Abstract: The invention relates to a genetically modified infectious measles virus derived from a live-attenuated measles virus strain, in which the gene encoding the viral accessory C protein has been knocked out (MV-deltaC). It concerns in particular the use of said genetically modified infectious MV-deltaC in the treatment of malignant tumor or cancer conditions, and for the preparation of agents or compositions for such treatment.
Type:
Grant
Filed:
January 25, 2018
Date of Patent:
June 11, 2019
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), INSTITUT PASTEUR, UNIVERSITE DE NANTES
Abstract: The invention relates to a genetically modified infectious measles virus derived from a live-attenuated measles virus strain, in which the gene encoding the viral accessory C protein has been knocked out (MV-deltaC). It concerns in particular the use of said genetically modified infectious MV-deltaC in the treatment of malignant tumor or cancer conditions, and for the preparation of agents or compositions for such treatment.
Type:
Grant
Filed:
January 20, 2014
Date of Patent:
February 13, 2018
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCENTIFIQUE (CNRS), INSITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), INSTITUT PASTEUR, UNIVERSITE DE NANTES
Abstract: A device formed of a sampling “plate” includes an assembly of elements for individual storage samples regularly arranged in a line x column matrix, each of the storage elements may be accessed for placing or taking a sample, a lid may be installed on the plate in order to isolate the storage elements from the environment. The lid includes movable access elements enabling, in a first opening position, to access at least one of the storage elements and, in a second closing position, to isolate the at least one of the storage elements from the environment in order to enable, in the first opening position, access to the one storage elements the lid being arranged on the plate and including one fixed part and at least one mobile part. The mobile part is a disk mobile in rotation or a plate in translation.
Type:
Application
Filed:
March 26, 2003
Publication date:
May 19, 2005
Applicant:
Centre National De La Recherche Scentifique-CNRS