Abstract: The present invention relates to compounds of Formula (I) below, to their pharmaceutically acceptable salts and to their isomers or mixtures of isomers: HetAr—X—CHR1R2 (I) in which: —HetAr represents a group chosen from: —X represents a linear, saturated or unsaturated, hydrocarbon-based chain comprising from 8 to 22 carbon atoms, optionally interrupted by an —NH— or —NH—CO— group, —R1 represents a hydrogen atom or an —OH, —O(C1-C6)alkyl, —OCO((C1-C6)alkyl), —OSO2((C1-C6)alkyl) or —OSO3H group, and —R2 represents a hydrogen atom or a (C2-C6)alkynyl, (C2-C6)alkenyl or (C3-C6)cycloalkyl group. The present invention also relates to a process for preparing the compounds of Formula (I), and also to the use thereof, especially in the treatment of neurodegenerative diseases.
Type:
Grant
Filed:
July 20, 2009
Date of Patent:
May 21, 2013
Assignee:
Centre National de la Recherche Scientifique (SNRS)
Inventors:
Fanny Schmidt, Bruno Figadere, Sylvia Rita Vozari, Pierre Champy, Xavier Franck
Abstract: The present invention relates to compositions and methods for producing therapeutic oligomeric compounds. In one aspect the invention relates to methods for administering the oligomeric compounds for the treatment and prevention of disease, for example, a fungal infection, bacterial infection, or cancer, in a mammal. In particular, the invention relates to medicaments comprising various novel oligomeric compounds and pharmaceutically acceptable salts thereof. The compounds of the invention may optionally be administered with at least one of a pharmaceutically acceptable excipient, pharmacologically active agent or a combination thereof.
Type:
Grant
Filed:
February 18, 2010
Date of Patent:
March 20, 2012
Assignees:
Centre National de la Recherche Scientifique (SNRS), ImmuPharma France SA
Inventors:
Aude Violette, Jean-Paul Briand, Robert H. Zimmer, Gilles Guichard
Abstract: The invention relates to a novel polynucleotide exhibiting a promoting transcription activity, polynucleotide-containing vectors and to the use thereof for the transcription of interesting sequences such as the production of non-cap RNA virus. Said invention also relates to host cells preferably of avian origin, containing a polynucleotide or the inventive vector.
Type:
Grant
Filed:
February 27, 2004
Date of Patent:
May 3, 2011
Assignees:
Institut Pasteur, Centre National de la Recherche Scientifique (SNRS), Universite Paris 7-Denis Diderot
Inventors:
Nadia Naffakh, Pascale Massin, Sylvie Van Der Werf