Patents Assigned to Centre National de la Recherché Scientifique (CNRS)
  • Benzoimidazole Derivatives As Anticancer Agents
    Publication number: 20220348587
    Abstract: The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing the compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.
    Type: Application
    Filed: June 3, 2022
    Publication date: November 3, 2022
    Applicants: CENTRE LEON BERARD, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Toufic RENNO, Isabelle COSTE-INVERNIZZI, Stéphane GIRAUD, Serge LEBECQUE
  • Isomorphous substitution of metals on synthesized zeolite framework
    Patent number: 11485643
    Abstract: The present disclosure relates to a novel method for introducing various metals in the structure of zeolite frameworks by isomorphous substitution. This new method is based on a hydrothermal reaction of the metal with the zeolite. This method allows obtaining zeolite with a structure and with control of the metal location.
    Type: Grant
    Filed: October 13, 2020
    Date of Patent: November 1, 2022
    Assignees: TOTALENERGIES ONETECH, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Cindy Aquino, Svetlana Mintova, Jean-Pierre Gilson, Florent Dubray, Delphine Minoux, Julien Grand, Nikolai Nesterenko
  • SURGERY-ASSISTANCE DEVICE
    Publication number: 20220338954
    Abstract: A device for assisting surgery includes means for offsetting a rotation of a first type and a second type, a mechanism for transmitting a rotation of a third type, and a mechanism for transforming the rotation of a third type into a translation. An elastic element is connected at one end to the mechanism for transmitting the rotation of a third type. The mechanism for transmitting the rotation of a third type is connected to a rotary motor, the rotation of the motor in a first direction causing the lowering of a tool and an elongation of the elastic element, the rotation of the motor in a second direction causing the raising of the tool and a contraction of the elastic element, and, when the tool is lowered and the rotary motor is not exerting any torque, the elastic element returns to an initial shape causing the raising of the tool.
    Type: Application
    Filed: September 22, 2020
    Publication date: October 27, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, CHU DE NANTES
    Inventors: Damien CHABLAT, Guillaume MICHEL, Philippe BORDURE
  • DIGITAL BIOMOLECULES DETECTION AND/OR QUANTIFICATION USING ISOTHERMAL AMPLIFICATION
    Publication number: 20220333177
    Abstract: The present invention relates to a digital method for detecting and/or quantifying at least one target biomolecules in a sample, said biomolecules being selected from DNA, RNA, and proteins based on isothermal amplification. The present invention further relates to different applications of the digital method and to a kit.
    Type: Application
    Filed: May 27, 2020
    Publication date: October 20, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, PARIS SCIENCES ET LETTRES, UNIVERSITE DE PARIS
    Inventors: Yannick RONDELEZ, Guillaume GINES, Roberta LIMA DE CASTRO MENEZES, Valérie TALY
  • Methods for determining whether a patient suffering from rhabdomyolysis achieves a response with a TLR9 antagonist
    Patent number: 11473145
    Abstract: The inventors initially participated to the identification of LPIN1 mutations as a cause for massive rhabdomyolysis episodes in children, triggered by febrile illness. The inventors have suggested that TLR9 antagonists would be suitable for the treatment of rhabdomyolysis (WO2017085115). The inventors thus treated 2 patients with lipin-1 disease by a TRL9 antagonist (hydroxychloroquine). They showed that the accumulation of mtDNA in plasma of the two patients before treatment decreases under treatment. When the treatment was stopped, the accumulation of mtDNA reappeared, then normalized when treatment was resumed. Accordingly, the present invention relates to a method for determining whether a patient suffering from rhabdomyolysis achieves a response with a TLR9 antagonist comprising determining the amount of mitochondrial DNA (mtDNA) in a blood sample obtained from the patient (e.g. by PCR).
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: October 18, 2022
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), FOUNDATION IMAGING, ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ DE PARIS
    Inventors: Pascale De Lonlay-Debeney, Peter Van Endert, Marine Madrange, Yamina Hamel, François-Xavier Mauvais
  • Turbine engine part coated in a thermal barrier, and a method of obtaining it
    Patent number: 11466370
    Abstract: A turbine engine part coated in at least a first ceramic layer forming a thermal barrier and including a ceramic material with first ceramic fibers dispersed in the first layer. The first layer may have a chemical composition gradient between a material for forming a thermal barrier and a material for providing protection against calcium and magnesium aluminosilicates, which is present at a greater content in an outer zone of the first layer, and/or the first layer may be porous and may present a porosity gradient such that an outer portion of the first layer presents lower porosity.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: October 11, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PAUL SABATIER—TOULOUSE III, SAFRAN AIRCRAFT ENGINES, SAFRAN
    Inventors: Aurélien Joulia, André Hubert Louis Malie, Florence Ansart, Elodie Marie Delon, Sandrine Duluard
  • SOLVENT TRANSFER PRINTING METHOD
    Publication number: 20220314686
    Abstract: Solvent transfer printing method for applying a pattern (1) made of a non-soluble material and non-dispersible (10) on the surface of an object (2), the method comprising the following steps: m1/forming a pattern (1) on a surface of a solvent-soluble substrate (3), m2/depositing the solvent-soluble substrate (3) on the surface of a solvent bath (5), on the side of the substrate opposed to the side on which the pattern is applied, in order to dissolve partially the substrate (3), m3/dipping the object (2) in the bath (5), so that the surface of the object (2) comes into contact with the pattern (1), m4/getting the object (2), on which the pattern (1) is applied, out of the bath (5), m5/drying the object (2).
    Type: Application
    Filed: May 23, 2022
    Publication date: October 6, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, UNIVERSITE DE RENNES 1
    Inventors: Maxime HARNOIS, Jacques EMMANUEL, Brice LE BORGNE
  • Movement amplifying actuation device
    Patent number: 11463020
    Abstract: A movement amplifying actuation device may include two piezoelectric beams, one beam being attached at a fixed point, and a hinge connecting a first beam and a second beam between them. Each hinge may include a first flexible portion connected to the first beam, a second flexible portion connected to the second beam, a first rigid portion connecting the first and second flexible portions, a second rigid portion capable of being positioned against a fixed point, and a third flexible portion connecting the second beam to the second rigid portion at a pivot point of the second beam such that the assembly formed by the second rigid portion and the second beam forms a lever around the pivot point. The flexible and rigid portions may form a single piece.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: October 4, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE FRANCHE-COMTE, ECOLE NATIONALE SUPERIEURE DE MECANIQUE ET DES MICROTECHNIQUES
    Inventors: Sergio Lescano, Nicolas Andreff, Micky Rakotondrabe, Kanty Rabenorosoa, Brahim Tamadazte, Clément Bouderlique
  • Methods and devices for full-field ocular blood flow imaging
    Patent number: 11457806
    Abstract: According to a first aspect, the present disclosure relates to a digital holography device (100) for full-field blood flow imaging of ocular vessels of a field of view of a layer (11) of the eye (10). The device comprises an optical source (101) configured for the generation of an illuminating beam (Eobj) and a reference beam (ELO), and a detector (135) configured to acquire a plurality of interferograms (I(x,y,t)) wherein an interferogram is defined as the signal resulting from the interference between the said reference beam (ELO) and a part of said illuminating beam (Eobj) that is backscattered from said layer (11).
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: October 4, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Léo Puyo, Michael Atlan
  • NOVEL DIZOCILPINE DERIVATIVES AS PERIPHERAL NMDA RECEPTOR ANTAGONISTS
    Publication number: 20220280498
    Abstract: The present invention relates to compounds of formula (I): for use as peripheral NMDA receptor antagonists.
    Type: Application
    Filed: May 26, 2022
    Publication date: September 8, 2022
    Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS SUD, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (APHP), HOPITAL MARIE LANNELONGUE
    Inventors: Sylvia COHEN-KAMINSKY, Marc HUMBERT, Sebastien DUMAS, Gilles BRU-MERCIER, Samir MESSAOUDI, Jean-Daniel BRION, Mouad ALAMI, Gilles GALVANI
  • PROTEIN HYDROLYSATE DERIVED FROM BLUE-BACKED FISH
    Publication number: 20220279814
    Abstract: A protein hydrolysate obtained from at least one protein source from bluefish having (i) a degree of hydrolysis (DH) of at least 10%, (ii) at least 80% water-soluble protein with a molecular weight of less than 1000 Da, (iii) at least 0.3% phospholipids, and (iv) at least 0.5% DHA and EPA.
    Type: Application
    Filed: July 31, 2020
    Publication date: September 8, 2022
    Applicants: SPECIALITES PET FOOD, UNIVERSITE DE BORDEAUX, UNIVERSITÉ DE BRETAGNE OCCIDENTALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD), INSTITUT POLYTECHNIQUE DE BORDEAUX, ABYSS INGREDIENTS, INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER - IFREMER, INSTITUT NATIONAL DE LA RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
    Inventors: Fabienne GUERARD, Cloé OROY, Anne LEPOUDERE, Mathilde CHATAIGNER, Patrick ALLAUME, Anne-Laure DINEL, Corinne JOFFRE, Véronique PALLET, Fabienne LE GRAND
  • ELASTOMER COMPOSITION
    Publication number: 20220280683
    Abstract: A composition based on triblock copolymers of the ABA type, including two styrene thermoplastic terminal blocks A, and an elastomer central block B which is a saturated olefin, and at least one polyisobutene having a very low molecular weight and optionally a diblock copolymer of AB. The present composition exhibits advantageous properties which are similar to those of silicone elastomers. Also, a dressing including such an elastomeric composition.
    Type: Application
    Filed: July 30, 2020
    Publication date: September 8, 2022
    Applicants: URGO RECHERCHE INNOVATION ET DEVELOPPEMENT, UNIVERSITE DE PAU ET DES PAYS DE L'ADOUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -
    Inventors: Christophe DERAIL, Armelle RONCIN, Xavier CALLIES, Christelle Marie Aline GUILLAMAUD, Anne-Sophie DANEROL, Marie DAUX
  • PROCESS FOR POLYMERIZING A COMPOSITION IN THE PRESENCE OF A BLOCK COPOLYMER
    Publication number: 20220275136
    Abstract: The present invention relates to a process for the polymerization of a composition in the presence of at least one block copolymer, and also to the products obtained by this polymerization process. The present invention also relates to the use of the products obtained using the polymerization process which is a subject matter of the invention.
    Type: Application
    Filed: May 19, 2020
    Publication date: September 1, 2022
    Applicants: Arkema France, Centre National De La Recherche Scientifique - CNRS, UNIVERSITE DE PAU ET DES PAYS DE L'ADOUR
    Inventors: Sylvain Bourrigaud, Anne-Laure Brocas, Sylvie Cazaumayou, Laura Garcia Andujar, Maud Save, Christophe Derail, Laurent Rubatat
  • Process For Preparation Of Bioorganic Nylon Polymers And Their Use As Antibacterial Material
    Publication number: 20220267522
    Abstract: The present invention relates to new biopolymer, i.e. bioorganic nylons incorporating peptidic blocks obtained by a process of polymerization of amino peptidic blocks. The process of the invention comprises the steps of mixing amino peptidic blocks with or without a diaminoalcane and reacting the mixture according to polycondensation with a diacyl chloride in homogeneous or heterogeneous media.
    Type: Application
    Filed: March 8, 2022
    Publication date: August 25, 2022
    Applicants: Universite De Montpellier, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Jean Martinez, Ahmad Mehdi, Gilles Subra, Saïd Jebors
  • METHOD FOR MANUFACTURING A THREE-DIMENSIONAL OBJECT OR FOR MODIFYING THE SURFACE STATE OF A PREFORMED OBJECT BY PHOTO-POLYMERIZATION
    Publication number: 20220266505
    Abstract: The method for manufacturing a three-dimensional object or for modifying the surface state of a preformed object by local polymerisation of monomers or oligomers, the polymerisation being initiated by mono-photon or multi-photon absorption in an area to be polymerised, includes: —introducing into a vessel with light-transparent walls a reaction medium comprising polymerisable monomers or oligomers, a polymerisation inhibitor, an indicator of the amount of the inhibitor and a photochemical polymerisation initiator; —initiating the polymerisation of the monomers or oligomers; —indicating the amount of inhibitor present in the reaction medium; —controlling the amount of light emitted by the irradiation system relative to the amount of inhibitor indicated by the indicator; and —switching to a following zone to be polymerised by moving the object and/or the focused light beam.
    Type: Application
    Filed: July 22, 2020
    Publication date: August 25, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE D'AIX-MARSEILLE (AMU), ECOLE CENTRALE DE MARSEILLE
    Inventors: Claude Amra, Jean-Claude André, Laurent Gallais-During, Myriam Zerrad
  • SELECTIVE PROCESS FOR PREPARING SULFOXIDES BY ENZYMATIC CATALYSIS
    Publication number: 20220259624
    Abstract: The present invention relates to a selective process for preparing sulfoxides from sulfides by enzymatic catalysis, and to a composition comprising a symmetrical sulfide, an oxidoreductase enzyme catalyzing the oxidation of said symmetrical sulfide to symmetrical sulfoxide; optionally at least one cofactor C of said enzyme E; and an oxidant, which allows in particular the implementation of said process.
    Type: Application
    Filed: June 12, 2020
    Publication date: August 18, 2022
    Applicants: Arkema France, Centre National de la Recherche Scientifique (CNRS), Universite d'Aix-Marseille
    Inventors: Georges Fremy, Hugo Brasselet, Véronique Alphand, Katia Duquesne
  • Method for rejuvenating cells
    Patent number: 11414649
    Abstract: The invention relates to a method for reprogramming cells from aged donors or senescent cells to pluripotent cells that have lost marks of senescence. In particular, the invention relates to an ex vivo method for preparing induced pluripotent stem cells (iPSCs) from a target cell population comprising cells from aged donors or senescent cells, said method comprising the steps of culturing said target cell population under appropriate conditions for reprogramming said cells into iPSCs, wherein said appropriate conditions comprises increasing expression in said target cells, of at least the following reprogramming factors: Oct4, Klf4, Sox2, c-Myc, Lin28 and, optionally Nanog.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: August 16, 2022
    Assignees: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE MONTPELLIER I, UNIVERSITE MONTPELLIER II
    Inventors: Alexandre Prieur, Ollivier Milhavet, Jean-Marc Lemaitre, Laure Lapasset
  • Hydrazone derivatives for preventing or treating EBV-related cancers
    Patent number: 11406631
    Abstract: The present invention relates to novel bis-hydrazone derivatives of formula (I): wherein Ar1 and Ar2 may be identical or different and are each independently selected from the group consisting of groups of formula (II) and (III): Y1 and Z1 are independently CH or NRc+, provided that al least one of Y1 and Z1 is NRc+ and at least one of Y1 and Z1 is CH, and Ra, Rb, Rc, X2? and L as defined in the claims, or a hydrate or a solvate thereof. Compositions and kits comprising same are also described. Said bis-hydrazone derivatives of formula (I), compositions and kits are useful as drugs, in particular for treating or preventing cancers associated with the Epstein-Barr Virus.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: August 9, 2022
    Assignees: Centre National de la Recherche Scientifique (CNRS)
    Inventors: Marc Blondel, Alicia Quillevere, Cécile Voisset, Maria José Lista, Robin Fahraeus, Chrysoula Daskalogianni, Rodrigo Prado-Martins, Marie-Paule Teulade-Fichou, Anton Granzhan, Claire Beauvineau, Oksana Reznichenko
  • METHOD FOR MANUFACTURING A PART MADE OF A MONOCRYSTALLINE SUPERALLOY
    Publication number: 20220243312
    Abstract: The invention concerns a method for manufacturing an aircraft part, the part comprising a monocrystalline nickel-based superalloy substrate, the method consecutively implementing the steps of moulding the part at a moulding temperature greater than the melting temperature of the superalloy, and cooling the part, such that the monocrystalline superalloy has a ? phase and a ? phase, solution heat treatment of the part at a first temperature between the solves temperature of the ?? phase and the melting temperature of the superalloy, homogenising the crystalline structure or the part, cooling the part to ambient temperature, first tempering and second tempering.
    Type: Application
    Filed: June 26, 2020
    Publication date: August 4, 2022
    Applicants: Safran Aircraft Engines, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NATIONALE SUPERIEURE DE MECANIQUE ET D'AEROTECHNIQUE DE POITIERS, UNIVERSITE DE POITIERS
    Inventors: Satoshi UTADA, Joël DELAUTRE, Sarah HAMADI, Jonathan CORMIER, Patrick VILLECHAISE, Jérémy RAME
  • METHOD FOR PREPARING A MONOLITHIC NANOPOROUS SILICATE SOL-GEL MATERIAL
    Publication number: 20220242739
    Abstract: A method for preparing a monolithic nanoporous silicate sol-gel material for modulating the pore size distribution for one single starting composition without the addition of a structuring agent. The method includes the following steps: a) synthesising a gel from at least one organosilylated precursor, the synthesis being carried out in an aqueous medium, optionally including an organic solvent and without a structuring agent, and b) drying the gel obtained in step a) at a temperature between 10° C. and 70° C., preferably between 15° C. and 55° C. and more preferably between 20° C. and 40° C., in a gas flow in a drying chamber to obtain a monolithic nanoporous silicate sol-gel material and a residual relative humidity in the drying chamber of between 0.1 and 20%, preferably between 0.5 and 10% and more preferably about 5%.
    Type: Application
    Filed: October 4, 2019
    Publication date: August 4, 2022
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, ECOLE NATIONALE SUPERIEURE MINES-TELECOM LILLE-DOUAI
    Inventors: Clarisse TRAN, Thu-Hoa TRAN-THI, Sabine CRUNAIRE, Jean-Luc WOJKIEWICZ