Abstract: A technique for the analysis of global miRNA signatures including a larger panel of miRNAs in various groups of well-characterized colorectal cancers (CRCs) is described in the instant invention. The results presented herein provide a large list of miRNAs that are dysregulated in CRC compared to the normal colonic tissue, and, more importantly, the present invention shows for the first time that Lynch syndrome and sporadic MSI tumors exhibit a different miRNA signature that distinguishes them.
Type:
Application
Filed:
October 7, 2011
Publication date:
April 12, 2012
Applicants:
Baylor Research Institute, Centro de Investigacion en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), Hospital Clinic de Barcelona
Inventors:
Ajay Goel, C. Richard Boland, Francesc Balaguer, Meritxell Gironella i Cos, Antoni Castells i Garangou, Leticia Moreira Ruiz, Juan Jose Lozano Salvatella