Patents Assigned to CENTRUM MEDYCZNE KSZTALCENIA PODYPLOMOWEGO
  • Hybrid cholinesterase inhibitors
    Patent number: 8841453
    Abstract: The invention relates to novel hybrid cholinesterase inhibitors containing the melatonin or its oxidation products unit and tetrahydroacridine unit linked via a carbamate bond. Due to the high selectivity of action, which is expressed with high ratio of IC50 for acetylcholinesterase inhibition to IC50 for butyrylcholinesterase inhibition ([IC50(AChE)]/[IC50(BChE)]), the novel compounds may be used in relief and/or treatment of the neurodegenerative diseases, among them the Alzheimer's disease.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: September 23, 2014
    Assignees: Uniwersytet Warszawski, Centrum Medyczne Ksztalcenia Podyplomowego
    Inventors: Anna Zawadzka, Zbigniew Czarnocki, Iwona Lozinska, Zuzanna Moleda, Miroslawa Panasiewicz
  • NOVEL HYBRID CHOLINESTERASE INHIBITORS
    Publication number: 20140080860
    Abstract: The invention relates to novel hybrid cholinesterase inhibitors containing the melatonin or its oxidation products unit and tetrahydroacridine unit linked via a carbamate bond. Due to the high selectivity of action, which is expressed with high ratio of IC50 for acetylcholinesterase inhibition to IC50 for butyrylcholinesterase inhibition ([IC50(AChE)]/[IC50(BChE)]), the novel compounds may be used in relief and/or treatment of the neurodegenerative diseases, among them the Alzheimer's disease.
    Type: Application
    Filed: November 22, 2013
    Publication date: March 20, 2014
    Applicants: CENTRUM MEDYCZNE KSZTALCENIA PODYPLOMOWEGO, UNIWERSYTET WARSZAWSKI
    Inventors: Anna Zawadzka, Zbigniew Czarnocki, Iwona Lozinska, Zuzanna Moleda, Miroslawa Panasiewicz