Patents Assigned to CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.
  • Patent number: 11814685
    Abstract: This invention relates to a method for diagnosing and/or prognosticating HER2-dependent cancer in a subject, comprising a) measuring the amount of one or more miRNA selected from the group consisting of miRNA 429-3p, miRNA 29c-3p, miRNA 29a-3p, miRNA 29b-3p, miRNA 200a-3p, miRNA 200b-3p, miRNA 200c-3p, miRNA 141-3p, miRNA 15a-5p, miRNA 15b-5p, miRNA 16-5p, miRNA 424-5p, miRNA 497-5p, miRNA 615-3p, miRNA 451a-3p and miRNA 542-5p in a sample from the subject; b) comparing the amount of one or more miRNA measured in step a) to a reference value; c) finding a deviation or no deviation of the amount of one or more miRNA measured in step a) from the reference value; and d) attributing said finding of deviation or no deviation to a particular diagnosis and/or prognosis of HER2-dependent cancer in the subject.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: November 14, 2023
    Assignees: UNIVERSITÉ PARIS CITÉ, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
    Inventors: Sandrine Bourdoulous, Anaïs Domingot, Camille Faure
  • Patent number: 11807762
    Abstract: There is a process for preparing in situ an aqueous gel ink with variable color having the following steps: (i) preparing a gel-based matrix of aqueous ink comprising a reducing agent, (ii) adding a solution of metallic salts, (iii) adding iron powder to obtain an aqueous gel ink with variable color, wherein the steps (ii) and (iii) can be interchanged. There also is an aqueous gel ink with variable color obtained according to the process of the disclosure, having a reducing agent, metallic nanoparticles and iron powder. There further is a writing instrument having an aqueous gel ink with variable color according to the disclosure.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: November 7, 2023
    Assignees: SOCIETE BIC, UNIVERSITE DE HAUTE ALSACE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
    Inventors: Karine Mougin, Feriel Ghellal, Arnaud Spangenberg, Romain Metillon, Olivier Albenge
  • Patent number: 11618827
    Abstract: A method for preparing a composition including mineral particles functionalized by at least one organic group and having a specific surface defined according to the BET method greater than 500 m2/g, involves: —choosing a phyllosilicate composition, including mineral particles having a thickness of less than 100 nm, a largest dimension of less than 10 ?m and belonging to the family of lamellar silicates; —choosing at least one functionalizing agent, from the group formed from the oxysilanes and oxygermanes having at least one organic group, —bringing the phyllosilicate composition into contact with a functionalizing solution including the functionalizing agent, so as to obtain a phyllosilicate composition including mineral particles functionalized by the organic group, while choosing the organic group from the group formed from the cationic heteroaryl groups, the quaternary ammonium groups and the salts of same. The phyllosilicate composition obtained by the method is also described.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: April 4, 2023
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE PAUL SABATIER TOULOUSE III
    Inventors: Christophe Le Roux, Francois Martin, Pierre Micoud, Angela Dumas
  • Patent number: 11399804
    Abstract: A method for characterizing an anisotropic soft medium (C) including fibers and having an outer surface (1), by observing in different propagation directions, the propagation of a divergent shear wave from a central area (10) in the anisotropic soft medium. A propagation parameter of the shear wave is inferred therefrom in each of the propagation directions, and then a direction of the fibers of the anisotropic soft medium, a rheological elasticity parameter are determined in a direction perpendicular to the fibers and a rheological elasticity parameter in the direction of the fibers.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: August 2, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ECOLE SUPRERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, UNIVERSITÉ PARIS DIDEROT—PARIS 7
    Inventors: Mickaël Tanter, Mathieu Pernot, Mathias Fink, Jean-Luc Gennisson
  • Publication number: 20220196538
    Abstract: A device for medical analyses with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer (6) arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier (8) arranged to retrieve from the computer (6) a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group (10) or a rotationless pulse data set group (12).
    Type: Application
    Filed: April 24, 2020
    Publication date: June 23, 2022
    Applicants: HORIBA ABX SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE DE MONTPELLIER
    Inventors: Pierre TARACONAT, Damien ISEBE, Simon MENDEZ, Franck NlCOUD
  • Patent number: 11352627
    Abstract: This invention relates to an agent that modulates the activity of a micro ribonucleic acid (miRNA), said miRNA being selected from the group consisting of miRNA 429-3p, miRNA 29c-3p, miRNA 29b-3p, miRNA 200a-3p, miRNA 200b-3p, miRNA 200c-3p, miRNA 141-3p, miRNA 15a-5p, miRNA 15b-5p, miRNA 16-5p, miRNA 424-5p, miRNA 497-5p, miRNA 615-3p, miRNA 451a-5p and miRNA 542-5p, for use in the treatment of HER2-dependent cancer.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: June 7, 2022
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
    Inventors: Sandrine Bourdoulous, Anaïs Domingot, Camille Faure
  • Patent number: 11340239
    Abstract: The present invention relates to a polypeptide carrying a human BNP(1-32) epitope according to Formula (I): a1-R1-X1-FGRKMDR-X2-R2-a2 as well as ligands specific of the FGRKMDR epitope.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: May 24, 2022
    Assignees: BIO-RAD EUROPE GMBH, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
    Inventors: Francois Rieunier, Isabelle Giuliani, Sylvie Villard-Saussine
  • Patent number: 11312863
    Abstract: A method for preparing a composition including mineral particles functionalized by at least one organic group and having a specific surface defined according to the BET method greater than 500 m2/g, involves: —choosing a phyllosilicate composition, including mineral particles having a thickness of less than 100 nm, a largest dimension of less than 10 ?m and belonging to the family of lamellar silicates; —choosing at least one functionalizing agent, from the group formed from the oxysilanes and oxygermanes having at least one organic group, —bringing the phyllosilicate composition into contact with a functionalizing solution including the functionalizing agent, so as to obtain a phyllosilicate composition including mineral particles functionalized by the organic group, while choosing the organic group from the group formed from the cationic heteroaryl groups, the quaternary ammonium groups and the salts of same. The phyllosilicate composition obtained by the method is also described.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: April 26, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE PAUL SABATIER TOULOUSE III
    Inventors: Christophe Le Roux, Francois Martin, Pierre Micoud, Angela Dumas
  • Patent number: 10946305
    Abstract: The invention relates to a method for producing a cocrystal of at least two compounds by means of instantaneous evaporation or flash evaporation, for example for the production of cocrystals in the fields of energetic materials, pharmaceutical compounds, phytopharmaceutical compounds, ferroelectric materials, non-linear response materials or bioelectronic materials.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: March 16, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE DE STRASBOURG, ISL-INSTITUT FRANCO-ALLEMAND DE RECHERCHES DE SAINT-LOUIS
    Inventors: Benedikt Risse, Denis Spitzer, Florent Pessina
  • Patent number: 10899019
    Abstract: A mechatronic device includes two arms extending from a base in a first direction and shaped to be handheld by an operator, the two arms having free ends forming a gripper and arranged to move closer together by rotation from a rest position to an active position, a motor housed in the base, an actuator mounted between the arms, and a means for controlling said actuator, the actuator connected to the motor so as to be driven in movement in translation in the first direction. The actuator also has a first contact surface that forms a cam with a respective second contact surface on each arm, the first contact surface remaining engaged with the second contact surface. The control means controls the movement in translation of the actuator to produce a movement in rotation of the arms that applies a chosen force of the gripper in its active position.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: January 26, 2021
    Assignees: PERCIPIO ROBOTICS, SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
    Inventors: Stephane Regnier, Thomas Daunizeau, Dogan Sinan Haliyo, Tianming Lu, Marie Lutringer, David Heriban
  • Patent number: 10881380
    Abstract: The present invention concerns a method for obtaining a functional parameter of a muscle having a part, the method comprising the steps of: a) applying ultrasound waves to the muscle, b) collecting the ultrasound waves retrodiffused by the muscle at a plurality of times, to obtain collected ultrasound waves, c) determining a first plurality of values representative of stiffness values of one part at a first plurality of times by using the collected ultrasound waves, d) determining a second plurality of values representative of deformation values of said part at a second plurality of times by using the collected ultrasound waves, and e) deducing at least one functional parameter based on the first plurality of values and the second plurality of values. The invention also concerns a corresponding device.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: January 5, 2021
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE PARIS DIDEROT—PARIS 7, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Mickael Tanter, Mathieu Pernot
  • Patent number: 10772930
    Abstract: The present invention relates to an isolated bacterium from the genus Pseudoalteromonas for its use as a probiotic, the use of said strain as a preservative, cyclolipopeptides which may be obtained from this bacterium, a composition comprising at least such a cyclolipopeptide, as well as to their uses.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: September 15, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE DE RENNES 1, UNIVERSITE DE BRETAGNE OCCIDENTALE
    Inventors: Florie Desriac, Yannick Fleury, Patrick Le Chevalier, Delphine Destoumieux, Matthieu Simon
  • Patent number: 10723999
    Abstract: The present invention relates to a process for in vitro spermatogenesis from male germinal tissue comprising conducting maturation of testicular tissue comprising germ cells in a bioreactor which is made of a biomaterial and comprises at least one cavity wherein the germinal tissue is placed, and recovering elongated spermatids and/or spermatozoa.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: July 28, 2020
    Assignees: KALLISTEM, UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), ECOLE NORMALE SUPERIEURE DE LYON
    Inventors: Marie-Hélène Perrard, Philippe Durand, Laurent David
  • Patent number: 10722813
    Abstract: A method of preparing organic or inorganic nanoparticles is useful in the manufacture of of fertilizers, pharmaceutical or phytopharmaceutical active ingredients, or insensitive energy materials. The method includes preparing a solution of a compound in a solvent, heating the solution under a pressure ranging from 3 to 300 bars at a temperature higher than the boiling point of the solvent, atomizing the solution in an spray drying chamber using at least one dispersion device and at an angle ranging from 30 to 150° under pressure ranging from 0.0001 to 2 bars, separating the solvent in gaseous form, and recovering the nanoparticles.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: July 28, 2020
    Assignees: ISL—INSTITUT FRANCO-ALLEMAND DE RECHERCHES DE SAINT-LOUIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
    Inventors: Benedikt Risse, Dominique Hassler, Denis Spitzer
  • Patent number: 10711232
    Abstract: The invention relates to a bioreactor comprising a tank containing a culture medium in which a cell culture composed of algae cells is dispersed. The cell culture of algae has a concentration greater than 0.1 g/L in the culture medium, and each algal cell has a minimum absorption in a specific range of wavelengths of light. The bioreactor comprises a light source that is capable of emitting incident light in the direction of the tank, 60% of the photons of the incident light having a wavelength which is included in said specific range of wavelengths of light. The invention also relates to the use of the bioreactor for the production of biomass.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: July 14, 2020
    Assignees: Inria Institut National De Recherche En Informatique Et En Automatique, Centre National De La Recherche Scientifique (C.N.R.S.), Universite Pierre Et Marie Curie (Paris 6)
    Inventors: Francis Mairet, Olivier Bernard, Antoine Sciandra, Eric Pruvost, Charlotte Combe
  • Patent number: 10583222
    Abstract: The present invention concerns composite biomaterials comprising ceramic and a biodegradable polymer gel, with improved bioactivity, their process of preparation and their use for orthopedics, dentistry or reconstructive surgery, in particular for use as a bone filler.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: March 10, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITÉ PAUL SABATIER TOULOUSE III
    Inventor: Sophie Cazalbou
  • Patent number: 10577251
    Abstract: A composition comprising synthetic mineral particles, such as silicate or phyllosilicate mineral particles, is presented. The composition can be prepared by a process in which a hydrogel precursor of the synthetic mineral particles is produced by a coprecipitation reaction between at least one compound comprising silicon, such as sodium metasilicate, and at least one compound comprising at least one metal element, such as a dicarboxylate salt of the formula M(R1—COO)2, wherein R1 is H or an alkyl group having 1 to 4 carbon atoms. The coprecipitation reaction also takes place in the presence of at least one carboxylate salt of formula R2—COOM? wherein M? is Na or K, and R2 is H or an alkyl group having 1 to 4 carbon atoms.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: March 3, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE PAUL SABATIER (TOULOUSE III)
    Inventors: Christophe Le Roux, Francois Martin, Pierre Micoud, Angela Dumas
  • Patent number: 10556510
    Abstract: Provided are methods, systems and devices for thermodynamically evaluating electrochemical systems and components thereof, including electrochemical cells such as batteries. The present systems and methods are capable of monitoring selected electrochemical cell conditions, such as temperature, open circuit voltage and/or composition, and carrying out measurements of a number of cell parameters, including open circuit voltage, time and temperature, with accuracies large enough to allow for precise determination of thermodynamic state functions and materials properties relating to the composition, phase, states of charge, health and safety and electrochemical properties of electrodes and electrolytes in an electrochemical cell. Thermodynamic measurement systems of the present invention are highly versatile and provide information for predicting a wide range of performance attributes for virtually any electrochemical system having an electrode pair.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: February 11, 2020
    Assignees: California Institute of Technology, Centre National De La Recherche Scientifique (C.N.R.S.), Nanyang Technological University
    Inventor: Rachid Yazami
  • Patent number: 10495649
    Abstract: The present invention relates to a polypeptide carrying a human BNP(1-32) epitope according to Formula (I): a1-R1—X1—FGRKMDR—X2—R2-a2 as well as ligands specific of the FGRKMDR epitope.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: December 3, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), BIO-RAD EUROPE GMBH
    Inventors: Francois Rieunier, Isabelle Giuliani, Sylvie Villard-Saussine
  • Patent number: 10490347
    Abstract: A method for producing a monolithic electromagnetic component includes preparing a precursor from a ferrite material during an initial step; preparing elements including at least one coil having coil turns; embedding the elements including at least one coil having the coil turns in the precursor embedded in a mold; co-sintering the elements including at least one coil having the coil turns and the precursor compressed by the mold under a predetermined pressure, the predetermined pressure being generated under a load, wherein a pulsed electric current is generated during the co-sintering; discharging the pulsed electric current through the mold such that a temperature in the mold rises; and obtaining the monolithic electromagnetic component in which the precursor is secured to the elements including at least one coil having the coil turns.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: November 26, 2019
    Assignee: Centre National de la Recherche Scientifique (C.N.R.S.)
    Inventors: Frédéric Mazaleyrat, Karim Zehani, Vincent Loyau, Eric Laboure