Abstract: The invention concerns novel bi-aromatic dibenzofuran derivatives of formula (I),and their use in pharmaceutical compositions for human or veterinary medicine (skin, rheumatic respiratory, cardiovascular, and ophthalmologic disorders), or in cosmetic compositions as well. The X, Ar, R.sub.1 and R.sub.2 in formula (I) are defined in the specification.
Type:
Grant
Filed:
September 4, 1998
Date of Patent:
May 2, 2000
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: Novel pharmaceutically/cosmetically-active polyaromatic amides have the structural formula (I): ##STR1## wherein Z is a radical --CO--NH-- or --NH--CO--,and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
Type:
Grant
Filed:
November 13, 1997
Date of Patent:
April 18, 2000
Assignee:
Centre International de Recherches Dermatologiques
Abstract: The invention relates to novel propynyl or dienyl biaromatic compounds which have the general formula (I) ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.
Type:
Grant
Filed:
January 26, 1998
Date of Patent:
April 4, 2000
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
Type:
Grant
Filed:
November 17, 1997
Date of Patent:
January 18, 2000
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: The present invention relates to the use of at least one ligand which is specific for RXR receptors, in the preparation of a pharmaceutical composition to be administered systemically and intended to increase the cellular proliferation and/or differentiation modulatory activity of a ligand for at least one receptor of the superfamily of steroidal/thyroidal receptors, other than a ligand which is specific for the RXR receptors, and which can heterodimerize with the RXRs, which is applied topically.
Type:
Grant
Filed:
June 19, 1996
Date of Patent:
December 21, 1999
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: The retinoids, in particular the anti-AP-1 retinoids, effectively inhibit the expression of VEGF, and thus are useful for the therapeutic treatment of disease states manifesting an overexpression of VEGF.
Type:
Grant
Filed:
September 2, 1997
Date of Patent:
December 14, 1999
Assignee:
Centre International de Recherches Dermatologiques
Inventors:
Barbara Vega, Serge Michel, Annie Ladoux, Christian Frelin
Abstract: Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
Type:
Grant
Filed:
January 9, 1998
Date of Patent:
November 16, 1999
Assignee:
Centre International De Recherches Dermatologiques Galderma
Abstract: The invention relates to novel heterocyclic biaryl compounds which have the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.
Type:
Grant
Filed:
November 24, 1997
Date of Patent:
November 9, 1999
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: A method for promoting healing by administration of an inhibitor of the activity of retinoic acid is provided. Preferred compounds for use in such treatment include antagonists of retinoic acid. The method is particularly applicable for promoting skin healing and treatment of surgical and traumatic wounds.
Type:
Grant
Filed:
July 28, 1998
Date of Patent:
October 26, 1999
Assignee:
Centre International de Recherches Dermatologiques Galderma
Inventors:
Michel Demarchez, Patricia Rossio, Andre Jomard
Abstract: Pharmaceutically/cosmetically-active adamantyl-substituted retinoid compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formula (a) - (d): ##STR2## and are useful for the treatment of disorders and/or ailments manifesting an overregulation of RAR receptors and/or a hypervitaminosis A.
Type:
Grant
Filed:
May 3, 1996
Date of Patent:
September 14, 1999
Assignee:
Centre International De Recherches Dermatologiques Galderma
Abstract: Pigmentation of the skin, hair and/or nails of individuals is promoted by administering thereto, advantageously topically and advantageously in combination with enzymes exhibiting tyrosinase activity, effective pigmentation-promoting amounts of at least one retinoid compound which comprises a phenolic or naphtholic functional group.
Type:
Grant
Filed:
February 10, 1998
Date of Patent:
August 24, 1999
Assignee:
Centre International de Recherches Dermatologiques
Inventors:
Philippe Diaz, Bruno Charpentier, Braham Shroot
Abstract: Nongreasy, nonsticky cosmetic and/or dermatological compositions for topical application to human skin and/or hair, characteristically without imparting a shiny appearance thereto, contain at least one fatty substance and an amount of deformable hollow particulates effective to avoid the greasy and/or sticky feel otherwise attributable to the at least one fatty substance, said deformable hollow particulates comprising a copolymer of vinylidene chloride, acrylonitrile and a (meth)acrylic comonomer and having a particle size ranging from 1 .mu.m to 250 .mu.m.
Type:
Grant
Filed:
June 9, 1997
Date of Patent:
August 17, 1999
Assignee:
Centre International de Recherches Dermatologiques Galderma
Inventors:
Josiane Allec, Eve Ferrara, Isabelle Bara
Abstract: Novel pharmaceutically/cosmetically-active biaromatic amido compounds have the structural formula (I): ##STR1## in which Ar is a radical selected from among those of the following formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
Type:
Grant
Filed:
February 23, 1996
Date of Patent:
August 10, 1999
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: Novel pharmaceutically/cosmetically-active polycyclic polyenic compounds have the structural formula (I): ##STR1## and are useful for modulating cellular hormone receptors.
Type:
Grant
Filed:
September 2, 1997
Date of Patent:
June 8, 1999
Assignee:
Centre International De Recherches Dermatologiques Galderma
Abstract: Novel pharmaceutically/cosmetically-active heterocyclic biaryl compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(h): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for cosmetic applications and for the treatment of mammalian skin and hair conditions/disorders.
Type:
Grant
Filed:
June 30, 1997
Date of Patent:
May 18, 1999
Assignee:
Centre International De Recherches Dermatologiques Galderma
Abstract: The present invention relates to new aromatic compounds, to their preparation and to their use in human and veterinary medicine and in cosmetic compositions.
Type:
Grant
Filed:
September 26, 1994
Date of Patent:
February 9, 1999
Assignee:
Centre International De Recherches Dermatologiques Galderma (CIRD Galderma)
Abstract: Topically applicable cosmetic/dermatological compositions well suited for the therapeutic treatment or care of human skin, nails, hair and/or of the scalp, in particular for treating and/or preventing xerosis, ichthyosis, actinic keratosis and/or photoinduced cutaneous aging, comprise a water-in-oil emulsion containing (a) at least 10% by weight of at least one hydroxy acid, (b) an effective emulsifying amount of at least one polyoxyalkylenated silicone, and (c) an effective coemulsifying amount of at least one polyol alkyl ester, polyol alkyl ether or oxyalkylenated alkyl ether, with the proviso that the subject compositions are devoid of any C.sub.1 -C.sub.4 alkanol.
Type:
Grant
Filed:
December 14, 1995
Date of Patent:
January 26, 1999
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and atherosclerosis, is stimulated by treating such preadipocytic cells, or a patient in need of such treatment, with an effective amount of (a) at least one ligand displaying affinity for the nuclear receptors for retinoic acid and/or isomers thereof, preferably at least one ligand displaying a specific affinity for the RAR receptors and even more preferably the RAR-.alpha. receptor and (b) at least one fatty acid, e.g., a polyunsaturated fatty acid.
Type:
Grant
Filed:
January 22, 1997
Date of Patent:
December 29, 1998
Assignee:
Centre International De Recherches Dermatologiques Galderma
Abstract: Novel pharmaceutically/cosmetically-active polyaromatic heterocyclic compounds have the structural formula (I): ##STR1## in which Z is a divalent radical selected from among --O--, --S-- or --Nr'-- and Ar is either a radical having the following structural formula (II): ##STR2## or a radical having the following structural formula (III): ##STR3## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
Type:
Grant
Filed:
March 14, 1996
Date of Patent:
December 15, 1998
Assignee:
Centre International De Recherches Dermatologiques Galderma
Inventors:
Bruno Charpentier, Philippe Diaz, Philippe Nedoncelle
Abstract: The invention relates to the use of metronidazole, or preferably of a combination of metronidazole and clindamycin, as active principle for the manufacture of pharmaceutical compositions, more particularly dermatological compositions, intended for an anti-inflammatory treatment by the topical route.
Type:
Grant
Filed:
March 25, 1997
Date of Patent:
December 15, 1998
Assignee:
Centre International de Recherches Dermatologiques Galderma (C.I.R.D. Galderma)
Inventors:
Janusz Czernielewski, Josiane Allec, Martine Bouclier