Patents Assigned to Centrillion Technologies Taiwan Co. LTD.
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Patent number: 10913070Abstract: A microarray carrier assembly including a scan tray and a plurality of microarray blocks detachably disposed on the scan tray is provided. The scan tray includes a frame including an opening and a slot, and a transparent substrate covering the opening of the frame. Each of the microarray blocks includes a main body, a probe array distributed on the main body and facing towards the transparent substrate of the scan tray, and a plurality of guiding pins disposed on the main body and surrounding the probe array, wherein a top surface area of the guiding pin opposite to the main body is less than a bottom surface area of the guiding pin connected to the main body, and the guiding pins are detachably inserted into the slot of the frame of the scan tray.Type: GrantFiled: May 31, 2018Date of Patent: February 9, 2021Assignee: Centrillion Technologies Taiwan Co. LTD.Inventors: Wei Zhou, Lin-Hsin Tu, Yao-Kuang Chung, Tzu-Kun Ku, Glenn McGall
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Patent number: 10872924Abstract: A microarray and a method for forming the same are disclosed and the method includes the following steps. A solid matrix and a micro LED array is provided, wherein the solid matrix comprises a plurality of areas corresponding to a plurality of LEDs of the micro LED array. A monomer with a photolabile protecting group is formed in the plurality of areas respectively. At least one of the plurality of areas is irradiated by turning on the corresponding LED of the micro LED array, so as to eliminate the photolabile protecting group of the monomer in the at least one of the plurality of areas. A monomer is conjugated to the deprotected monomer in the at least one of the plurality of areas. The steps of irradiating and conjugating are repeated, so as to form probes in the plurality of areas respectively.Type: GrantFiled: November 27, 2018Date of Patent: December 22, 2020Assignee: Centrillion Technologies Taiwan Co. LTD.Inventors: Tzu-Kun Ku, Yao-Kuang Chung, Chun-Hao Chang
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Patent number: 10852237Abstract: A microarray including a plurality of detection areas and at least one mark is provided. The plurality of the detection areas are arranged in an array. The at least one mark is disposed among or beside the plurality of the detection areas. The at least one mark is configured for at least one of image focusing, positioning and splicing, wherein the at least one mark comprises a plurality of grid dots distributed in an area. The area comprises a plurality of zones arranged in an array, each of the plurality of the grid dots is disposed in one of the plurality of the zones, a number of the plurality of the grid dots is less than a number of the plurality of the zones, and the plurality of the grid dots form a two-dimensional pattern.Type: GrantFiled: March 19, 2019Date of Patent: December 1, 2020Assignee: Centrillion Technologies Taiwan Co., LTD.Inventors: Yao-Kuang Chung, Jui-Hung Hung, Chao-Hsi Lee
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Patent number: 10732166Abstract: A method for in-line measurement of the quality of a microarray are disclosed and the method includes the following steps. A solid substrate is provided, and the solid substrate includes a plurality of areas in an array. At least one biomarker is in-situ synthesized on at least one of the plurality of areas by a plurality of synthesis steps. After performing at least one of the plurality of synthesis step, a check step is immediately performed on a semi-product of the at least one biomarker by an atomic force microscope to obtain an in-line measurement result. The quality of the semi-product of the at least one biomarker is determined based on the in-line measurement result.Type: GrantFiled: February 14, 2018Date of Patent: August 4, 2020Assignee: Centrillion Technologies Taiwan Co. LTD.Inventors: Tzu-Kun Ku, Yao-Kuang Chung, Yu-Chen Wang, Po-Yen Liu
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Publication number: 20190293563Abstract: A microarray including a plurality of detection areas and at least one mark is provided. The plurality of the detection areas are arranged in an array. The at least one mark is disposed among or beside the plurality of the detection areas. The at least one mark is configured for at least one of image focusing, positioning and splicing, wherein the at least one mark comprises a plurality of grid dots distributed in an area. The area comprises a plurality of zones arranged in an array, each of the plurality of the grid dots is disposed in one of the plurality of the zones, a number of the plurality of the grid dots is less than a number of the plurality of the zones, and the plurality of the grid dots form a two-dimensional pattern.Type: ApplicationFiled: March 19, 2019Publication date: September 26, 2019Applicant: Centrillion Technologies Taiwan Co. LTD.Inventors: Yao-Kuang Chung, Jui-Hung Hung, Chao-Hsi Lee
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Publication number: 20190165039Abstract: A microarray and a method for forming the same are disclosed and the method includes the following steps. A solid matrix and a micro LED array is provided, wherein the solid matrix comprises a plurality of areas corresponding to a plurality of LEDs of the micro LED array. A monomer with a photolabile protecting group is formed in the plurality of areas respectively. At least one of the plurality of areas is irradiated by turning on the corresponding LED of the micro LED array, so as to eliminate the photolabile protecting group of the monomer in the at least one of the plurality of areas. A monomer is conjugated to the deprotected monomer in the at least one of the plurality of areas. The steps of irradiating and conjugating are repeated, so as to form probes in the plurality of areas respectively.Type: ApplicationFiled: November 27, 2018Publication date: May 30, 2019Applicant: Centrillion Technologies Taiwan Co. LTD.Inventors: Tzu-Kun Ku, Yao-Kuang Chung, Chun-Hao Chang
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Publication number: 20180345290Abstract: A microarray carrier assembly including a scan tray and a plurality of microarray blocks detachably disposed on the scan tray is provided. The scan tray includes a frame including an opening and a slot, and a transparent substrate covering the opening of the frame. Each of the microarray blocks includes a main body, a probe array distributed on the main body and facing towards the transparent substrate of the scan tray, and a plurality of guiding pins disposed on the main body and surrounding the probe array, wherein a top surface area of the guiding pin opposite to the main body is less than a bottom surface area of the guiding pin connected to the main body, and the guiding pins are detachably inserted into the slot of the frame of the scan tray.Type: ApplicationFiled: May 31, 2018Publication date: December 6, 2018Applicant: Centrillion Technologies Taiwan Co. LTD.Inventors: Wei Zhou, Lin-Hsin Tu, Yao-Kuang Chung, Tzu-Kun Ku, Glenn McGall
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Publication number: 20180238855Abstract: A method for in-line measurement of the quality of a microarray are disclosed and the method includes the following steps. A solid substrate is provided, and the solid substrate includes a plurality of areas in an array. At least one biomarker is in-situ synthesized on at least one of the plurality of areas by a plurality of synthesis steps. After performing at least one of the plurality of synthesis step, a check step is immediately performed on a semi-product of the at least one biomarker by an atomic force microscope to obtain an in-line measurement result. The quality of the semi-product of the at least one biomarker is determined based on the in-line measurement result.Type: ApplicationFiled: February 14, 2018Publication date: August 23, 2018Applicant: Centrillion Technologies Taiwan Co. LTD.Inventors: Tzu-Kun Ku, Yao-Kuang Chung, Yu-Chen Wang, Po-Yen Liu