Patents Assigned to Centre National de la Recherche Scientifique (CNR
  • Patent number: 12257103
    Abstract: Method for non-invasively characterizing a heterogeneous medium using ultrasound, comprising a step of generating a series of incident ultrasonic waves, a step of recording an experimental reflection matrix Rui(t) defined between the input emission basis (i) and an output reception basis (u), a step of determining a response REP(r,?r) of the medium between an input virtual transducer (TVin) calculated based on an input focusing of the experimental reflection matrix that creates an input focal spot around a first point (P1), and an output virtual transducer (TVout) calculated based on an output focusing of the experimental reflection matrix that creates an output focal spot around a second point (P2), said response being expressed as a function of a central point (PC) of spatial position (r) in the medium located midway between the first and second points (P1, P2).
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: March 25, 2025
    Assignees: SUPERSONIC IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris
    Inventors: William Lambert, Alexandre Aubry, Mathias Fink, Laura Cobus
  • Patent number: 12250944
    Abstract: The present invention relates to the long-term preservation of biological material. More specifically, it concerns a preservation container comprising: a biological container for containing biological material, a first shield configured for absorbing gamma-rays, a second shield configured for absorbing ambient neutrons, said second shield surrounding the biological container, the preservation container being of low-radioactivity background materials, and a method for preserving a biological material, comprising: a) providing a biological material in a confinement container, b) providing the preservation container of the invention, c) placing the confinement container containing the biological material into said preservation container, d) storing said preservation container containing the biological material in a room located under a material attenuating cosmic rays and induced particles, said material having a thickness equivalent to 1 m to 7000 m of water, for attenuating cosmic rays.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: March 18, 2025
    Assignees: Centre National de la Recherche Scientifique (CNRS), Institut Pasteur, Université Paris Cité, Groupe Hospitalier Universitaire Paris—Psychiatrie et Neurosciences
    Inventors: Maurice Chapellier, Fabrice Chretien, Fabrice Piquemal, Pierre Rocheteau, Guillaume Warot, Michel Zampaolo
  • Patent number: 12252514
    Abstract: The invention relates to the field of molecular biology and particularly novel genes that encode pesticidal proteins useful for controlling pests, particularly plant pests. These proteins and the nucleic acid sequences that encode them are useful in preparing pesticidal compositions and in the production of transgenic pest-resistant plants.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: March 18, 2025
    Assignees: GENECTIVE, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, PCAS, SEMAE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Carine Bonzom-Audiffrin, Wafa Achouak, Mohamed Barakat, Philippe Ortet, David Vallenet, Thierry Heulin, Christophe Sallaud, Mickael Bosio, Virginie Guyon, Wyatt Paul
  • Publication number: 20250081706
    Abstract: The invention refers to an electronic component, in particular an organic electrochemical transistor (OECT) which comprises at least one gate electrode, a source electrode, a drain electrode, a channel and an electrolyte. The electrolyte is a solid electrolyte comprising a polymer, and the channel comprises an organic semiconductor as channel material. The electrolyte has a low water content and/or a low C1-C3-alcohol content as well as a low maximum halogen alkaline salt or alkaline earth or acetate salt content. The invention further refers to the use of this electronic component as a Schmitt-Trigger or a Muller-C-element or a flip-flop or a 1-bit memory. Further, the invention provides a method for forming such an electronic component.
    Type: Application
    Filed: August 28, 2024
    Publication date: March 6, 2025
    Applicants: TECHNISCHE UNIVERSITÄT DRESDEN, UNIVERSITÉ PARIS-SACLAY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Hans KLEEMANN, Jann KRAUSSE, Lukas BONGARTZ, Karl LEO, Laurie CALVET, Zonglong LI
  • Patent number: 12241151
    Abstract: The invention concerns a method for manufacturing an aircraft part, the part comprising a monocrystalline nickel-based superalloy substrate, the method consecutively implementing the steps of moulding the part at a moulding temperature greater than the melting temperature of the superalloy, and cooling the part, such that the monocrystalline superalloy has a ? phase and a ? phase, solution heat treatment of the part at a first temperature between the solves temperature of the ?? phase and the melting temperature of the superalloy, homogenising the crystalline structure or the part, cooling the part to ambient temperature, first tempering and second tempering.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: March 4, 2025
    Assignees: SAFRAN AIRCRAFT ENGINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NATIONALE SUPERIEURE DE MECANIQUE ET D'AEROTECHNIQUE DE POITIERS, UNIVERSITE DE POITIERS
    Inventors: Satoshi Utada, Joël Delautre, Sarah Hamadi, Jonathan Cormier, Patrick Villechaise, Jérémy Rame
  • Patent number: 12232883
    Abstract: The method of modulating epileptogenicity in a brain of an epileptic patient includes: providing a virtual brain; providing a model of an epileptogenic and of a propagation zones and loading the models in the virtual brain to create a virtual epileptic brain; acquiring data of the brain of the epileptic patient; identifying, in the data, a location of at least one possible epileptogenic zone; fitting the virtual epileptic brain against the data acquired from the epileptic patient and parametrizing the at least one possible epileptogenic zone in the virtual epileptic brain as an epileptogenic zone; and simulating, within the virtual epileptic brain, the effect of a network modulation mimicking a clinical intervention of the brain of the patient.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: February 25, 2025
    Assignees: UNIVERSITE D'AIX MARSEILLE (AMU), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSISTANCE PUBLIQUE—HOPITAUX DE MARSEILLE (AP-HM), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Viktor Jirsa, Christophe Bernard, Fabrice Bartolomei, Maxime Guye
  • Publication number: 20250062342
    Abstract: A method for delithiating a lithium and transition metal nitride. The method involves mixing an oxidising agent with the lithium and transition metal nitride and recovering the material obtained. The transition metal may be Mn, Fe, Co, Ni, Cu, or a mixture thereof. The material obtained by the method may be used as a negative electrode material for a lithium-ion battery.
    Type: Application
    Filed: December 23, 2022
    Publication date: February 20, 2025
    Applicants: AMPERE S.A.S., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS EST CRETEIL VAL DE MARNE
    Inventors: Nicolas EMERY, Olivier NGUYEN, Jean-Pierre PEREIRA-RAMOS, Yanlong ZHOU
  • Patent number: 12227767
    Abstract: The present invention is in the field of oncology, and more particularly of cancer stem cells. It relates to a method for producing cancer stem cells based on overexpression of ?133p53? isoform, ?133p53? isoform, or both ?133p53? and ?133p53? isoforms; a method for predicting the risk that treatment with a chemotherapeutic anti-cancer agent induces cancer stem cells in a subject suffering from cancer from a cancer sample of said subject, based on detection of an increase in ?133p53? isoform, ?133p53? isoform, or both ?133p53? and ?133p53? isoforms following chemotherapeutic anti-cancer treatment; to therapeutic uses of a combination of chemotherapeutic anti-cancer agent and an agent reducing ?133p53? isoform, ?133p53? isoform, or both ?133p53? and ?133p53? isoforms expression; and also to screening methods for anti-cancer stem cells agents.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: February 18, 2025
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite de Montpellier
    Inventors: Pierre Roux, Nikola Arsic, Gilles Gadea, Philippe Fort, Fanny Tomas, Véronique Gire
  • Publication number: 20250040942
    Abstract: A medical device for penetrating an anatomic structure, e.g., a bone structure, including a processing unit programmed to execute one or more statistical algorithms, e.g., Bayesian-based perforation detection algorithms, with electrical conductivity measured during penetration of an anatomic structure as an input to detect a breach condition, e.g., a spinal canal perforation, based on the measured electrical conductivity. The medical device may include a drill bit having sensing capabilities coupled to the distal end of a robot arm via a power drill unit mounted on the robot arm. The power drill unit may cease transmission of rotary motion to the drill bit upon detection of the breach condition.
    Type: Application
    Filed: July 25, 2024
    Publication date: February 6, 2025
    Applicants: SpineGuard, Sorbonne Universite, Centre National De La Recherche Scientifique-CNRS, INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Lilyan LEBLANC, Brahim TAMADAZTE, Thibault CHANDANSON, Elie SAGHBINY
  • Patent number: 12213486
    Abstract: A process for preparing a biocidal, bactericidal and/or bacteriostatic material including the preparation of a polymer precursor solution that has (a) at least one monomer A having a porphyrin group and at least one radical polymerizable function, (b) at least one radical polymerizable monomer B, a photoinitiator, and (c) at least one of the monomers chosen from a monomer C having a quaternary amine and a radical polymerizable function; and/or a monomer D having copper and a radical polymerizable function. Also, the material obtainable by the process and its uses.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: February 4, 2025
    Assignees: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (CEA), CONSERVATOIRE NATIONAL DES ARTS ET METIERS (CNAM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Thomas Berthelot, Céline Goulard-Huet, Fanny Hauquier
  • Publication number: 20250034208
    Abstract: The present invention relates to novel peptides having the same motif LRIRX1TYX2, where X1 is selected from amino acids A or F; and X2 is selected from amino acids G or K. The present invention also relates to their use in the treatment of skin changes of various origins, to pharmaceutical and cosmetic compositions comprising them, and to a cosmetic method. More particularly, the treatment of said changes consists in reinforcing the dermal-epidermal junction, cell-matrix and/or cell-cell adhesion and cell migration in the epidermis, and in promoting the repair of the skin surface.
    Type: Application
    Filed: September 20, 2022
    Publication date: January 30, 2025
    Applicants: LABORATOIRES D'ANJOU, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITÉ CLAUDE BERNARD LYON 1
    Inventor: Patricia ROUSSELLE
  • Patent number: 12210076
    Abstract: The invention relates to a material for use as a pad in high field and/or very high field magnetic resonance imaging instrument, comprising at least one polar solvent having a melting point of 14° C. to 50° C., a dispersant and a dielectric charge. The invention relates also to a pad used in field of high field and/or very high field magnetic resonance imaging made of at least such a material.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: January 28, 2025
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, ECOLE CENTRALE DE MARSEILLE, UNIVERSITE D'AIX-MARSEILLE (AMU)
    Inventors: Abdeddaim Redha, Anne-Lise Adenot-Engelvin, Marc Dubois, Stefan Enoch, Nicolas Mallejac, Zo Raolison, Pierre Sabouroux, Alexandre Vignaud
  • Publication number: 20250019748
    Abstract: The invention relates to a method for attaching nucleic acids to a platinum electrode, comprising the following steps: —a step (S1) of attaching an ethylenediamine molecule to the electrode, step (S1) comprising electro-oxidation of a primary amine from the ethylenediamine molecule by cyclic voltammetry, —a step (S2) of attaching a sulfo SMCC molecule of 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester to the ethylenediamine molecule, —a step (S3) of attaching a nucleic acid to the sulfo SMCC molecule, the nucleic acid having been modified beforehand to comprise a thiol function, the electrode being in contact with an aqueous solution, i.e. with a solution in which the solvent is water, during steps (S1), (S2) and (S3).
    Type: Application
    Filed: November 30, 2022
    Publication date: January 16, 2025
    Applicants: UNIVERSITE PARIS-SACLAY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Jean GAMBY, Jeremy LE GALL, Djamila KECHKECHE, Claire POUJOULY
  • Patent number: 12195437
    Abstract: The invention relates to compound of formula (I): in particular flavonoid derivatives (quercetin and catechin derivatives), for use in the prevention and/or the treatment of a disease or disorder involving both carbonyl and oxidative stresses.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: January 14, 2025
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite De Montpellier, Ecole Nationale Superieure de Chimie, Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Céline Crauste, Espérance Moine, Philippe Brabet, Thierry Durand, Joseph Vercauteren
  • Patent number: 12193864
    Abstract: The invention relates to a method for determining at least one property of an object, the method comprising a step of: a) obtaining first data relative to the object by an ultrasound imaging technique imaging the object at a frame rate superior to 300 Hz, characterized in that the method further comprises a step of: b) obtaining second data relative to the object by imaging the object with at least one of a X-ray and a ?-ray, and c) determining the at least one property of the object based on the first data and the second data.
    Type: Grant
    Filed: June 7, 2023
    Date of Patent: January 14, 2025
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, SORBONNE UNIVERSITE, UNIVERSITÉ PARIS CITÉ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: Jean Provost, Anikitos Garofalakis, Mathieu Pernot, Mickaël Tanter, Bertrand Tavitian, Thomas Viel
  • Patent number: 12188052
    Abstract: Method for preparing, in an insect cell, a recombinant baculovirus comprising one or more transgene(s) each encoding a protein maturation enzyme and n transgenes each encoding a polypeptide of interest, by homologous recombination between a replication deficient baculovirus genome which comprises one or more transgene(s) each encoding a protein maturation enzyme and n transfer vectors each comprising one of the n transgenes each encoding a polypeptide of interest, n being an integer at least equal to 2.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: January 7, 2025
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
    Inventors: Martine Cerutti, Sylvie Juliant, Coralie Bernon
  • Publication number: 20250003980
    Abstract: Identification of at least one microorganism present in a sample based on the detection of peptides issued from the cleavage of ribosomal proteins of said microorganism, comprising lysis of microorganism(s) and cleavage of the proteins, obtaining a mixture of peptides, decomplexing the peptide mixture using a liquid separation device coupled with a mass spectrometer, nebulizing the liquid to produce an ion current, receiving the ion current from the ion source, executing on the ion current a series of filtering steps for detecting a transition, receiving data on the transitions, assigning the transitions associated with peptides into two or more contiguous groups, monitoring, and optionally generating a chromatogram or electropherogram, wherein the microorganism is identified according to the detection of said peptide(s).
    Type: Application
    Filed: July 15, 2022
    Publication date: January 2, 2025
    Applicants: Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Ecole Normale Superieure de Lyon, Hospices Civils de Lyon
    Inventors: Jérôme LEMOINE, Maud GREGSON, Julie GIL, Romain CARRIERE, François VANDENESCH
  • Publication number: 20250000428
    Abstract: A computer-implemented method for assisting a general anesthesia or a sedation of a subject, having receiving an electroencephalogram EEG signal of a subject, processing the EEG signal including ?-bands for defining for each instant of a plurality of instants, a part of the signal has in a time window having the instant, the part of the signal being related to the instant, determining for each instant, a distribution of a power of the part of the signal as a function of the frequency, determining for each instant a maximum power frequency as a frequency of maximum power in the distribution, the maximum power frequency being related to the instant, detecting a reference instant, so that the maximum power frequency as a function of time takes higher values before the reference instant than after, detecting in a time frame following the reference instant, an alpha instant corresponding to a first occurrence of a suppression of an ?-band, estimating a first parameter as the duration between the reference inst
    Type: Application
    Filed: July 26, 2022
    Publication date: January 2, 2025
    Applicants: PARIS SCIENCES ET LETTRES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, NATIONAL INSTITUTE OF HEALTH AND MEDICAL RESEARCH, ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS
    Inventors: David HOLCMAN, Matteo DORA, Christophe SUN
  • Publication number: 20250006915
    Abstract: A process for preparing a compound of formula (NaOH)x[Fe(OH)2]yFeS, may include: (a) mixing iron and sodium sulfide in equimolar amounts, in an NaOH aqueous solution; (b) heating the obtained mixture up to a temperature in a range of from 110 to 210° C. for a duration in a range of from 1 hour to 1 week; and (c) recovering the active material by filtering and drying in a neutral atmosphere.
    Type: Application
    Filed: September 21, 2022
    Publication date: January 2, 2025
    Applicants: AMPERE S.A.S., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Ecole Nationale Supérieure de Chimie de Paris
    Inventors: Philippe BARBOUX, Mohamed CHAKIR, Domitille GIAUME, Ine HAUGLAND-GOSLING, Caroline MIR
  • Patent number: 12181415
    Abstract: A method for identifying a microorganism to be identified, which includes the following steps: obtaining an Excitation-Emission EEM of the microorganism to be identified, analysing the main components of the EEM matrix using at least one reference EEMr matrix, projecting the result of the analysis onto a plane defined by two main components, and identifying the microorganism to be identified.
    Type: Grant
    Filed: November 27, 2020
    Date of Patent: December 31, 2024
    Assignees: UNIVERSITE DU MANS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS-, CENTRE HOSPITALIER UNIVERSITAIRE D'ANGERS, UNIVERSITE D'ANGERS
    Inventors: Jean-François Bardeau, Jean-Philippe Bouchara