Abstract: A composition for treating impotence contains a vasodilator, a vasoconstrictor, and a penetration enhancing ingredient in a pharmaceutically acceptable carrier for topical application. The composition is applied topically to treat impotence.

Abstract: Free fatty acids from fish oils, DHA and EPA, are useful in treating diabetes mellitus. The free fatty acids were an order of magnitude more effective in treating diabetes than unhydrolyzed fatty acids derived from fish oil.

Abstract: An infant food formulation substantially approximating human milk in fatty acid composition comprising a mixture of DHA and EPA in a ratio of approximately 3:2 by weight, immunoglobulins to mimic the immunoglobulin content of mother's milk, a source of protein, a source of carbohydrate, a source of ash, and sufficient water to provide an easily assimilable infant formula, the DHA, the EPA, and the immunoglobulins being encapsulated in capsules having a diameter of less than 350.mu..

Abstract: Marine animal oil free of undesirable odor or taste is produced by treating a freshly killed marine animal with a peroxidase-inhibiting antioxidant, disaggregating the marine animal, separating the oil phase, mixing with a dilute aqueous acidic solution, removing the oil phase and adding antioxidant. Marine animal oil which has already turned rancid may be restored to a non-rancid state by mixing with a reducing antioxidant such as a thiodipropionate, separating out the fatty acids which have reacted with the antioxidant, preferably by column chromatography, and adding another antioxidant to prevent further peroxidation.

Abstract: A process for obtaining fish meal which is essentially free of oil, as well as recovering valuable free polyunsaturated fatty acids, comprising hydrolyzing membrane phospholipids in comminuted fish with aqueous alkali solution, at a temperature which is not substantially above ambient, adding a strong acid to release free polyunsaturated fatty acids, recovering the free fatty acids from the aqueous phase by mechanical separation, and drying the aqueous phase.

Abstract: Saturated aliphatic straight chain dicarboxylic acids having a total number of carbon atoms which are divisible by four, are selectively toxic to certain tumor cells while non-toxic to normal cells of the same origin. Octacosanedioic acid is particularly preferred as it is a component of normal blood serum. Compositions containing these compounds may be used in the treatment of certain malignancies.

Abstract: Free fatty acids form fish oil, DHA and EPA, are useful in treating rheumatoid arthritis. The free fatty acids were an order of magnitude more effective in treating arthritis than unhydrolyzed fatty acids derived from fish oil.

Abstract: To extract and purify of polyunsaturated fatty acids, particularly EPA and DHA, without cis-trans conversion, from naturally occurring oils, such as marine animal oil and various vegetable oils a mixture of free fatty acids is first extracted from the oil. The resulting mixture of pure fatty acids is then subjected to separation by means of urea complexing to remove saturated fatty acids and most mono-unsaturated fatty acids. Remaining solvent and urea are then removed from the filtrate which is then subjected to low temperature fractional crystallization in the presence of an organic solvent such as acetone. Substantially pure polyunsaturated fatty acids, especially EPA and DHA, can be separately precipitated by reducing the temperature of the filtrate in two steps. Alternatively, the volume of the filtrate is reduced in two steps and cooled to form precipitates, which are removed. The final product is a mixture of substantially pure DHA and EPA.

Abstract: Treatment of prophylaxis of thrombo-embolic conditions is obtained through the simultaneous administration of eicosapentaenoic acid and/or docosahexaenoic acid together with one or more of linoleic acid, .gamma.-linolenic acid and dihomo-.gamma.-linolenic acid, either in the form of a pharmaceutical dosage or in the form of a food product such as margarine or cooking oil.