Abstract: The present invention is concerned among others with compounds of formula (1), the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein Q is halo, C1-6 alkyl or C2-6 alkenyl; X is (a-2) with q and r being O and Z being O, S or SO; R1 is aryl; R2 is selected from formyl; C1-6alkyloxycarbonylalkyl; Het2; Het2C1-6alkyl, C1-6alkylthio; C1-6alkyl optionally substituted with one or two substituents each independently selected from hydroxy, and halo; R3 is selected from formyl; C1-6alkyl optionally substituted with one or two C1-6alkyloxy; R4 is hydrogen, with HTV inhibiting properties
Type:
Grant
Filed:
September 18, 2001
Date of Patent:
October 3, 2006
Assignees:
Centre National de la Recherche Schentifique, Institute Curie
Inventors:
Jérôme Guillemont, Abdellah Benjahad, Dominique Mabire, Chi Hung N'Guyen, David Grierson, Claude Monneret, Emile Bisagni, Gérard Sanz, Laurence Decrane