Patents Assigned to Centre National de la Recherche Scientifiques
  • Method for grafting polymers on metallic substrates
    Patent number: 10098984
    Abstract: A method of conferring modified properties, e.g. modified physical and/or biochemical properties, to a metallic substrate surface, including at least two steps being (i) a first step including at least exposing the substrate surface to a hetero-bifunctional anchoring molecule carrying at least a silane group and at least a A1 group, the A1 group being optionally introduced within the anchoring molecule via a preliminary functionalizing step, and (ii) a second step of exposing the substrate surface to a polymer carrying at least three groups A2 capable of reacting with A1 in a thiol-ene reaction, the number average molecular weight of the polymer being greater than 1 000 g/mol.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: October 16, 2018
    Assignees: INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITÉ
    Inventors: Vincent Semetey, Anne-Sophie Castanet
  • Skyrmion generation system
    Patent number: 10102956
    Abstract: Disclosed is a system (10) for generating skyrmions, including: a gun (12) including a wall-forming region (14) made from a first material, the region (14) defining an outer space (16) made from a second material different from the first material and an inner space (18) made from a third material different from the first material, the second material and the third material being magnetic materials; and a magnetization reversal device (26) that can reverse the magnetization at the interface between the region (14) and the inner space (18).
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: October 16, 2018
    Assignees: THALES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Vincent Cros, Noah Van Horne, Joao Sampaio, Albert Fert, Nicolas Reyren
  • Semiconducting pixel, matrix of such pixels, semiconducting structure for the production of such pixels and their methods of fabrication
    Patent number: 10103195
    Abstract: A pixel comprises three adjacent sub-pixels, formed by respective stacks of semi-conducting layers wherein: each sub-pixel comprises a first active layer, adapted for emitting a light at a first wavelength when an electric current passes through it; another sub-pixel comprises a second active layer, adapted for emitting a light at a second wavelength greater than the first wavelength; another sub-pixel comprises a third active layer, adapted for emitting a light at a third wavelength greater than the first wavelength and different from the second wavelength; at least one from among the second and third active layers being adapted for emitting light when it is excited by the light at the first wavelength emitted by the first active layer of the same sub-pixel. Semi-conducting structure and methods for the fabrication of such a pixel are provided.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: October 16, 2018
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Benjamin Damilano, Jean-Yves Duboz
  • Adjustable speed fast laser scanning system and two-photon microscope associated
    Patent number: 10101634
    Abstract: The present invention concerns a laser scanning system (18) comprising: —a first acousto-optical deflector (30) deflecting a beam in a first direction (X) to obtain a first deflected beam and comprising a first acousto-optical crystal on which is applied an acoustic wave whose frequency varies over time according to a first law of command, and —a second acousto-optical deflector (32) deflected the first deflected beam in a second direction (Y), defining an angle comprised between 85° and 95° with the first direction, and comprising a second acousto-optical crystal on which is applied an acoustic wave whose frequency varies over time according to a second law of command, characterized in that the first law of command and the second law of command are chosen so that the average speed of the laser scanning system (18) is superior to 10 radians per second.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: October 16, 2018
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (C.N.R.S.), Ecole Normale Superieure
    Inventors: Stéphane Dieudonne, Benjamin Mathieu
  • Use of a reverse-transcriptase inhibitor in the prevention and treatment of degenerative diseases
    Patent number: 10100307
    Abstract: The invention relates to the use of a reverse-transcriptase inhibitor in the prevention or treatment of a degenerative disease.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: October 16, 2018
    Assignees: Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale (INSERM), College de France, Sorbonne Universite
    Inventors: Alain Prochiantz, Julia Fuchs, Rajiv Joshi, François Xavier Blaudin De The, Hocine Rekaik, Olivia Massiani-Beaudoin
  • Hydrosilane/Lewis acid adduct, particularly aluminum, iron, and zinc, method for preparing same, and use of said same in reactions for reducing carbonyl derivatives
    Patent number: 10099986
    Abstract: Disclosed is an adduct between a Lewis acid, preferably aluminum trichloride, iron trichloride, or zinc dichloride, and a hydrosilane;—a method for preparing same; and a method for for reducing, particularly, an aldehyde, a ketone, an ?,?-unsaturated ketone, an imine, or an ?,?-unsaturated imine.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: October 16, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER
    Inventors: Claude Grison, Vincent Escande
  • Process for preparing synthesis intermediates using products of natural origin and use of the intermediates obtained
    Patent number: 10099987
    Abstract: Disclosed is a process for preparing a product of formula I: wherein the reaction is catalyzed both by thiamine or a thiamine salt and by ascorbic acid in a form which is free or salified or an organic acid salt of an alkaline metal, preferably sodium acetate, potassium tartrate, sodium succinate, or a reductone, preferably 2-hydroxypropanedial or 2,3-dihydroxycyclopent-2-ene-1-one in an organic solvent.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: October 16, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER
    Inventors: Claude Grison, Vincent Escande, Andrii Stanovych
  • SCREENING FOR ANTI-CANCER COMPOUNDS USING NETRIN-1 ACTIVITY
    Publication number: 20180291106
    Abstract: The subject matter of the present invention relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compound to interact with netrin-1 receptor and/or to inhibit the dimerization of the intracellular domain of the netrin-1 receptor expressed in tumor cells. The invention also relates to a method for predicting the presence of metastatic or aggressive cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of netrin-1. The invention further comprises kits and compounds as a medicament for the treatment of cancer such as metastatic breast cancer, related to the overexpression of netrin-1 by the tumor cells.
    Type: Application
    Filed: June 21, 2018
    Publication date: October 11, 2018
    Applicants: Centre National de la Recherche Scientifique (CNRS), Centre Leon Berard
    Inventors: Patrick Mehlen, Agnes Bernet, Julien Fitamant
  • METHOD FOR OBTAINING A PLANT EXTRACT AND ASSOCIATED COMPOSITIONS
    Publication number: 20180289761
    Abstract: The invention relates to a tablet or capsule containing a plant extract, to assist in the treatment or prevention of disorders or diseases. The tablet or capsule includes bioconverted products provided by fermenting Withania Somnifera extract, Emblica officinalis extract, and Bacopa monnieri extract.
    Type: Application
    Filed: May 21, 2018
    Publication date: October 11, 2018
    Applicants: Ethnodyne, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Chérif Rabhi, Léon Cariel, Jamal Ouazzani, Guillaume Arcile
  • METHOD FOR CLUSTERING NODES OF A TEXTUAL NETWORK TAKING INTO ACCOUNT TEXTUAL CONTENT, COMPUTER-READABLE STORAGE DEVICE AND SYSTEM IMPLEMENTING SAID METHOD
    Publication number: 20180293505
    Abstract: The invention relates to a method for clustering nodes of a network, said network comprising nodes associated with message edges of text data, the method comprising an initialization step of determination of a first initial clustering of the nodes, and a step of iterative inference of a generative model of text documents. Edges are modeled with a Stochastic Block Model (SBM) and the sets of documents between and within clusters are modeled according to a generative model of documents. The inference step comprises iteratively modelling the text documents and the underlying topics of their textual content, and updating the clustering as a function of said modelling, until a convergence criterion is fulfilled and an optimized clustering and corresponding optimized values of the parameters of the models are output.
    Type: Application
    Filed: April 6, 2017
    Publication date: October 11, 2018
    Applicants: Universite Paris Descartes, Universite Paris 1 Pantheon-Sorbonne, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Charles Bouveyron, Pierre Latouche
  • Device and method for remote polarimetric characterization
    Patent number: 10094766
    Abstract: According to one aspect, the invention relates to a device (100) for remote polarimetric characterization of a sample (S). It comprises a source (10) for emitting at least one incident light wave at at least one first wavelength (?E); a monomode optical fiber (30) in which the incident light wave is intended to propagate; a polarization state generator (PSG) arranged on the proximal side of the optical fiber; a reflector (40) intended to be arranged on the distal side of the optical fiber; a polarization state analyzer (PSA) arranged on the proximal side of the optical fiber and allowing, for each probe state of the incident wave generated by the polarization state generator, the polarization of the light wave obtained after propagation of the incident wave in the optical fiber (30), reflection from the distal side of the optical fiber and reverse propagation in the optical fiber (30), to be analyzed.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: October 9, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, Ecole Polytechnique
    Inventors: Antonello De Martino, Dominique Pagnoux, Jérémy Vizet, Sandeep Manhas, Jean-Charles Vanel, Stanislas Deby
  • Universal primers and the use thereof for the detection and identification of amphibia/fish species
    Patent number: 10093988
    Abstract: The invention relates to oligonucleotides and to the use thereof as universal primers for the detection and identification of amphibia/fish species, especially in complex and deteriorated substrates. The invention also relates to a method for detecting and identifying amphibia/fish species in samples collected from the environment (ground, water, faeces) or from industry (especially transformed products). The invention further relates to a kit for said detection.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: October 9, 2018
    Assignees: UNIVERSITE GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Pierre Taberlet, Eric Coissac, Tiayyba Riaz
  • Process for the manufacture of a component comprising a stack of a functional layer on a composite film
    Patent number: 10092928
    Abstract: A process of manufacturing component with a composite film including a matrix made of thermoplastic polymer and particles inside this matrix. This process includes heating the composite film in order for its temperature to exceed the glass transition temperature of its matrix, then when the composite film is softened, flattening an external face of the composite film by a smooth face resting directly over the whole of this external face, this smooth face forming part of the front face of a flexible membrane, the whole of the rear face of which, located on the side opposite the front face, is pushed against the composite film by a fluid, then cooling the composite film below the glass transition temperature, then withdrawing the membrane in order to mechanically separate its front face from the external face of the composite film.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: October 9, 2018
    Assignees: Commissariat a L'Energie Atomique et aux Energies Alternatives, Centre National de la Recherche Scientifique, Universite Joseph Fourier
    Inventors: Bernard Viala, Helene Takacs, Jean-Herve Tortai
  • Process for producing zirconia-based multi-phasic ceramic composites
    Patent number: 10093583
    Abstract: A process is described, for producing zirconia-based multi-phasic ceramic composite materials, comprising the steps of: providing at least one ceramic suspension by dispersing at least one ceramic zirconia powder in at least one aqueous medium to obtain at least one matrix for such composite material; providing at least one aqueous solution containing one or more inorganic precursors and adding such aqueous solution to such ceramic suspension to surface modify such ceramic zirconia powder and obtain at least one additived suspension; quickly drying such additived suspension to obtain at least one additived powder; heat treating such additived powder to obtain at least one zirconia powder coated on its surface by second phases; and forming such zirconia powder coated on its surface by second phases.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: October 9, 2018
    Assignees: Politecnico Di Torino, Centre National De La Recherche Scientifique, Decoram Medical Ceramica CMBH, Universite Claude Bernard Lyon, Institut National Des Sciences Appliquees De Lyon
    Inventors: Laura Montanaro, Paola Palmero, Jerome Chevalier, Helen Reveron, Tobias Fuerderer
  • RECEPTOR-BINDING DOMAINS LIGANDS FOR THE DETECTION, DIAGNOSIS AND TREATMENT OF PANCREATIC CANCER
    Publication number: 20180280549
    Abstract: Disclosed are methods for diagnosing pancreatic cancer, including measuring the expression level of ASCT1 and/or ASCT2 and/or XPR1. Also disclosed is a RBD ligand coupled to at least one contrast agent, that may be used as a probe for medical imaging.
    Type: Application
    Filed: October 5, 2016
    Publication date: October 4, 2018
    Applicants: METAFORA BIOSYSTEMS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE MONTPELLIER, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
    Inventors: Jawida TOUHAMI, Guangqi E, Donatella GIOVANNINI, Bruno ROBERT, Samuel SEVESTRE, Muriel BUSSON, Jean-Luc BATTINI, Vincent PETIT, Marc SITBON
  • SELECTIVE PARTIAL HYDROGENATION OF TERPENES USING A NICKEL-BASED CATALYST
    Publication number: 20180282243
    Abstract: A process for the selective partial hydrogenation of conjugated diene compounds includes at least one, preferably terminal, diene function and at least one additional carbon-carbon double bond, the process including reacting the conjugated diene compounds with hydrogen in the presence of a nickel-NHC based catalyst. The disclosure also relates to a reaction mixture that can be obtained at the end of the process and to a catalyst that can be used in the process. The disclosure also relates to the use of the reaction mixture.
    Type: Application
    Filed: May 6, 2016
    Publication date: October 4, 2018
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS ), TOTAL RAFFINAGE CHIMIE
    Inventors: Chloé THIEULEUX, Emmanuel LACÔTE, Delphine CROZET
  • TRILOBINE AND ITS NATURAL ANALOGS FOR USE AS A DRUG
    Publication number: 20180280379
    Abstract: Trilobine and its natural triple-bridged bisbenzylisoquinoline alkaloidal analogues as DNMT inhibitors for use as a drug for the treatment of cancer and neurological diseases and for cell reprogramming, in particular to prime for chemotherapy or immunotherapy.
    Type: Application
    Filed: October 3, 2016
    Publication date: October 4, 2018
    Applicants: PIERRE FABRE MEDICAMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Yoann MENON, Christophe LONG, François SAUTEL, Paola B. ARIMONDO
  • Glycoconjugates and use thereof as vaccine against serotype 3a and X
    Patent number: 10087242
    Abstract: The present invention relates to compounds derived from sugars which reproduce the epitopes of Shigella flexneri serotypes 3a and X and to the use thereof for the preparation of vaccine compositions. More specifically, the subject matter of the present invention relates to novel glycoconjugated compounds comprising oligosaccharides or polysaccharides described hereinafter, to the method for synthesizing these oligosaccharides or polysaccharides and glycoconjugates, to derivatives of these oligosaccharides or polysaccharides, to compositions containing same, and also to the use of the glycoconjugates for vaccination purposes. Finally, the present invention relates to methods for diagnosing a Shigella flexneri infection using one or more oligosaccharides or polysaccharides or conjugates thereof.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: October 2, 2018
    Assignees: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS DESCARTES
    Inventors: Laurence Mulard, Julien Boutet, Catherine Guerreiro, Farida Nato, Philippe Sansonetti, Armelle Phalipon
  • Method for identifying the anisotropy of the texture of a digital image
    Patent number: 10089748
    Abstract: A method for determining an extent of anistropy of texture of an image in a manner that avoids inaccuracies arising from interpolation.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: October 2, 2018
    Assignees: UNIVERSITÉ D'AIX-MARSEILLE, Centre National de la Recherche Scientifique
    Inventor: Frédéric Joseph Pierre Richard
  • Camelid single-domain antibody directed against phosphorylated tau proteins and methods for producing conjugates thereof
    Patent number: 10087245
    Abstract: The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: October 2, 2018
    Assignees: F. HOFFMANN-LA ROCHE AG, INSTITUT PASTEUR, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Pierre Lafaye, Sylvie Bay, Benoit Delatour, Marc Dhenain, Charles Duyckaerts, Tengfei Li, Matthias Vandesquille, Christian Czech, Fiona Grueninger