Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.

Abstract: Disclosed is a device for the perfusion of an organ, including: a container of fluid, containing an organ bathed in the perfusion fluid; a first path including an inlet, an outlet and a pump; and a second path including an inlet, an outlet and a pump. The “arterial” outlet of the first path has a diameter smaller than a diameter of the “portal” outlet of the second path. The device additionally includes, between the pump and the outlet of the first path and/or between the pump and the outlet of the second path, an oxygenation unit arranged to oxygenate the fluid emerging from the “arterial” outlet of the first path more than the fluid emerging from the “portal” outlet of the second path. The device can include a communication path between the first path and the second path in order to oxygenate the second path. Use in liver transplantation.

Abstract: The present invention relates the field of reducing CD95-mediated cell motility in a subject, in particular for their use in the reduction of CD-95 mediated cancer cell motility, the reduction of CD95-mediated lymphocyte motility and/or B cell maturation, or the treatment of B-cell tumors, in a subject. The inventors identified a novel family of compounds having the ability to disrupt CD95/PLC?1 interaction and to neutralize the CD95-mediated calcium signaling pathway and cell migration in human peripheral blood lymphocytes (PBLs) and Th17 cells.

Abstract: The invention relates to antibodies, which bind a peptide having a sequence selected from SEQ ID NO: 2, or a fragment or derivative of such an antibody having essentially the same antigen specificity. In particular, the antibodies suited to be used to detect, manage or monitor cancer in a subject, particularly cancer with interleukin-4 induced gene 1 (IL4I1) expressing cells. The invention also relates to kits or devices containing said antibodies, suitable for immunologic detection or reaction from any biological sample.

Abstract: The present invention relates to new peptides comprising an amino acid sequence LL-[X]n-LL, wherein X is selected from R, L and W, and n=10 to 12, and wherein [X]n comprises 4 R, 4 L and between 2 and 4 W, that may be used as cell-penetrating peptides. The present invention also relates to nanoparticles comprising a peptide of the invention and a cargo molecule and uses thereof.

Abstract: The invention concerns a system for controlling the temperature of a microfluidic chip comprising a Peltier module (10) having a cold face (10a) and a hot face (10b) and connected to a power generator (11), a thermal regulation device (12) having a thermal regulated face (12a) applied against one of the faces of the Peltier module, at least one temperature sensor (17) being applied on the other face of the Peltier module and being intended to be applied against one of the main faces of a microfluidic chip and control means (18) configured to control the power generator (11) of the Peltier module depending on a temperature of the face of the Peltier module provided with said at least one temperature sensor and at least one temperature setting information selected from a target temperature and a target temporal temperature profile to regulate a temperature of the face of the Peltier module to said temperature setting information.

Abstract: The present invention relates to a polypeptide X1X2-RK-X3X4-KK-X5X6X7X8X9X10-KR-X11X12 SEQ ID NO: 1 able to bind selectively to cells expressing proteoglycans comprising glycosaminoglycans as heparin or heparan sulfate. The linkage of said polypeptide to an internalization peptide enables the polypeptide to be internalized. The present invention further relates to a conjugated polypeptide comprising said polypeptide and a biomarker, to a cell penetrating polypeptide comprising said polypeptide, optionally a linker and a cell internalization peptide and a chimeric polypeptide comprising said cell penetrating polypeptide and one or more biological cargos.

Abstract: Method for processing a plurality of X-ray tomography volume images each associated with a part, the plurality of volume images comprising a reference volume image, including: a step of correlating volume images to obtain a displacement field between each image and the reference image, to obtain a plurality of displacement fields minimizing the difference between the volume images, a processing by a dimensionality reduction method of the plurality of the image displacement fields to express them according to eigenmodes, and a statistical analysis of the fields expressed according to the eigenmodes.

Abstract: A nanoporous carbon-loaded cement composite that conducts electricity. The nanoporous carbon-loaded cement composite can be used in a variety of different fields of use, including, for example, a structural super-capacitor as an energy solution for autonomous housing and other buildings, a heated cement for pavement deicing or house basement insulation against capillary rise, a protection of concrete against freeze-thaw (FT) or alkali silica reaction (ASR) or other crystallization degradation processes, and as a conductive cable, wire or concrete trace.

Abstract: A comb copolymer A2 including at least two boronic ester functions, the copolymer including a main chain and side chains, and at least one portion of the side chains of the copolymer A2 made of oligomers. Also, a composition resulting from mixing at least one polydiol compound A1 and a copolymer A2. The compositions exhibit very varied rheological properties depending on the proportion of the compounds A1 and A2 used. Also, a lubricant composition including such a mixture and at least one lubricating oil. Also, use of this composition to lubricate a mechanical part.

Abstract: A method for the selective cleavage of a compound comprising an aromatic ring and a C—O—C linkage in the presence of a heterogeneous catalyst is provided. The heterogenous catalyst may be a supported noble metal catalyst doped with a halogen selected from the group consisting of chlorine and bromine. By using this method, it is possible to increase the selectivity and/or yield (preferably both) of aromatic compounds.

Abstract: A method for producing a vertical component comprising with the basis of a III-N material, comprising providing platelets made of the III-N material obtained by epitaxy on pads, the platelets comprise at least first and second layers doped and stacked on one another in a vertical direction. The method further includes the production of a first electrode and the production of a second electrode located on the platelet and configured such that a current passing from one electrode to the other passes through at least the second layer in all of its thickness, the thickness being taken in the vertical direction.

Abstract: A telecommunication cable including a core with a plurality of optical fibres, an inner reinforcement radially arranged around the core, the inner reinforcement having a plurality of steel wires, an intermediate sheath arranged radially between the core and the inner reinforcement, and a protective sheath made of polymer material arranged radially around the inner reinforcement. The cable further includes at least one optical fibre sensor arranged between the core and the protective sheath.

Abstract: A polymer of hyaluronic acid modified by the grafting thereto of at least one of the functions —SO3? and aromatic rings may be used as dopant for a polymer formed from one or monomers chosen from EDOT, ProDOT, and derivatives thereof. An aqueous suspension, or ink, and materials, in particular hydrogels, based on at least one PEDOT and/or PProDOT polymer may be doped by at least one such modified hyaluronic acid polymer. Such modified hyaluronic acid polymers may be used in bioelectronic or biosensor devices.

Abstract: A device tracking system for monitoring a target body structure and localizing a device inside the target body structure. The device tracking system includes: a control unit, a device having one steering element to be handled outside the target body structure and one steerable element to be introduced inside the target body structure, one probe to be removably secured to the patient, and one tracker to be secured to the steerable element. The control unit stores one ultrasound image of the target body structure. The probe and the tracker communicate, and the control unit is able to localize, in real time, the steerable element. The control unit displays, the stored ultrasound image and displays, in real time, the localisation of the at steerable element on the at least one ultrasound image.

Abstract: The disclosure relates to a method for characterizing biological particles in aerosol form, such as suspended in an ambient gas, by laser-induced breakdown spectrometry and an associated system.

Abstract: A method for preparing an organic/inorganic hybrid composition including mineral nanoparticles functionalized by at least one molecule chosen from colored charged organic molecules, this method including providing a solution (a) of at least one colored charged organic molecule, providing a suspension (b) of non-swelling phyllosilicate nanoparticles, contacting the solution (a) and the suspension (b), the non-swelling phyllosilicate nanoparticles having a thickness of 1 nm to 100 nm, and a larger dimension of 10 nm to 10 ?m. A composition of organic/inorganic hybrid colored nanoparticles obtained by this method is also disclosed.

Abstract: A device for determining a measurand, includes a first pattern made from a first conductive material, the first pattern having a first impedance and having a first end and a second end spaced apart from the first end, a second pattern at least arranged between the first end and the second end of the first pattern, being in electrical contact with the first pattern. The second pattern has a second impedance that changes continuously as a function of the measurand, such that the impedance or the inductance of the assembly formed by the first and second patterns changes continuously as a function of the measurand. The device also comprises a means for determining the impedance or the inductance of the assembly, formed by the first and second patterns.

Abstract: A surface acoustic wave device includes at least one transducer; two acoustic reflectors disposed on either side of the at least one transducer so as to form a cavity, each acoustic reflector comprising an array of electrodes in the form of lines parallel with each other, each array comprising a subset of electrodes connected to a reference potential denoted mass defining a first connection type, and a subset of electrodes that are not connected to any potential, i.e. that have a floating connection defining a second connection type; at least one switching circuit configured to modify the distribution of the connections of at least one part of the electrodes of each array between the different connection types.

Abstract: The present invention relates to antibodies having specificity to Nectin-4 and uses thereof.