Abstract: The invention relates to novel bicyclic aromatic compounds which have the general formula (I):
as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.
Type:
Grant
Filed:
September 12, 2000
Date of Patent:
February 4, 2003
Assignee:
Centre International de Recherches Dermatologiques
Galderma
Abstract: Methods of cosmetically or therapeutically treating diseases or disorders in cell populations whose pathology is linked to an inadequate rate of apoptosis by administering a therapeutically effective amount of 6-3-(1-adamantyl)-4-hydroxyphenyl)-2-naphthanoic acid.
Type:
Grant
Filed:
July 25, 2000
Date of Patent:
January 14, 2003
Assignee:
Centre International de Recherches Dermatologiques
Galderma
Abstract: The invention relates to novel biaromatic compounds having general formula I
and their use in pharmaceutical compositions for use in human and veterinary medicine, in particular for treating dermatological, rheumatic, respiratory, cardiovascular, and ophthalmological disorders, and for use in cosmetic compositions.
Type:
Grant
Filed:
November 17, 1997
Date of Patent:
July 10, 2001
Assignee:
Centre International de Recherches Dermatologiques
Galderma
Abstract: The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and atherosclerosis, is stimulated by treating such preadipocytic cells, or a patient in need of such treatment, with an effective amount of (a) at least one ligand displaying affinity for the nuclear receptors for retinoic acid and/or isomers thereof, preferably at least one ligand displaying a specific affinity for the RAR receptors and even more preferably the RAR-&agr; receptor and (b) at least one fatty acid, e.g., a polyunsaturated fatty acid.
Type:
Grant
Filed:
August 3, 1998
Date of Patent:
June 19, 2001
Assignee:
Centre International de Recherches Dermatologiques
Galderma
Abstract: The invention concerns tye use of a inhibitor of retinoic acid as sole ingredient in a pharmaceutical or cosmetic composition comprising administering effective amount of the composition to treat sensitive skin or skin damage induced by UV radiation.
Type:
Grant
Filed:
September 4, 1998
Date of Patent:
June 19, 2001
Assignee:
Centre International de Recherches Dermatologiques
Galderma
Abstract: Methods for treating or preventing breast cancer or leukemia in subjects in need of such treatment are provided which involve the administration of 6-[3-[1-adamantyl]-4-hydroxyphenyl]-2-naphthalene carboxylic acid (AHPN), a retinoid which induces G0/G1 arrest and apoptosis. These methods are useful for treatment of breast cancers which express or do not express estrogen receptors.
Type:
Grant
Filed:
June 29, 1998
Date of Patent:
April 3, 2001
Assignee:
Centre International de Recherches Dermatologiques
Galderma
Abstract: Novel pharmaceutically/cosmetically-active polyaromatic heterocyclic compounds have the structural formula (I):
in which Z is a divalent radical selected from among —O—, —S— or —Nr′— and Ar is either a radical having the following structural formula (II):
or a radical having the following structural formula (III):
and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
Type:
Grant
Filed:
July 23, 1998
Date of Patent:
February 27, 2001
Assignee:
Centre International de Recherches Dermatologiques
Galderma
Inventors:
Bruno Charpentier, Philippe Diaz, Philippe Nedoncelle
Abstract: Novel pharmaceutically/cosmetically-active biaromatic amido compounds have the structural formula (I):
in which Ar is a radical selected from among those of the following formulae (a)-(e):
and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
Type:
Grant
Filed:
February 9, 1999
Date of Patent:
January 9, 2001
Assignee:
Centre International de Recherches Dermatologiques
Galderma
Abstract: Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural formula (I): in which X is one of the radicals: ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
Type:
Grant
Filed:
October 6, 1997
Date of Patent:
December 19, 2000
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds having the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## which are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders are provided. In particular, based on their RXR-agonist activity, these compounds may be used to treat noninsulin-dependent diabetes mellitus (NIDDM) and obesity.
Type:
Grant
Filed:
September 10, 1998
Date of Patent:
December 19, 2000
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
Type:
Grant
Filed:
January 13, 1999
Date of Patent:
December 5, 2000
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
Type:
Grant
Filed:
August 9, 1999
Date of Patent:
December 5, 2000
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: The invention relates to novel bicyclic aromatic compounds which have the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.
Type:
Grant
Filed:
January 26, 1998
Date of Patent:
November 14, 2000
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: The invention concerns novel bi-aromatic dibenzofuran derivatives of formula (I),and their use in pharmaceutical compositions for human or veterinary medicine (skin, rheumatic respiratory, cardiovascular, and ophthalmologic disorders), or in cosmetic compositions as well. The X, Ar, R.sub.1 and R.sub.2 in formula (I) are defined in the specification.
Type:
Grant
Filed:
September 4, 1998
Date of Patent:
May 2, 2000
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: The invention relates to novel propynyl or dienyl biaromatic compounds which have the general formula (I) ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.
Type:
Grant
Filed:
January 26, 1998
Date of Patent:
April 4, 2000
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
Type:
Grant
Filed:
November 17, 1997
Date of Patent:
January 18, 2000
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: The present invention relates to the use of at least one ligand which is specific for RXR receptors, in the preparation of a pharmaceutical composition to be administered systemically and intended to increase the cellular proliferation and/or differentiation modulatory activity of a ligand for at least one receptor of the superfamily of steroidal/thyroidal receptors, other than a ligand which is specific for the RXR receptors, and which can heterodimerize with the RXRs, which is applied topically.
Type:
Grant
Filed:
June 19, 1996
Date of Patent:
December 21, 1999
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
Type:
Grant
Filed:
January 9, 1998
Date of Patent:
November 16, 1999
Assignee:
Centre International De Recherches Dermatologiques Galderma
Abstract: The invention relates to novel heterocyclic biaryl compounds which have the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.
Type:
Grant
Filed:
November 24, 1997
Date of Patent:
November 9, 1999
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: Novel pharmaceutically/cosmetically-active aromatic polyenic compounds have the structural formula (I):
and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, bone and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
Type:
Grant
Filed:
January 5, 2000
Date of Patent:
December 31, 2002
Assignee:
Centre International de Recherches Dermatologiques
Galderma