Abstract: This disclosure relates to a modified ?-helical bundle cytokine, with reduced activity via an ?-helical bundle cytokine receptor, wherein the ?-helical bundle cytokine is specifically delivered to target cells. Preferably, the ?-helical bundle cytokine is a mutant, more preferably it is a mutant interferon, with low affinity to the interferon receptor, wherein the mutant interferon is specifically delivered to target cells. The targeting is realized by fusion of the modified ?-helical bundle cytokine to a targeting moiety, preferably an antibody. This disclosure relates further to the use of such targeted modified ?-helical bundle cytokine to treat diseases. A preferred embodiment is the use of a targeted mutant interferon, to treat diseases, preferably viral diseases and tumors.

Abstract: Novel nucleic acids include non-integrative chimeric retroviral genomes including the 5? and 3? long terminal repeat sequences (LTRs) of the caprine lentivirus: the Caprine Arthritis Encephalitis Virus (CAEV) or of another retrovirus not integrating human cells and at least one viral gene of another retrovirus. A vector including such a nucleic acid, an immunogenic or vaccinal composition including the vector or the nucleic acid, as well as their use for treating and/or preventing an infection by a retrovirus or a disease induced by a pathogenic agent are also described.

Abstract: Multimodal optical and magnetic resonance imaging methods based on the use of persistent luminescence nanoparticles. Use of mesoporous persistent luminescence <<core-shell>> complexes for theranostic applications.

Abstract: The present disclosure relates to novel compositions of additives that result from mixing at least two thermoassociative and exchangeable copolymers and at least one compound for controlling the association of these two copolymers. A lubricant composition results from mixing at least one lubricating base oil, at least two thermoassociative and exchangeable copolymers and at least one compound for controlling the association of these two copolymers. The present disclosure also relates to a process for modulating the viscosity of a lubricant composition that results from mixing at least one lubricating base oil, at least two thermoassociative and exchangeable copolymers; as well as the use of a diol compound for modulating the viscosity of a lubricant composition.

Abstract: A system controls a cyclic motion of at least one body segment of an individual, including: at least one three-dimensional motion sensor, an attachment attaching the sensor to the body segment of the individual, a processor coupled to the sensor and capable of being carried by the individual, in which a reference cyclic motion and tolerance limits specific to the individual concerning at least one parameter of the motion to be controlled, which change depending on the progress thereof, are stored, the processor being configured to detect the cyclic motion, integrate the measurement data from the sensor in such a way as to calculate the parameter(s) of the motion of the segment and to compare, in real time, the parameter(s) of the measured motion (Ctr) with the parameter(s) of the previously recorded reference motion (Cref) of the individual, and a feedback device coupled to the processor, designed to provide the individual with real-time information on the compliance of the parameters(s) of the measured mo

Abstract: The present invention relates to a fusion protein comprising a Cas9 domain and a Spo11 domain, as well as the use of this protein to induce targeted meiotic recombinations in a eukaryotic cell.

Abstract: The present invention relates to polypeptide for engineering integrase chimeric proteins and their use in gene therapy. In particular, the present invention relates to a polypeptide which comprises the amino acid sequence ranging from the amino acid residue at position 617 to the amino acid residue at position 622 in SEQ ID NO: 1 or a function conservative thereof.

Abstract: An aqueous liquid medium for analyzing, purifying or separating species in an element having walls or for treating the walls of an element. The medium includes at least a polymer consisting of several polymeric segments. The polymer is of the irregular block-copolymer or irregular comb-like polymer type and has on the average at least three junction points between polymeric segments of different chemical or topological nature. The medium may be used in methods for analyzing, purifying or separating species and methods for treating an element to be contacted with a fluid and/or species contained in the fluid during preservation, transport, analysis, purification or separation of the fluid.

Abstract: The present invention relates to the use of complexes of water soluble porphyrins of formula (I) below wherein R1 to R10 and R1? to R10? are as defined in claim 1, with iron as catalysts for the selective electrochemical reduction of CO2 into CO, electrochemical cells comprising them, and methods for reducing electrochemically CO2 into CO using said complexes, or said electrochemical cells, thereby producing CO or syngas, in water as the solvent.

Abstract: F1 is formula (IIa) and F2 is formula (IIb): g and d are 0, 1, 2 or 3; R14 and R15 are C1-C4 or a cyclohexyl radical; R1 to R12 represents hydrogen or alkyl with 1 to 22 carbon atoms; x and y are integers, x+y is 0 to 2; R13 is oxygen or sulphur or divalent —CH2— n1, n2, m, p1 and p2 are an integer or equal to 0 and such that the molecular weight Mn of the polymer of formula (I) is between 400 and 100 000 g/mol; a process for preparation of the polymer; and use as adhesive in mixture with an amino compound with at least two amine groups.

Abstract: The invention relates to a method for assessing the depth of a crack near the surface of a material, characterized in that said method includes the following steps: heating an area located near the crack using of a heat source (2) that is periodically modulatable into a heat flow at a controllable frequency, a so-called “modulation frequency”, varying the frequency so as to vary the heat diffusion length between an initial value, less than the distance between the heated area and the crack, and a final value that is greater than the distance between the heated area and the crack; determining the variation, depending on the heat diffusion length, in a function on the basis of at least one derivative, relative to a space variable, of the amplitude of the sinusoidal component of the temperature, on the surface of the material and at the modulation frequency, at each point of a set of points of the crack so as to cause a first area of variation in the function to appear, wherein said function increases at a first

Abstract: The present invention relates to a compound of the following formula (I) or to a salt, hydrate, or pharmaceutically acceptable solvate thereof, in which R is a monosaccharide or disaccharide residue. The hydroxyl functions of the monosaccharide or disaccharide residue are, independently, optionally substituted for a (C1-C6) alkyl or —C(O)NH—(C1-C6) alkyl group. The invention also relates to the method for preparing said compound, to a pharmaceutical composition containing same, and to the use thereof as a drug, particularly for cancer treatment.

Abstract: The present invention relates to polynucleotides enabling the rapid, simple and specific detection of Group B Streptococcus highly-virulent ST-17 clones. The present invention also relates to the polypeptides encoded by said polynucleotides, as well as to antibodies directed or raised against said polypeptides. The present invention also relates to kits and methods for the specific detection of Group B Streptococcus highly-virulent ST-17 clones, using the polynucleotides, the polypeptides or the antibodies according to the invention.

Abstract: A copolymer having amphiphilic blocks includes at least one first hydrophilic block, obtainable from n-butyl acrylate and hydroxyethyl methacrylate monomers, and a second hydrophobic block likely to be obtained from a methyl methacrylate monomer. The copolymer is found to be particularly advantageous for use as an additive for manufacturing a polymer filtration membrane, particularly a PVDF membrane, particularly via a phase inversion method.

Abstract: The invention relates to a method for producing a support for the production of a semiconductor structure based on group III nitrides, characterised in that the method comprises the steps of: formation (100) of a buffer layer (20) on a substrate (10), said buffer layer comprising an upper surface layer based on group III nitrides, and deposition (200) of a crystalline layer (30) on the buffer layer, said crystalline layer being deposited from silicon atoms so as to cover the entire surface of the upper layer based on group III nitrides. The invention also relates to a support obtained by the method, to a semiconductor structure based on the support, and to the method for the production thereof.

Abstract: The invention is related to a digital-data mixing apparatus (2), a data processing system (1) and an associated method for mixing digital-data. The digital-data mixing apparatus comprises, integrated in a housing (7), input means (8) for receiving a plurality of bits (I1 . . . In) of input digital data (4), electromagnetic emission means (9) for generating a modulated electromagnetic beam (15) wherein said input digital data (4) are converted in simultaneous modulations of the modulated electromagnetic beam (15), electromagnetic scattering means (10) for scattering the modulated electromagnetic beam (15) in a scattered electromagnetic beam (19), receiving means (11) for converting the scattered electromagnetic beam (19) in bits (O1 . . . Om) of output digital data (5), and output means (12) for providing said output digital data (5).

Abstract: The present invention relates to a method for treating a Leber congenital amaurosis in a patient harbouring the mutation c.2991+1655 A>G in the CEP290 gene, comprising the step of administering to said patient at least one antisense oligonucleotide complementary to nucleic acid sequence that is necessary for preventing splicing of the cryptic exon inserted into the mutant c.

Abstract: The invention relates to the treatment of neurodegenerative diseases, in particular Alzheimer's disease, by inhibition of the synthesis of ?APP or of the activity of the A? peptide in the choroid plexus.

Abstract: The present invention relates to a method of assessing proprioceptive status by calculating a proprioceptive score Sp from absolute and variable errors between target angles and angles estimated and joint motion detection by the person tested, and/or between measured time of perceived movement of the joint of the tested person these proprioceptive scores of a person being associated with an assessment date and then stored with a date so as to serve as a reference when said person is monitored or when there is a comparison of said person with at least another person. The present invention also concerns an apparatus for the proprioceptive assessment of at least one joint, this apparatus having two movable parts (8, 9) with drive means (12, 15) particular for the pivoting of the movable parts (8, 9), means of determining the pivot angle for each of the first and second parts (8, 9) also being provided. Applications are in the field of proprioceptive assessment by movement of a limb of a person.

Abstract: Method for preparing a homogeneous collagen-based material by concentration of a collagen solution, includes bringing a collagen solution into contact by way of continuous injection and use of the material for tissue repair.