV)
    Inventors: Michel Monod, Eric Grouzmann