Patents Assigned to Centre Nationale de Recherche Scientifique
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Patent number: 11097275Abstract: A microfluidic device for performing physical, chemical or biological treatment to at least one packet without contamination.Type: GrantFiled: February 7, 2020Date of Patent: August 24, 2021Assignees: INSTITUT CURIE, CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUEInventors: Jean-Louis Viovy, Max Chabert, Kevin Dorfman
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Patent number: 10465055Abstract: The present invention relates to method for treating a substrate or a surface thereof bearing Si—H groups to confer to it a physical and/or biochemical surface-modified property, wherein it comprises at least a step consisting of exposing, within a liquid medium, said substrate or a surface thereof with at least a polymer, said polymer containing: at least three reactive sites able to attach to said substrate or said surface by reacting with Si—H groups and further creating covalent bonds, and at least a molecule or a part thereof able to confer said modified property to said substrate or said surface thereof, said step being carried out in efficient conditions to promote the covalent grafting of said polymer to said substrate or surface thereof and the molecular weight of said polymer being greater than 1000 g/mol.Type: GrantFiled: October 3, 2007Date of Patent: November 5, 2019Assignees: CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE, INSTITUT CURIEInventors: Vincent Semetey, Nasreddine Kebir
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Patent number: 10130595Abstract: A method of treating a disease selected from the group consisting of cancer, Duchenne muscular dystrophy, AIDS, and progeria, that includes administering to a patient in need thereof an effective quantity of at least one compound of formula (IV) or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 3, 2015Date of Patent: November 20, 2018Assignees: CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE DE MONTPELLIERInventors: Jamal Tazi, David Grierson, Florence Mahuteau-Betzer, Pierre Roux
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Patent number: 9890196Abstract: A method for the in vitro diagnosis of colorectal cancer by determining the presence of the Ezrin tumor marker in a biological sample taken from a patient suspected of having colorectal cancer using at least one anti-Ezrin monoclonal antibody directed against an Ezrin epitope chosen from the epitopes of sequence SEQ ID No.1, SEQ ID No.2, SEQ ID No.3, SEQ ID No.4+SEQ ID No.5, SEQ ID No.6+SEQ ID No.7 and SEQ ID No.8. Said method can be used for early diagnosis, screening, therapeutic follow-up and prognosis, and also for relapse diagnosis in relation to colorectal cancer.Type: GrantFiled: December 12, 2012Date of Patent: February 13, 2018Assignees: BIOMERIEUX, CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE, INSTITUT CURIEInventors: Yasemin Ataman-Onal, Sandrine Busseret, Jean-Philippe Charrier, Genevieve Choquet-Kastylevsky
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Patent number: 9719065Abstract: A method of forming a multilayer aggregate of objects in a channel including a liquid, the method including: a) providing objects at first and second superposed regions of the channel, b) obtaining first and second aggregates of objects, optionally by applying transverse acoustic waves, preferably stationary waves, within each region to objects, and c) bringing the first and second aggregates into contact to form the multilayer aggregate of objects by submitting the first and second aggregates to: gravity in absence of acoustic waves, or to acoustic waves, optionally stationary waves, inducing displacement of the first and second aggregates toward each other.Type: GrantFiled: February 5, 2013Date of Patent: August 1, 2017Assignee: CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUEInventors: Despina Bazou, Mauricio Hoyos, Luz Angelica Castro Camacho
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Patent number: 9637475Abstract: A method of preventing, inhibiting, or treating cancer that includes contacting a cell with at least one compound of formula (Ia) or a pharmaceutically acceptable salt thereof: where: R independently represents a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —CN group, a hydroxyl group, a —COOR1 group, a (C1-C3)fluoroalkyl group, a —NO2 group, a —NR1R2 group, or a (C1-C3)alkoxy group; R? is a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —NO2 group, a (C1-C3)alkoxy group, or a —NR1R2 group; and R1 and R2 are a hydrogen atom or a (C1-C3)alkyl group.Type: GrantFiled: July 1, 2015Date of Patent: May 2, 2017Assignees: ABIVAX, CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE DE MONTPELLIERInventors: Pierre Roux, Florence Mahuteau, Romain Najman, Jamal Tazi, Gilles Gadea, Didier Scherrer, Carsten Brock, Nathalie Cahuzac
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Patent number: 9556075Abstract: Product formed from a ceramic material, at least part of the said product not being formed from amorphous silica and including pores and satisfying the following criteria (a), (b) and (c): (a) at least 70% by number of the said pores are frustoconical tubular pores extending substantially parallel to each other in a longitudinal direction; (b) in at least one cross-section plane, the mean size of the cross sections of the said pores is greater than 0.15 ?m and less than 300 ?m; (c) in at least one cross-section plane, at least 50% by number of the pores have a convexity index Ic of greater than 87%, the convexity index of a pore being equal to the ratio Sp/Sc of the surfaces Sp and Sc delimited by the perimeter and by the convex envelope of the said pore, respectively.Type: GrantFiled: April 1, 2011Date of Patent: January 31, 2017Assignees: SAINT-GOBAIN CENTRE DE RECHERCHIES ET D'ETUDES EUROPEEN, CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUEInventors: Sylvain Deville, Celine Viazzi
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Patent number: 9433674Abstract: A method of vaccination against a viral, bacterial or non-infectious disease includes administering an effective dose of a prime vaccine and then an effective dose of a boost vaccine. Each one of the prime vaccine and the boost vaccine includes an active principle. The prime vaccine includes, as the active principle, a colloidal synthetic bioresorbable vector that includes at least one protein substance. The boost vaccine includes, as the active principle, a viral vector that includes at least one nucleotide sequence which codes for a protein substance corresponding to the at least one protein substance of the synthetic vector.Type: GrantFiled: February 12, 2015Date of Patent: September 6, 2016Assignee: CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUEInventors: Yasemin Ataman-Onal, Thierry Delair, Bernard Verrier
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Patent number: 9233931Abstract: The present invention relates to a compound of one of the formulas I to XXI; a pharmaceutical composition comprising at least one such compound; and the use of at least one such compound in preparing a drug to treat, in a subject, a genetic disease resulting from at least one splicing anomaly.Type: GrantFiled: November 4, 2013Date of Patent: January 12, 2016Assignees: CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUESInventors: Jamal Tazi, David Grierson, Florence Mahuteau-Betzer, Pierre Roux
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Patent number: 9162953Abstract: The present invention relates to a process for creating a Carbon-Carbon bond (C—C) or a Carbon-Heteroatom bond (C-HE) by reacting a compound carrying a leaving group with a nucleophilic compound carrying a carbon atom or a heteroatom (HE) that can substitute for the leaving group, creating a C—C or C-HE bond, wherein the reaction takes place in the presence of an effective quantity of a catalytic system comprising iron and copper.Type: GrantFiled: July 4, 2007Date of Patent: October 20, 2015Assignees: CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIERInventors: Marc Taillefer, Ning Xia, Armelle Ouali
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Patent number: 9108919Abstract: A method of preventing, inhibiting, or treating cancer that includes contacting a cell with at least one compound of formula (Ia) or a pharmaceutically acceptable salt thereof: where: R independently represents a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —CN group, a hydroxyl group, a —COOR1 group, a (C1-C3)fluoroalkyl group, a —NO2 group, a —NR1R2 group, or a (C1-C3)alkoxy group; R? is a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —NO2 group, a (C1-C3)alkoxy group, or a —NR1R2 group; and R1 and R2 are a hydrogen atom or a (C1-C3)alkyl group.Type: GrantFiled: November 22, 2013Date of Patent: August 18, 2015Assignees: ABIVAX, CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE MONTPELLIER 2Inventors: Pierre Roux, Florence Mahuteau, Romain Najman, Jamal Tazi, Gilles Gadea, Didier Scherrer, Carsten Brock, Nathalie Cahuzac
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Patent number: 9000135Abstract: The present invention relates to a compound of general formula (I): in which: X is OH, NH2, NHOH or RNH, where R may be a linear or branched, saturated or unsaturated, C1-C10 alkyl radical, Y is H, or an electron-withdrawing group, in particular selected from NO2, CF3 or a halogen, R1 and R2 are H or a linear or branched, saturated or unsaturated, C1-C10 alkyl radical, F is a reactive functional group that can be activated by click chemistry.Type: GrantFiled: May 18, 2011Date of Patent: April 7, 2015Assignees: Centre Nationale de Recherche Scientifique, Universite de PoitiersInventors: Sebastien Papot, Mickael Thomas
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Patent number: 8962552Abstract: The invention relates to a water-dispersible derivative of a therapeutic agent having a low water solubility that comprises at least one molecule of said agent covalently bonded to at least one molecule of a hydrocarbon derivative having a squalenic structure or the like. The invention further relates to corresponding nanoparticles.Type: GrantFiled: November 27, 2008Date of Patent: February 24, 2015Assignees: Centre Nationale de Recherche Scientifique, Universite Paris SU XIInventors: Patrick Couvreur, Harivardhan Reddy Lakkireddy, Franco Dosio, Barbara Stella, Luigi Cattel
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Patent number: 8743124Abstract: The invention relates to a method of generating at least one synthesized image of at least a portion of a head of hair in movement, the method comprising the steps consisting in calculating a shape of at least one director hair by applying to the at least one director hair at least one mechanical model of an inextensible rod having inertia and stiffnesses in twisting and in bending, and in generating at least one virtual image of the at least one portion of the head of hair from the shape of the director hair.Type: GrantFiled: June 22, 2007Date of Patent: June 3, 2014Assignee: Centre Nationale de Recherche ScientifiqueInventors: Basile Audoly, Bernard Querleux, Florence Bertails, Jean-Luc Leveque, Marie-Paule Cani
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Publication number: 20140080831Abstract: A method of preventing, inhibiting, or treating cancer that includes contacting a cell with at least one compound of formula (Ia) or a pharmaceutically acceptable salt thereof: where: R independently represents a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —CN group, a hydroxyl group, a —COOR1 group, a (C1-C3)fluoroalkyl group, a —NO2 group, a —NR1R2 group, or a (C1-C3)alkoxy group; R? is a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —NO2 group, a (C1-C3)alkoxy group, or a —NR1R2 group; and R1 and R2 are a hydrogen atom or a (C1-C3)alkyl group.Type: ApplicationFiled: November 22, 2013Publication date: March 20, 2014Applicants: CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE, UNIVERSITE MONTPELLIER 2, SOCIETE SPLICOS, INSTITUT CURIEInventors: Pierre ROUX, Florence MAHUTEAU, Romain NAJMAN, Jamal TAZI, Gilles GADEA, Didier SCHERRER, Carsten BROCK, Nathalie CAHUZAC
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Patent number: 8652431Abstract: A method of synthesis of a metal fluorophosphate having the following general formula (1): XaMb(PO4)cFd (1), in which: X is an alkaline metal selected among sodium (Na) and lithium (Li) or a mixture of said metals; M is a transition metal selected among the following elements: Co, Ni, Fe, Mn, V, Cu, Ti, Al, Cr, Mo, Nb or a combination of at least two of said metals, 0?a?5; 0.5?b?3; 0.5?c?3; and d is an integer equal to 1, 2 or 3. The method contains an electric-field-activated sintering process for a mixture (1) formed by at least one first phosphate-containing solid precursor and at least one second fluorine-containing solid precursor.Type: GrantFiled: November 4, 2010Date of Patent: February 18, 2014Assignees: Commissariat a l'Energie Atomique et aux Energies Alternatives, Centre Nationale de Recherche ScientifiqueInventors: Sébastien Patoux, Carole Bourbon, Erwan Dumont-Botto, Mickael Dolle, Patrick Rozier
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Patent number: 8568911Abstract: The liquid electrolyte storage battery includes a battery case consisting of a top wall, a bottom wall and a side wall delineating a cavity. The top wall includes an electrolyte injection hole. The battery case also includes a lateral hole formed in a bottom area of the side wall and defining a tank area for a liquid electrolyte solution. The tank area is delineated by the bottom wall, the side wall and a plane parallel to the bottom wall and passing via the lower edge of the lateral hole.Type: GrantFiled: September 17, 2009Date of Patent: October 29, 2013Assignees: Commissariat a l'Energie Atomique et aux Energies Alternatives, Centre Nationale de Recherche ScientifiqueInventors: Nelly Giroud, Pierre Jost, Helene Rouault
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Patent number: 8545770Abstract: A method for treating the surface of a polymerio substrate, including the following steps: providing a first polymeric substrate; contracting at least one part of one face of the first substrate with some liquid solvent system, the liquid solvent system containing at least a first volatile compound and at least a second compound having a low molecular weight and able to swell and/or soften the polymeric material forming the face; letting at least the volatile compound to evaporate from the face of the first substrate and; contracting the so-treated face of first substrate with a third material.Type: GrantFiled: December 11, 2007Date of Patent: October 1, 2013Assignees: Institue Curie, Centre Nationale de Recherche Scientifique, Fluigent Paris-Biotech-Faculte de MedecineInventors: Jean-Louis Viovy, Jeremie Weber, Debjani Paul, Laurent Malaquin, Sandrine Miserere
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Patent number: 8476323Abstract: The invention relates to a fluorocarbon polymer material comprising a backbone with the following unit: wherein: Z is a quaternary ammonium group, Y1 and Y2 are each independently an oxygen heteroatom or a sulphur heteroatom, A is a fluorinated or perfluorinated straight chain having from 2 to 6 carbon atoms, R1 represents a phenyl or aryl group or a —CR2R3— group, and R4 is selected from the group consisting of a hydrogen atom, a straight or branched, cyclic or acyclic, alkyl or halogenated alkyl group, and a group represented by the following formula: m is an integer comprised between 0 and 10, preferably between 0 and 3; m?, n and r are integers, each independently equal to 0 or 1; and s is equal to 0 or 1, provided that when s is equal to 0, then R4 is different from the hydrogen atom.Type: GrantFiled: February 2, 2011Date of Patent: July 2, 2013Assignees: Commissariat a l'Energie Atomique et aux Energies Alternatives, Centre Nationale de Recherche Scientifique, Ecole Nationale Superieure de Chimie de MontpellierInventors: Audrey Martinent, Ali Alaaeddine, Bruno Ameduri, Philippe Capron
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Patent number: 8421559Abstract: The present invention relates to the field of acoustic wave devices, and particularly to that of transducers capable of operating at very high frequencies, from a few hundred MHz to several gigahertz, and its subject is more particularly an interface acoustic wave device including at least two substrates and a layer of ferroelectric material, the latter being contained between a first electrode and a second electrode and having first positive-polarization domains and second negative-polarization domains, the first and second domains being alternated, wherein the assembly constituted by the first electrode, the layer of ferroelectric material, and the second electrode is contained between a first substrate and a second substrate.Type: GrantFiled: September 17, 2009Date of Patent: April 16, 2013Assignees: Etat Francais Represente par le Delegue General pour l'Armement, Centre Nationale de Recherche Scientifique, Université de Franche ComteInventors: Roger Petit, Sylvain Ballandras, Emilie Courjon, Dorian Gachon