Patents Assigned to Centre National de la Recherche
  • Prevention and/or treatment of hearing loss or impairment
    Patent number: 11679140
    Abstract: The present invention relates to the use of gasdermin, in particular of gasdermin A, gasdermin B, gasdermin C, gasdermin D, DFNA5 or DFNB59 (or pejvakin), and more particularly pejvakin for modulating cellular redox homeostasis. A particularly preferred use of gasdermin, in particular of gasdermin A, gasdermin B, gasdermin C, gasdermin D, DFNA5 or DFNB59 (or pejvakin), and more particularly pejvakin in the context of the present invention is as an antioxidant. The present invention also concerns a virally-mediated gene therapy for restoring genetically-impaired auditory and vestibular functions in subjects suffering from an Usher syndrome. More precisely, this gene therapy takes advantage of an AAV2/8 vector expressing at least one USH1 gene product, preferably SANS.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: June 20, 2023
    Assignees: INSTITUT PASTEUR, Centre National de la Recherche Scientifique (CNRS), Universite Clermont Auvergne, Sorbonne Universite
    Inventors: Christine Petit, Paul Avan, Sedigheh Delmaghani, Jean Defourny, Asadollah Aghaie, Saaid Safieddine, Alice Emptoz
  • Compounds, functionalised dioxaborolane or dioxaborinane derivatives, method for preparing same and uses thereof
    Patent number: 11680074
    Abstract: The invention relates to functionalised dioxaborolane or dioxaborinane derivatives of formula (I), wherein R1 is covalently bonded to the boron atom by a carbon atom; one of R2, R3, R?3 or R4 is a radical of formula —X; or one of R1, R2, R3, R?3 or R4 is a radical of formula —X; and X is a functionalised radical. The invention relates to the method for preparing same and the uses thereof.
    Type: Grant
    Filed: January 6, 2022
    Date of Patent: June 20, 2023
    Assignees: ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Ludwik Leibler, Renaud Nicolay
  • CHEMICAL FUNCTIONALIZATION OF CELLULOSIC MATERIALS WITH DIAZO COMPOUNDS
    Publication number: 20230183383
    Abstract: A method for chemically functionalizing a cellulosic material using a diazo compound, and the functionalized cellulosic materials obtained by the method. The cellulosic materials may be functionalized with a functional groups selected from hydrophobic agents, catalyzing agents, sensing agent, diagnostic agents, printing agents chelating agents, ligands, antioxidants, antimicrobial agents, or drugs. Also, the uses of functionalized cellulosic materials obtained by the method in a variety of applications.
    Type: Application
    Filed: May 19, 2021
    Publication date: June 15, 2023
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, NANTES UNIVERSITE
    Inventors: François-Xavier FELPIN, Guillaume BRETEL, Erwan LE GROGNEC, Marie DENIS, Samuel CALDERONI
  • Dynamic Covalent Hydrogels, Precursors Thereof and Uses Thereof
    Publication number: 20230181462
    Abstract: The present invention provides crosslinking pairs of hydrogel precursor polymers, dynamic covalent hydrogels prepared from such crosslinking pairs of hydrogel precursors, pharmaceutical compositions comprising such precursors or hydrogels and uses thereof in a variety of applications.
    Type: Application
    Filed: March 10, 2021
    Publication date: June 15, 2023
    Applicants: Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Nantes Universite
    Inventors: Vianney Delplace, Jérôme Guicheux, Catherine Le Visage, Arnaud Tessier
  • Synthetic Single Domain Library
    Publication number: 20230183675
    Abstract: The present invention relates to the identification of a fully humanized single domain antibody scaffold as well as its use in generating synthetic single domain antibodies. The invention further relates to antigen-binding proteins comprising said single domain antibody scaffold and their use in therapy.
    Type: Application
    Filed: May 20, 2021
    Publication date: June 15, 2023
    Applicants: Institut Curie, Centre National de la Recherche Scientifique
    Inventors: Franck Perez, Sandrine Moutel
  • PROCESS FOR FLUORINATION OF AN LLZO GARNET
    Publication number: 20230187687
    Abstract: The invention relates to a fluorination process consisting in bringing an inorganic compound M into contact with an atmosphere comprising difluorine gas, the inorganic compound M being a garnet based on the elements Li, La, Zr, A and O and for which the relative composition of the Li, La, Zr and A cations corresponds to the formula (I): LixLa3ZrzAw.
    Type: Application
    Filed: April 29, 2021
    Publication date: June 15, 2023
    Applicants: Solvay SA, Centre National de la Recherche Scientifique, Clermont Auvergne INP, Universite Clermont Auvergne
    Inventors: Laure Bertry, Réka Toth, Thierry Le Mercier, Valérie Buissette, Katia Guerin, Marc Dubois, Michaël Herraiz
  • Analytical methods for cell free nucleic acids and applications
    Patent number: 11674183
    Abstract: The present invention is directed to an in vitro method of detecting cell free nucleic acids, preferably cell free DNA (cfDNA) in a body fluid sample from an individual or a patient, wherein the method comprises the step of accurately and sensitively determining the concentration of cell free nucleic acid in the sample and/or determining the concentration or amount of said cell free nucleic acid of a size range and/or the index of integrity or size fraction ratio (SFR) of said cell free nucleic acid and/or the determination of the presence of genetic polymorphisms (such as known Single Nucleotide Polymorphisms (SNPs) or mutations). The invention encompasses also a method to discriminate body fluid individuals where cfDNA are highly released by comparing the size profile obtained for at least one of three size ranges of cfDNA.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: June 13, 2023
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Alain Thierry, Franck Molina
  • Continuous, solvent-free and non-enzymatic peptide synthesis by reactive extrusion
    Patent number: 11673912
    Abstract: A continuous, solvent-free and non-enzymatic method for synthesizing a compound of formula (I): Ra-POLYPEP-Rc (I) wherein: POLYPEP is a poly-amino acid compound, Ra and Rc are as specified, the method including the steps of: a) feeding an extrusion reactor with (1) a compound of formula (II) Ra-PEPNt-Rg (II) wherein; PEPNt is a mono- or a poly-amino acid compound, Ra and Rg are as specified, and (2) a compound of formula (III) H-PEPCt-Rc (III) wherein: PEPCt is a mono- or a poly-amino acid compound, and Rc is as defined in the absence of any solvent, so that the compound of formula (II) and the compound of formula (III) react together for generating a compound of formula (I), and b) collecting the compound of formula (I) from the extrusion reactor.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: June 13, 2023
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER, ECOLE DES MINES D'ALES, ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS
    Inventors: Yves Yeboue, Benjamin Gallard, Nicolas Le Moigne, Frédéric Lamaty, Jean Martinez, Thomas-Xavier Metro
  • PROGNOSIS METHOD OF ACUTE MYELOID LEUKAEMIA
    Publication number: 20230175068
    Abstract: A method for in vitro prognosis of the outcome of an individual afflicted by an acute myeloid leukaemia. The method includes the following steps: (a) measuring the expression level of genes involved in 5 DNA repair pathways, (b) calculating a score value for each DNA repair pathway group of genes, and (c) classifying the individual as having a good or a bad outcome.
    Type: Application
    Filed: April 14, 2021
    Publication date: June 8, 2023
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER, UNIVERSITÉ DE MONTPELLIER
    Inventors: Jérôme MOREAUX, Ludovic GABELLIER, Caroline BRET
  • Use of 4-Phenylbutyric Acid and/or 3-Phenylbutyric Acid and/or 2-Phenylbutyric Acid in Preventing and Treating Cryptogamic Diseases
    Publication number: 20230172201
    Abstract: The present invention relates to the use of 2-phenylbutyric acid, or 3-phenylbutyric acid, or 4-phenylbutyric acid, or one of their salts, or one of their combinations, to combat cryptogamic diseases caused by fungi and oomycetes. The present invention also relates to the use of these compounds and these combinations as fungicidal or fungistatic agents for the prevention or the curative treatment of cryptogamic diseases.
    Type: Application
    Filed: May 19, 2021
    Publication date: June 8, 2023
    Applicants: Institut National de Recherche Pour L'Agriculture, L'Alimentation et L'Environnement, Institut des Sciences et Industries du Vivant et de L'Envirinnement, Centre National de la Recherche Scientifique, Universite de Bourgogne, Université Bourgogne -Franche-Comté, Institut National Superieur des Sciences Agronomiques de l'Alimentation et de l'Environnement
    Inventors: Jean-Luc Cacas, Damien Vasselon, Olivier Lamotte, Benoît Poinssot, Anne-Sophie Walker
  • AN INSULIN SENSITIZER FOR USE IN THE PREVENTION AND/OR TREATMENT OF THE DAMAGES CAUSED BY RETINAL DETACHMENT
    Publication number: 20230172919
    Abstract: An insulin sensitizer for use in the prevention and/or treatment of the damages caused by retinal detachment, and in particular for preventing or treating the loss of vision induced by retinal detachment. Also, a composition including the insulin sensitizer for use in the prevention and/or treatment of the damages caused by retinal detachment and a device including the composition.
    Type: Application
    Filed: March 26, 2021
    Publication date: June 8, 2023
    Applicants: SORBONNE UNIVERSITE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Florian SENNLAUB, Jean-Baptiste CONART, José-Alain SAHEL
  • (BI)METAL SULFIDE POLYMER COMPOSITE MATERIAL, AND ITS USE AS CATALYST FOR HYDROGEN PRODUCTION
    Publication number: 20230173471
    Abstract: A composite material made of an amorphous (bi)metal sulfide nanoparticles directly linked, through coordinate covalent bonds, to a sulfur-containing polymer and a method of preparation of the composite material. The composite material can also be used as a catalyst for hydrogen production. Finally, a proton-exchange membrane (PEM) electrolyser and a photoelectrochemical cell, can both including the composite material.
    Type: Application
    Filed: April 28, 2021
    Publication date: June 8, 2023
    Applicants: TOYOTA MOTOR EUROPE, COMMISSARIAT À L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Adina MOROZAN, Hannah JOHNSON, Sachin KINGE, Vincent ARTERO
  • ARRAY OF QUANTUM DOTS WITH SPIN QUBITS
    Publication number: 20230180635
    Abstract: An elementary cell for a two-dimensional array of quantum dots, said elementary cell extending along a main plane and including: a plurality of sites occupied by quantum dots capable of confining at least one spin qubit and including at least: a first quantum dot, a second quantum dot adjacent to the first quantum dot in a first direction of the main plane, and a third quantum dot adjacent to the first quantum dot in a second direction of the main plane; and a first blocking site adjacent to the second and third quantum dots, towards which a spin qubit cannot be displaced.
    Type: Application
    Filed: October 13, 2022
    Publication date: June 8, 2023
    Applicants: Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Centre National de la Recherche Scientifique
    Inventors: Benoit Bertrand, Tristan Meunier, Pierre-André Mortemousque
  • Protein-drug conjugates and their use in the treatment of cancers
    Patent number: 11666657
    Abstract: This invention pertains to protein-drug conjugates that may be used in the treatment of cancers and to pharmaceutical compositions containing the same. The protein-drug conjugate has the following formula (I), wherein: L is a cysteine-containing protein residue linked through one or more of the cysteine groups of the protein, R1 is selected from the group consisting of arylene, arylene-heteroarylene, heteroarylene-arylene and heteroarylene, n is an integer from 0 to 5, p and q are independently 0 or 1, R2, R3 and Z are spacers, u is 0 or 1 and T is a cleavable unit sensitive to hydrolases, k is 1 or 2 and D is a cytotoxic drug residue selected from dolastatin residues, which may be identical to or different from each other when k is 2, m is the mean payload-to-protein ratio (PPR) of the conjugate, which ranges from 0.1 to 16.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: June 6, 2023
    Assignees: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Alain Wagner, Sergii Kolodych, Oleksandr Koniev
  • Bromide source for use in treating autism spectral disorder
    Patent number: 11666599
    Abstract: The present invention relates to a novel pharmaceutical use of bromide, i.e. the treatment of autism spectral disorder (ASD).
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: June 6, 2023
    Assignees: INSERM, INTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, INRA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, CNRS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG
    Inventors: Sébastien Roux, Thierry Plouvier, Julie Le Merrer, Jérôme Becker
  • Compositions and method for the treatment of x-linked centronuclear myopathy
    Patent number: 11666628
    Abstract: The present disclosure relates to a BIN1 protein or a BIN1 nucleic acid sequence producing or encoding the same, for a use in the treatment of X-linked centronuclear myopathy. The present invention provides compositions and methods for treatment of X-linked centronuclear myopathy. The present invention relates to a method of delivering the BIN1 polypeptide to subjects with X-linked centronuclear myopathy.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: June 6, 2023
    Assignees: UNIVERSITE DE STRASBOURG, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jocelyn Laporte, Valentina Lionello, Belinda Cowling
  • ANTIBODY AND USES THEREOF
    Publication number: 20230167179
    Abstract: An isolated monoclonal antibody against the interleukin 1-alpha or beta receptor antagonist, known as IL-1RA. The antibody inhibits the interaction of IL-1RA with the membrane-binding chain thereof, the interleukin-1 receptor. Also, nucleic acid molecule encoding for a light chain of the monoclonal antibody, and a nucleic acid molecule encoding for a heavy chain of the monoclonal antibody. Also, a method for treating an inflammatory, infectious or autoimmune disease, which includes administering the isolated monoclonal antibody or a nucleic acid coding for the isolated monoclonal antibody, and a method of or the diagnosis of an inflammatory, infectious or autoimmune diseases, which includes contacting a biological sample with the isolated monoclonal antibody.
    Type: Application
    Filed: April 30, 2021
    Publication date: June 1, 2023
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE RENNES 1
    Inventors: Hugues GASCAN, Sylvie CHEVALIER
  • Metal/metal chalcogenide electrode with high specific surface area
    Patent number: 11661662
    Abstract: The present invention relates to an electrode comprising an electrically conductive substrate of which at least one portion of the surface is covered with a metal deposit of copper, the surface of said deposit being in an oxidised, sulphurised, selenised and/or tellurised form and the deposit having a specific surface area of more than 1 m2/g; a method for preparing such an electrode; and a method for oxygenising water with dioxygen involving such an electrode.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: May 30, 2023
    Assignees: Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite
    Inventors: Marc Fontecave, Victor Mougel, Ngoc Huan Tran
  • System for controlling speed transition and thrust vectorisation in a multiple-shaped nozzle by secondary injection
    Patent number: 11661910
    Abstract: A mixing tube with multiple shapes is provided, allowing additional injection of gas in order to keep the flow detached from the second shape in an ascent phase and to bring about, in a descent phase, a controlled detachment as a result of the change of slope between the two shapes. A propulsion nozzle for an engine of a spacecraft or aircraft is provided including such a mixing tube and a method for controlling the speed transition of the propulsion gases in such a nozzle in accordance with the altitude. Also, a method is provided for vectorising the thrust in such a nozzle by radial and asymmetrical injection of gas and a control method which prevents re-attachment of the jet to the second shape of such a propulsion nozzle for an engine of a spacecraft when it is in the take-off or landing phase.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: May 30, 2023
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'ORLEANS, UNIVERSITE D'EVERY-VAL D'ESSONNE
    Inventors: Luc Leger, Vladeta Zmijanovic, Mohamed Sellam, Amer Chpoun
  • METHOD FOR CALCULATING A STREAM OF AT LEAST ONE GAS EMITTED BY A SOURCE INTO THE ATMOSPHERE, MEASUREMENT METHOD, AND ASSOCIATED SYSTEM AND KIT
    Publication number: 20230160789
    Abstract: This method comprises the following steps retrieving data about amounts of at least one gas, said data being measured in the atmosphere at a distance from the source along a plurality of lines parallel to a first direction; integrating the amounts read on each line in the first direction in order to obtain an integrated overall amount on each line; integrating the product of the integrated overall amounts on each line and a wind speed present on the line in a second direction perpendicular to the first direction, in order to obtain a raw flow of gas; determining the flow of gas emitted by the source based on the raw flow of gas.
    Type: Application
    Filed: April 8, 2021
    Publication date: May 25, 2023
    Applicants: Centre national de la recherche scientifique, UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE, TotalEnergies OneTech
    Inventors: Ludovic DONNAT, Olivier DUCLAUX