Patents Assigned to Centre National de la Recherche Scientfique
  • Patent number: 11214655
    Abstract: A new hydrogel made of crosslinked glycosaminoglycans, particularly crosslinked hyaluronic acid, chondroitin or chondroitin sulfate, having reversible linkages using boronic acid or boroxole derivatives leading to new benefits. Glycosaminoglycans that are crosslinked via an alkoxyboronate ester anion formed between a diol portion of a diol-functional moiety grafted to a first glycosaminoglycan and a boronate hemiester grafted to a second glycosaminoglycan.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: January 4, 2022
    Assignees: GALDERMA RESEARCH & DEVELOPMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTFIQUE
    Inventors: Rachel Auzely-Velty, Tamiris Figueiredo, Laura Jing Jing, Craig Steven Harris, Jean-Guy Boiteau, Thibaut Gerfaud, Loic Tomas
  • Publication number: 20180115014
    Abstract: A porous electrolyte membrane including a first main surface and a second main surface that are separated by a thickness, where carbon nanotubes, defining through-pores or through-channels that are open at their two ends, have a diameter smaller than or equal to 100 nm, are oriented in the direction of the thickness of the membrane, and are all substantially parallel over the entire thickness of the membrane, connect the first main surface and the second main surface; the carbon nanotubes are separated by a space, and the space between the carbon nanotubes is completely filled with at least one solid material, and an electrolyte is confined inside the carbon nanotubes. A method for preparing the membrane and an electrochemical device, such as a lithium accumulator or battery, including the electrolyte membrane.
    Type: Application
    Filed: March 25, 2016
    Publication date: April 26, 2018
    Applicants: Commissariat à l'énergie atomique et aux alternatives, Centre national de la recherche scientfique
    Inventors: Jean-Marc ZANOTTI, Quentin BERROD, Jean DIJON, Filippo FERDEGHINI, Patrick JUDEINSTEIN
  • Patent number: 9582325
    Abstract: A method for scheduling tasks with deadline constraints, based on a model of independent periodic tasks and carried out in the user space by means of API POSIX is provided.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: February 28, 2017
    Assignee: Centre National De La Recherche Scientfique
    Inventors: Sébastien Bilavarn, Muhammad Khurram Bhatti, Cécile Belleudy
  • Publication number: 20150243290
    Abstract: The invention relates to a method and the associated device 1 for separating one or more particular digital audio source signals (si) contained in a mixed multichannel digital audio signal (smix) obtained by mixing a plurality of digital audio source signals (s1, . . . , sp). According to the invention: the modulus of the amplitude or the normalized power of the particular source signal(s) (si) is determined from representative values of said particular source signal(s) contained in the mixed signal; and then linearly constrained minimum variance spatial filtering is performed on the mixed signal in order to obtain each particular source signal (s?i), said filtering being based on the distribution of said particular source signal between at least two channels of the mixed signal, and the modulus of the amplitude or the normalized power of said particular source signal is used as a linear constraint of the filter.
    Type: Application
    Filed: September 25, 2013
    Publication date: August 27, 2015
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTFIQUE (CNRS)
    Inventors: Sylvain Marchand, Stanislaw Gorlow
  • Publication number: 20140326700
    Abstract: The invention concerns a method of forming a graphene layer involving: heating a support layer in a reaction chamber; and forming the graphene layer on a surface of the support layer by: a) during a first time period, introducing into the reaction chamber an organic compound gas to cause a formation of carbon atoms on the surface; b) during a second time period after the first time period, reducing a rate of introduction of the organic compound gas into the reaction chamber and introducing into the reaction chamber a further gas, wherein the further gas is a carbon etching gas; and repeating a) and b) one or more times.
    Type: Application
    Filed: May 6, 2013
    Publication date: November 6, 2014
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTFIQUE
    Inventors: Vincent BOUCHIAT, Johann CORAUX, Zheng HAN
  • Publication number: 20140234887
    Abstract: The invention relates to novel peptidase substrates of formula (I): wherein R0, R1, R2, R3, R4, R5 and n are as defined in claim 1, and a method for detecting the presence of a catalytically active peptidase, by means of one of these substrates.
    Type: Application
    Filed: September 27, 2012
    Publication date: August 21, 2014
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTFIQUE
    Inventors: Jens Hasserodt, Oliver Thorn-Seshold
  • Patent number: 8742789
    Abstract: An interconnected array of reconfigurable logic cells which carry out at least one logic function, externally connected to peripheral connection network equipped with switch boxes and connected to programmable input/output blocks. The logic cells are distributed in a first dimension in rows i with i=1 to d and a second dimension in columns j with j=1 to w, with d?2 and w=2 or d=2 and w?2, each logic cell including a second input, a second input, a first output and a second output, the first input of each logic cell and the first output of each logic cell being connected to the connection network, the second input and the second output of each logic cell being connected to other different column and row logic cells except for the first and last rows or columns for d>2 or w>2 respectively.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: June 3, 2014
    Assignees: Ecole Centrale de Lyon, Universite Claude Bernard, Centre National de la Recherche Scientfique, Institut National des Sciences Appliquees de Lyon
    Inventors: Ian O'Connor, Nataliya Yakimets
  • Patent number: 8609732
    Abstract: The present invention relates to the use of compounds of general formula (I) and (II) for the preparation of a drug for preventing and/or treating disorders caused by Shiga toxins and related toxins.
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: December 17, 2013
    Assignees: Commissariat a l'Energie Atomique et aux Energies Alternatives, Institut Curie, Centre National de la Recherche Scientfique
    Inventors: Daniel Gillet, Julien Barbier, Ludger Johannes, Bahne Stechmann, Siau-Kun Bai
  • Publication number: 20110229485
    Abstract: The subject matter of the present disclosure relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compounds to interact with neurotrophin 3 (NT-3 or NT3), to the extracellular domain, or TrkC receptor and/or to inhibit the dimerization of the intracellular domain of the TrkC receptor expressed in tumor cells, particularly in neuroblastoma. The disclosure also relates to a method for predicting the presence of metastatic cancer or a bad prognosis cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of neurotrophin 3. The disclosure further comprises kits and compounds as a medicament for the treatment of neuroblastoma or cancer overexpressing neurotrophin 3 by the tumor cells.
    Type: Application
    Filed: May 22, 2009
    Publication date: September 22, 2011
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTFIQUE (CNRS), CENTRE LEON BERARD, ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Patrick Etienne Roger Mehlen, Servane Marie-séverine Tauszig-Delamasure, Céline Jacqueline-Andrée Delloye, Jimena Bouzas-Rodriguez
  • Publication number: 20110034253
    Abstract: The appliance designed to allow a living being to perceive sensations of virtual movements of part of his body comprises a control unit in which is stored a table containing a first plurality of basic excitation signals, a second plurality of macro-motifs each formed by a third plurality proper of the basic signals, a sequencer reading the macro-motifs in order to emit a second plurality of corresponding commands for excitation, each time, of a third plurality proper of vibrators selected from among a first plurality of vibrators carried by a coupling support in predetermined respective zones of the part of the body, the excitation of the third plurality proper of vibrators by the second plurality of commands being intended to mechanically stimulate elements of the body, to provoke the creation of bioelectrical signals in the living being, allowing him to perceive sensations of a given virtual movement.
    Type: Application
    Filed: April 22, 2009
    Publication date: February 10, 2011
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTFIQUE, UNIVERSITE DE PROVENCE
    Inventor: Jean-Pierre Roll
  • Publication number: 20100087644
    Abstract: The invention relates to all compounds of the formula (I) or (II) in which: L is a neutral ligand; X, X? are anionic ligands; R1 and R2 are, separately, a hydrogen, a C1-C6 alkyl, a C1-C6 perhalogenoalkyl, a aldehyde, a ketone, an ester, a nitrile, an aryl, a pyridinium alkyl, an optionally substituted C5 or C6 pyridinium alkyl, perhalogenoalkyl or cyclohexyl, a Cnh2NY radical 10 with n between 1 and 6 and y an i8onic marker, or a radical having the formula: wherein R1 can be a radical of formula (Ibis) when the compound has formula (I) or of formula (IIbis) when the compound has formula (II), R3 is a C1-C6 alkyl, or a C5 or C6 cycloalkyl or a C5 or C6 aryl; R0, R4, R5, R6, R7, R8, R9, R10, R11, are, separately, a hydrogen, C1-C6 alkyl, a C1-C6 perhalogenoalkyl, or a C5 or C6 aryl; wherein R9, R10, R11 can be a heterocycle; X1 is anion. R1 and R2 can form, with the N and the C to which they are attached, a heterocycle.
    Type: Application
    Filed: November 30, 2007
    Publication date: April 8, 2010
    Applicants: ECOLE NATIONALE SUPERIEURE DE CHIMIE DE RENNES, CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTFIQUE)
    Inventors: Marc Mauduit, Isabelle Laurent, Hervé Clavier
  • Publication number: 20090081646
    Abstract: The invention relates to polynucleotides and primers flanking a variable region of the intron of the chloroplast gene trnL of plant materials for detecting and identifying plant species. The invention also relates to methods for detecting and identifying plant species in complex or degraded mixtures.
    Type: Application
    Filed: October 6, 2005
    Publication date: March 26, 2009
    Applicants: UNIVERSITE JOSEPH FOURIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTFIQUE
    Inventors: Pierre Taberlet, Ludovic Gielly, Christian Philippe Miquel
  • Patent number: 7235532
    Abstract: The present invention relates to the use of a compound of formula I: in which, A1 is the radical corresponding to D- or L-Ser, A2 is the radical corresponding to D- or L-Asp or Glu, A3 is the radical corresponding to D- or L-Lys, Arg or Gm, A4 is the radical corresponding to D- or L-Pro, R1 and R2 are chosen, independently, from H, C1–C12-alkyl which may or may not be substituted, C7–C20-arylalkyl which may or may not be substituted, R4CO or R4COO, R4 being C1–C12-alkyl which may or may not be substituted, or C7–C20-arylalkyl which may or may not be substituted; among the substitutions, mention should be made of OH, NH2 or COOH, X1 and X2 are peptide or pseudopeptide bonds, X3 is CO or CH2 and R3 is OH, NH2, C1–C1-alkoxy or NH-X4-CH2-Z, X4 is a normal or branched C1–C12 hydrocarbon, and Z is H, OH, CO2H or CONH2, or the corresponding tripeptides comprising the radicals A1, A2, A3, and also the pharmacautically acceptable salts, for the preparation of a medicament for treating pathologies which may benef
    Type: Grant
    Filed: September 20, 2001
    Date of Patent: June 26, 2007
    Assignee: Centre National de la Recherche Scientfique
    Inventors: Joanna Bakala, Jean-Paul Pierre Potier, Françoise Lawrence, Nathalie Cheviron, Jérôme Bignon, Yves Fromes
  • Publication number: 20060101528
    Abstract: The invention relates to transgenic aquatic animals, particularly the clawed frog and the zebra fish and cells derived therefrom, characterised in comprising at least one expression cassette with a regulatory DNA sequence selected from the response elements to nuclear hormone receptors, particularly TRE, connected in a functional manner downstream of a DNA segment coding for a marker protein such as luciferase or GFP. The invention further relates to methods using the transgenic cells and animals according to the invention for the identification of endocrine disrupters in the environment.
    Type: Application
    Filed: May 27, 2003
    Publication date: May 11, 2006
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTFIQUE (CNRS)
    Inventors: Barbara Demeneix, Nathalie Turque