Abstract: The invention relates to the use of an uridine derivative of formula (I); wherein —R1 represents monohalogenated alkynyl or dihalogenated alkenyl; —R2 is chosen from among hydrogen, hydroxyl, O-alkyl, O—CO alkyl and halogen; —R3 is chosen from among hydrogen, hydroxyl, O-alkyl, O—CO alkyl, halogen, SH, S-alkyl and N3; and —R4 is chosen from among hydroxyl, O-alkyl, O—CO alkyl, O-phosphate, O-diphosphate, O-triphosphate and O phosphonate, as well as its possible tautomers, its possible pharmaceutically acceptable addition salts with an acid or a base, and its N-oxide forms, for the preparation of a drug having antiviral activity against a Flaviviridae.
Type:
Application
Filed:
December 22, 2005
Publication date:
January 1, 2009
Applicants:
Institute National De La Sainte Et De La Rechderche Medicale, Centre National De La Recherche Sceintifique
Inventors:
Vincent Aucagne, Vanessa Escuret, Fabien Zoulim, David Durantel, Christian Trepo, Luigi Agrofoglio, Nicolas Joubert, Franck Amelard
Abstract: This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active 2?-deoxy-?-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof, wherein the 2?-deoxy-?-L-erythro-pentofuranonucleoside has the formula: wherein R is selected from the group consisting of H, straight chained, branched or cyclic alkyl, CO-alkyl, CO-aryl, CO-alkoxyalkyl, CO-aryloxyalkyl, CO-substituted aryl, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, amino acid residue, mono, di, or triphosphate, or a phosphate derivative; and BASE is a purine or pyrimidine base which may be optionally substituted. The 2?-deoxy-?-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof may be administered either alone or in combination with another 2?-deoxy-?-L-erythro-pentofuranonucleoside or in combination with another anti-hepatitis B agent.
Type:
Application
Filed:
November 9, 2006
Publication date:
April 19, 2007
Applicants:
Idenix Pharmaceuticals, Inc., Centre National de La Recherche Sceintifique, L'Universite Montpellier II
Inventors:
Gilles Gosselin, Jean-Louis Imbach, Martin Bryant
Abstract: A quantitative magneto-optical imaging method is used to form an image of a target material. An active material is placed close to the target material and produces a Faraday rotation in a polarized light beam. The Faraday rotation of the active material is essentially proportional to the magnetization of the target material when this latter is subjected to an exciting magnetic field. Photodetector means detect the beam reflected after passing through the active material. The light from the reflected beam can then be analyzed for obtaining the amplitude and phase of an interfering magnetic field generated by a defect in the target material.
Type:
Application
Filed:
June 24, 2004
Publication date:
July 6, 2006
Applicant:
Centre National De La Recherche Sceintifique (CNRS)
Inventors:
Jean-Marc Decitre, Michel Lemistre, Jamal Ben Youssef, Francois Lepoutre, Dominique Placko, Pierre-Yves Joubert