Abstract: The use of at least one &ggr;-RAR receptor-specific agonist ligand to prepare a pharmaceutical composition for increasing the rate of apoptosis in at least one cell population in which apoptosis may be induced by activating &ggr;-RAR receptors is disclosed. The composition is particularly useful for treating a disease or disorder related to an insufficient rate of apoptosis in at least one cell population in which apoptosis may be induced by activating &ggr;-RAR receptors. The use of at least one &ggr;-RAR receptor-specific agonist ligand as the apoptosis inducer in a cosmetic composition is also disclosed. Said composition may be used to prevent and/or control photo-ageing or chronological ageing of the skin.
Type:
Grant
Filed:
July 15, 1998
Date of Patent:
July 15, 2003
Assignee:
Centre International de Recherches Dermatologioues Galderma
(C.I.R.D. Galderma)
Abstract: The present invention provides novel heteroaryl compounds having the general formula (I): ##STR1## their pharmaceutical compositions to be used as human and veterinary medicine, particularly in the treatment of dermatological, rheumatic, respiratory, cardiovascular and ophthalmologic conditions, and their use in cosmetic compositions.
Type:
Grant
Filed:
October 13, 1998
Date of Patent:
February 29, 2000
Assignee:
Centre International de Recherches Dermatologioues galderma