Abstract: The invention relates to a genetically modified infectious measles virus derived from a live-attenuated measles virus strain, in which the gene encoding the viral accessory C protein has been knocked out (MV-deltaC). It concerns in particular the use of said genetically modified infectious MV-deltaC in the treatment of malignant tumor or cancer conditions, and for the preparation of agents or compositions for such treatment.
Type:
Grant
Filed:
January 25, 2018
Date of Patent:
June 11, 2019
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), INSTITUT PASTEUR, UNIVERSITE DE NANTES
Abstract: The invention relates to a genetically modified infectious measles virus derived from a live-attenuated measles virus strain, in which the gene encoding the viral accessory C protein has been knocked out (MV-deltaC). It concerns in particular the use of said genetically modified infectious MV-deltaC in the treatment of malignant tumor or cancer conditions, and for the preparation of agents or compositions for such treatment.
Type:
Grant
Filed:
January 20, 2014
Date of Patent:
February 13, 2018
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCENTIFIQUE (CNRS), INSITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), INSTITUT PASTEUR, UNIVERSITE DE NANTES
Abstract: A method for immobilizing biological polymers such as DNA or proteins, on a solid support, by ionocovalent bond, for making biochips, and the resulting chips obtained by the method. Also, a kit for the preparation of the chips.
Type:
Grant
Filed:
July 15, 2010
Date of Patent:
February 23, 2016
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCENTIFIQUE (C.N.R.S), UNIVERSITE DE NANTES, UNIVERSITY OF FLORIDA
Inventors:
Charles Tellier, Muriel Pipelier, Didier Dubreuil, Bruno Bujoli, Daniel Talham
Abstract: The present invention pertains to novel enaminoketones containing a CF3O-group, novel pyrazole-derivatives containing a CF3O group as well as to a novel process for their preparation comprising aminoformylation of CF3O-ketones and cyclization of the obtained CF3O-enaminoketones with hydrazines to trifluoromethoxy pyrazoles.
Type:
Application
Filed:
February 13, 2013
Publication date:
January 15, 2015
Applicants:
BAYER INTELLECTUAL PROPERTY GMBH, CENTRE NATIONAL DE LA RECHERCHE SCENTIFIQUE
Abstract: The disclosure relates to an amplifier comprising a digital delta-sigma modulator, a quantifier receiving a signal supplied by a delta-sigma stage and supplying a quantified signal, and a power circuit supplying an output signal. The device comprises N state loops of a first type configured to send the output signal to adders of N delta-sigma stages of lower rank, each state loop of the first type comprising an analog low-pass filter for supplying a filtered output signal, and an analog to digital converter for supplying a digital filtered output signal.
Type:
Grant
Filed:
December 15, 2010
Date of Patent:
July 24, 2012
Assignees:
Universite de Provence Aix-Marseillei, Centre National de la Recherche Scentifique, Primachip SAS
Abstract: In order to carry out a selective extraction of cations (Mn+) by an electrochemical transfer in a solution from a first electrolyte (E1) to a second electrolyte (E2), the method includes using as an electrolyte separation wall a transfer wall (2) made of chalcogenide with molybdenum clusters (MonXn+2 or MxMonXn+2) and ensuring the cation transfer through the transfer wall by generating a potential difference (?E) between the electrode A1 in the first electrolyte (E1) and the electrode C2 in the second electrolyte (E1) or the transfer wall (2) in order to induce an interleaving of the cations in the transfer wall on the side of the first electrolyte, a scattering of the cations therein, and the de-interleaving thereof in the second electrolyte.
Type:
Application
Filed:
June 25, 2008
Publication date:
October 7, 2010
Applicants:
UNIVERSITE PAUL VERLAINE, CENTRE NATIONAL DE LA RECHERCHE SCENTIFIQUE
Abstract: A device formed of a sampling “plate” includes an assembly of elements for individual storage samples regularly arranged in a line x column matrix, each of the storage elements may be accessed for placing or taking a sample, a lid may be installed on the plate in order to isolate the storage elements from the environment. The lid includes movable access elements enabling, in a first opening position, to access at least one of the storage elements and, in a second closing position, to isolate the at least one of the storage elements from the environment in order to enable, in the first opening position, access to the one storage elements the lid being arranged on the plate and including one fixed part and at least one mobile part. The mobile part is a disk mobile in rotation or a plate in translation.
Type:
Application
Filed:
March 26, 2003
Publication date:
May 19, 2005
Applicant:
Centre National De La Recherche Scentifique-CNRS