Patents Assigned to Centrose, LLC
  • Extracellular targeted drug conjugates
    Patent number: 10675352
    Abstract: Extracellular drug conjugates (EDCs) targeting CD38 are useful in the treatment of diseases such as cancer and immune disorders, including asthma.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: June 9, 2020
    Assignee: Centrose, LLC
    Inventor: James R. Prudent
  • Extracellular targeted drug conjugates
    Patent number: 9364554
    Abstract: The present invention relates to, inter alia, extracellular drug conjugates (EDC) in which an antibody or other targeting agent (e.g. a targeting moiety) is linked to a drug through a linker (e.g. a non-cleavable linker). These conjugates are useful in the treatment of disease and/or as a tool in the evaluation of biological systems.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: June 14, 2016
    Assignee: Centrose LLC
    Inventors: Charles R. Hutchinson, James R. Prudent, Jon S. Thorson
  • EXTRACELLULAR TARGETED DRUG CONJUGATES
    Publication number: 20140193436
    Abstract: Extracellular-targeted drug conjugates (EDC) in which a targeting moiety targeting a protein associated with the Na,K-ATPase is linked to a drug that interacts with the Na,K-ATPase through a linker a stable linker are useful in the treatment of disease and as tools for the evaluation of biological systems.
    Type: Application
    Filed: June 25, 2012
    Publication date: July 10, 2014
    Applicant: CENTROSE, LLC
    Inventor: James R. Prudent
  • Glycoside compounds and pharmaceutical compositions thereof
    Patent number: 8703723
    Abstract: The present invention provides glycoside compounds, methods of preparing such compounds, pharmaceutical compositions comprising such compounds, and a method for the treatment of hyperproliferative diseases using the same.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: April 22, 2014
    Assignee: Centrose, LLC
    Inventor: Jill Hutchinson-Bollettieri
  • EXTRACELLULAR TARGETED DRUG CONJUGATES
    Publication number: 20140079722
    Abstract: Antibodies targeting the dysadherin subunit of the human Na,K-ATPase signaling complex that are covalently linked via a stable linker to steroid drugs that bind the alpha subunit of that complex are useful in the treatment of cancer.
    Type: Application
    Filed: March 9, 2012
    Publication date: March 20, 2014
    Applicant: CENTROSE, LLC
    Inventor: James R. Prudent
  • EXTRACELLULAR TARGETED DRUG CONJUGATES
    Publication number: 20130336994
    Abstract: The present invention relates to, inter alia, extracellular drug conjugates (EDC) in which an antibody or other targeting agent (e.g. a targeting moiety) is linked to a drug through a linker (e.g. a non-cleavable linker). These conjugates are useful in the treatment of disease and/or as a tool in the evaluation of biological systems.
    Type: Application
    Filed: May 20, 2013
    Publication date: December 19, 2013
    Applicant: CENTROSE, LLC
    Inventors: Charles R. Hutchinson, James R. Prudent, Jon S. Thorson
  • GLYCOSIDE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20130178431
    Abstract: The present invention provides glycoside compounds, methods of preparing such compounds, pharmaceutical compositions comprising such compounds, and a method for the treatment of hyperproliferative diseases using the same.
    Type: Application
    Filed: December 27, 2012
    Publication date: July 11, 2013
    Applicants: CENTROSE, LLC
    Inventor: Jill Hutchinson-Bollettieri
  • Extracellular targeted drug conjugates
    Patent number: 8470980
    Abstract: The present invention relates to, inter alia, extracellular drug conjugates (EDC) in which an antibody or other targeting agent (e.g. a targeting moiety) is linked to a drug through a linker (e.g. a non-cleavable linker). These conjugates are useful in the treatment of disease and/or as a tool in the evaluation of biological systems.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: June 25, 2013
    Assignee: Centrose, LLC
    Inventors: James R. Prudent, Jon S. Thorson, Jill Hutchinson Bollettieri
  • Glycoside compounds and pharmaceutical compositions thereof
    Patent number: 8361973
    Abstract: The present invention provides glycoside compounds, methods of preparing such compounds, pharmaceutical compositions comprising such compounds, and a method for the treatment of hyperproliferative diseases using the same.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: January 29, 2013
    Assignee: Centrose, LLC
    Inventors: Mohammed S. Shekhani, James R. Prudent, Jill Hutchinson Bollettieri
  • GLYCOSIDE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20110319350
    Abstract: The present invention provides glycoside compounds, methods of preparing such compounds, pharmaceutical compositions comprising such compounds, and a method for the treatment of hyperproliferative diseases using the same.
    Type: Application
    Filed: August 7, 2009
    Publication date: December 29, 2011
    Applicant: CENTROSE, LLC
    Inventors: Charles R. Hutchinson, Mohammed S. Shekhani, James R. Prudent
  • EXTRACELLULAR TARGETED DRUG CONJUGATES
    Publication number: 20110064752
    Abstract: The present invention relates to, inter alia, extracellular drug conjugates (EDC) in which an antibody or other targeting agent (e.g. a targeting moiety) is linked to a drug through a linker (e.g. a non-cleavable linker). These conjugates are useful in the treatment of disease and/or as a tool in the evaluation of biological systems.
    Type: Application
    Filed: September 9, 2010
    Publication date: March 17, 2011
    Applicant: CENTROSE, LLC
    Inventors: Charles R. Hutchinson, Jill Hutchinson Bollettieri, James R. Prudent, Jon S. Thorson