Abstract: Provided herein are compounds (e.g., compounds of Formulae (I), (II), and (III)) which are anti-fungal agents and can be used in the treatment of diseases, including infectious diseases. The invention provides methods of treating diseases in a subject (e.g., infectious diseases such as fungal infections), and methods of killing or inhibiting the growth of fungi in or on a subject or biological sample. The compounds may be used in subjects, in clinical settings, or in agricultural settings.

Abstract: Selectively exciting bulk protons in certain tissue components, e.g. water, while suppressing the excitation of others, e.g. fat, can lead to images with better contrast for desired features. The invention provides binomial, off-resonance RF excitation pulses for differentiating tissue excitation that yields a larger fat suppression that prior art water excitation methods. Proper balancing of the frequency offset and the pulse duration with a relative phase offset between the pulses leads to large-bandwidth pass- and stopbands for water and fat, respectively. The pulses can be applied with short, or even zero, interpulse delay, leading to substantial time savings in the imaging sequence.

Abstract: The invention relates to chemoembolization compositions for anti-angiogenic agent delivery. The invention further relates to a method of preparing chemoembolization compositions and to the use of chemoembolization compositions in the method for treating solid tumour cancers.

Abstract: This disclosure relates to binding agents with specificity for HIV and to methods for using the same to treat, prevent and/or ameliorate HIV infection and/or AIDS.

Abstract: The invention relates to methods promoting the aggregation of Salmonella bacteria in the gut of subjects, thereby providing immune exclusion and limiting bacterial entry, therefore reducing mucosal and systemic infection.

Abstract: The present invention relates generally to a pharmaceutical formulation for use in the treatment and/or prevention of restenosis in a subject in need thereof. Methods of treatment and/or prevention are also provided.

Abstract: The present invention relates to a method for predicting awakening in a comatose patient based on the progression of auditory discrimination during early stages of coma. EEG measures are acquired from the patient during two distinct periods when said patient is exposed to auditory stimuli comprising repeated standard and deviant sounds. The first period occurs when the comatose patient is in a hypothermia state and the second period occurs when the comatose patient is in a normal temperature state and preferably within 2-3 days from the onset of the coma. The present invention further relates to a computer-implemented method thereof.

Abstract: A method improves a detection of a brain tissue pathology in magnetic resonance (MR) images of a patient. The method includes acquiring multiple MR imaging data for creating four different contrast maps of a patient brain. From the multiple MR imaging data, performing an estimation of gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF) concentration for each voxel of a part of the patient brain. From the multiple MR imaging data, segmenting the part of the patient brain in different regions-of-interest (ROIs) according to a chosen atlas. For each voxel of each of the contrast maps of the patient brain, computing, for the part of the patient brain, a deviation score. The method further includes creating from the deviation score and for each of the quantitative contrast maps, a deviation map representing the part of the brain in dependence on the deviation score calculated for each voxel.

Abstract: The invention is in the field of analysis of cell populations and cell separation and the compositions obtained thereby. More particularly, the invention concerns a method for separating cells of interest according to a specific marker expressed on their surface.

Abstract: The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with interleukin 26 (IL-26), including inflammatory diseases, such as psoriasis and/or bacterial infections.

Abstract: The present invention relates to a pharmaceutical composition comprising a live attenuated non-recombinant mutant of Salmonella enterica serovar typhi strain and/or a non-viable attenuated non-recombinant mutant of Salmonella enterica serovar typhi strain for use the treatment of cancer recurrence/progression. Preferably the cancer is bladder cancer.

Abstract: A treatment of Huntington's disease (HD) using the Clustered-Regularly Interspaced Short Palindromic Repeats (CRISPR) system. This technology offers the possibility to design a small RNA (sgRNA), which is incorporated into a CRISPR-associated protein (Cas9) to recognize and induce DNA double-strand breaks at a specific target location. In the context of HD, this allows to block the expression of the mutant huntingtin or repair the CAG expansion causing the disease.

Abstract: The invention relates to chemoembolization composition for anti-angiogenic agent delivery. The invention further relates to a method of preparing chemoembolization composition and to the use of chemoembolization composition in the method for treating solid tumor cancers.

Abstract: The disclosure relates to recombinant vectors and methods for using the same. In certain embodiments, the recombinant vectors are immunogenic.

Abstract: The present invention concerns an actuating device for actuating a mechanical adjustment element of surgical implant, said mechanical adjustment element allowing to modify the functional shape and/or the functional size of the surgical implant when actuated, said actuating device comprising transmission means linked with one end to the mechanical adjustment element and able to move the mechanical adjustment element when said transmission means are actuated, connecting means (7) mounted on the other end of the transmission means and able to actuate the transmission means, said connecting means (7) comprising coupling means and driving means (24) comprising complementary shaped coupling means, said driving means (24) being designed to be removable and fitted into the coupling means for moving the mechanical adjustment element by driving into movement a movable part of the connecting means (7).

Abstract: The present invention relates to methods of in vitro preparation of a parental cell bank (PCB) from foetal tissue consisting of foetal epiphyseal tissue, foetal Achilles tendon tissue and foetal skin tissue, using a rapid mechanical primary cell culture selection of cell type to be used in methods for wound and tissue repair.

Abstract: The present invention relates to a multi-well filter plate able to facilitate, simplify and accelerate preparation and treatment of samples to be analyzed by for example liquid chromatography tandem mass spectrometry (UPLC—MS/MS method for simultaneous quantification of analytes).

Abstract: An annuloplasty ring system for repairing an atrioventricular cardiac valve includes an external support ring (2), an inner adjustable ring (4), a sliding pushing element (6) mounted between the external and inner rings (2, 4), and actuating element designed to control the pushing element (6). The pushing element (6) is designed, when actuated by the actuating element, to slide between the external ring (2) and the inner ring (4) and to press on the inner ring (4) by using the external ring (2) as a support, in such a way that a precise part of the inner ring (4) is deformed without modifying the perimeter of the inner ring (4).

Abstract: The present invention concerns a method of detecting the presence of a DNA minor contributor in a DNA mixture by determining several haplotypes present in said one or more DNA samples.

Abstract: The present invention relates to methods of in vitro preparation of a parental cell bank (PCB) from foetal tissue consisting of foetal epiphyseal tissue, foetal Achilles tendon tissue and foetal skin tissue, using a rapid mechanical primary cell culture selection of cell type to be used in methods for wound and tissue repair.