Abstract: A method for identifying a motif or a combination of motifs having a Boolean state of predetermined mutations in a set of sequences including a) aligning a set of sequences of ordered motifs represented by a single-character code, b) comparing a reference sequence with the set of sequences aligned in step (a), c) identifying motifs not having mutated simultaneously or motifs having mutated simultaneously at least once on at least one sequence of the set and not having mutated on another sequence of the set.
Type:
Application
Filed:
February 18, 2010
Publication date:
July 22, 2010
Applicant:
Centre National de la Recherche Scientifique - CNRS, a corporation of France
Inventors:
Anne Vanet, Michaela Muller-Trutwin, Thomas Valere
Abstract: A purified protein comprising a mechanosensitive potassium channel activated by at least one polyunsaturated fatty acid and riluzole and the use of said channels in drug screening.
Type:
Application
Filed:
December 5, 2008
Publication date:
June 25, 2009
Applicant:
Centre National de la Recherche Scientifique-CNRS, corporation of France
Inventors:
Eric Honore, Michel Fink, Michel Lazdunski, Florian Lesage, Fabrice Duprat
Abstract: A double-strand oligonucleotide including two complementary oligonucleotide sequences forming a hybrid, each including at one of their 3? or 5? ends, one to five unpaired nucleotides forming single-strand ends extending beyond the hybrid, one of the oligonucleotide sequences being substantially complementary to a target sequence belonging to a DNA or RNA molecule to be specifically repressed, the target sequence belonging to a DNA or RNA molecule of a gene coding an angiogenic factor.
Type:
Application
Filed:
February 28, 2008
Publication date:
November 20, 2008
Applicant:
Centre National de la Recherche Scientifique - CNRS, a corporation of France
Inventors:
Annick Harel-Bellan, Slimane Ait-Si-Ali, Florence Cabon-Georget, Anne Chauchereau, Francois Dautry, Luis Martinez
Abstract: The present invention relates to the use of an inhibitor of histone deacetylase for preparing a drug for the treatment or prevention of a disease resulting from the deficiency of an adult gene in an individual by the re-expression of the homologous fetal gene. The invention concerns in particular the treatment of dystrophies such as Duchenne's dystrophy or Becker's dystrophy in which the defective adult gene is the dystrophin gene and the homologous fetal gene is the utrophin gene.
Type:
Application
Filed:
January 3, 2008
Publication date:
July 3, 2008
Applicant:
Centre National de la Recherche Scientifique- CNRS, a corporation of France
Inventors:
Sabine De La Porte, Maurice Israel, Vincent Voisin, Hafedh Haddad
Abstract: Methods for identifying a motif or a combination of motifs having a Boolean state of predetermined mutations in a set of sequences including a) aligning a set of sequences of ordered motifs represented by a single-character code, b) comparing a reference sequence with the set of sequences aligned in step (a), c) identifying motifs not having mutated simultaneously and/or motifs having mutated simultaneously at least once on at least one sequence of the set and not having mutated on another sequence of the set.
Type:
Application
Filed:
June 30, 2006
Publication date:
January 25, 2007
Applicant:
Centre National de la Recherche Scientifique - CNRS, a corporation of France
Inventors:
Anne Vanet, Michaela Muller-Trutwin, Thomas Valere, Sophie Brouillet, Emmanuelle Ollivier, Laurent Marsan
Abstract: A purified protein comprising a mechanosensitive potassium channel activated by at least one polyunsaturated fatty acid and riluzole and the use of said channels in drug screening.
Type:
Application
Filed:
September 12, 2005
Publication date:
February 2, 2006
Applicant:
Centre National de la Recherche Scientifique - CNRS, corporation of France
Inventors:
Eric Honore, Michel Fink, Michel Lazdunski, Florian Lesage, Fabrice Duprat
Abstract: A peptide comprising one or more intramolecular bonds corresponding to formula (I): Xaa-Ca1-Xab-Ca2-Xac-Ca3-Xad-Ca4-Xae-Ca5-Ca6-Xaf ??(I), having antimicrobial properties and compositions containing them, notably for the preservation of foodstuffs.
Type:
Application
Filed:
December 30, 2004
Publication date:
November 3, 2005
Applicant:
Centre National de la Recherche Scientifique - CNRS, a corporation of France
Inventors:
Philippe Bulet, Cecile Thouzeau, Yvon LeMaho
Abstract: A mutant Fab fragment of the 13B8.2 anti-CD4 antibody that binds a CD4 molecule and includes a mutation of at least one residue in a position situated in the VH variable domain of the heavy chain and/or in a position situated in the V? variable domain of the light chain.
Type:
Application
Filed:
January 5, 2005
Publication date:
October 13, 2005
Applicant:
Centre National de la Recherche Scientifique - CNRS, a corporation of France
Inventors:
Christian Devaux, Cedric Bes, Laurence Briant-Longuet, Martine Cerutti, Gerard Devauchelle, Thierry Chardes, Claude Granier, Bernard Pau
Abstract: A device for controlling propulsive gas mixing at an outlet of an aircraft jet engine, wherein propulsive jets are composed of a hot primary jet exiting from a nozzle of the jet engine and a secondary flux flowing between an external wall of the nozzle and an internal wall of the jet engine including a divergent trailing edge on the wall that generates conditions of a separation of the primary jet close to an existence limit value and a primary jet controller that enables control of passage of the primary jet from a separated state to a reattached state, and vice versa.
Type:
Application
Filed:
March 16, 2004
Publication date:
November 4, 2004
Applicant:
Centre National de la Recherche Scientifique - CNRS, a corporation of France
Inventors:
Jean-Paul Bonnet, Joel Delville, Erwan Collin, Jean Tensi, Eric Moreau, Gerard Touchard
Abstract: A method for identifying a motif or a combination of motifs having a Boolean state of predetermined mutations in a set of sequences including a) aligning a set of sequences of ordered motifs represented by a single-character code, b) comparing a reference sequence with the set of sequences aligned in step (a), c) identifying motifs not having mutated simultaneously or motifs having mutated simultaneously at least once on at least one sequence of the set and not having mutated on another sequence of the set.
Type:
Application
Filed:
December 11, 2003
Publication date:
October 14, 2004
Applicant:
Centre National de la Recherche Scientifique - CNRS, a corporation of France
Inventors:
Anne Vanet, Michaela Muller-Trutwin, Thomas Valere
Abstract: A pharmaceutical composition for the treatment, prevention or diagnosis of a tumoral pathology comprising an active agent which stabilizes an actin network of a cellular cytoskeleton.
Type:
Application
Filed:
December 18, 2003
Publication date:
September 30, 2004
Applicants:
Bioalliance Pharma, a corporation of France, Ecole Normale Superieure de Cachan, a corporation of France, Institut Gustave Roussy - IGR, a corporation of France, Centre National de la Recherche Scientifique - CNRS, a corporation of France
Inventors:
Christian Auclair, Valerie Amsellem, Martial Hervy, Frederic Subra
Abstract: The invention relates to a device for detecting chemical species present in a condensed medium, comprising means for determining the wavelength and the intensity values which are characteristic of electromagnetic transmission signals which are backscattered in response to a plurality of electromagnetic excitations, which have distinct wavelengths, of at least one chemical species which can be contained in the condensed medium; laser means producing a beam in order to excite the condensed medium; means for recording the wavelengths and the intensity values of backscattered electromagnetic transmission signals; and comparing and determining means for comparing the recorded intensity value of the electromagnetic signal, which is backscattered by the medium at a determined characteristic intensity value, with at least one corresponding transmission wavelength and excitation wave length.
Type:
Application
Filed:
December 1, 2003
Publication date:
July 15, 2004
Applicant:
Centre National de la Recherche Scientifique - CNRS, a corporation of France
Inventors:
Laurent Sarger, Philippe Fichot, Edouard Nau
Abstract: A Hall effect sensor formed in a multilayer structure including a thin active layer deposited on a substrate, wherein the substrate is an insulating, semi-insulating or semiconductor material of type p− or n+, respectively, to electrically isolate the active layer of the substrate and wherein the active layer is a weakly doped semiconductor material of type n− or p− in an exhaustion regime.
Type:
Application
Filed:
February 26, 2003
Publication date:
September 4, 2003
Applicant:
Centre National de la Recherche Scientifique - CNRS, a corporation of France
Inventors:
Jean-Louis Robert, Julien Pernot, Jean Camassel, Sylvie Contreras