Patents Assigned to CENTURY THERAPEUTICS, INC.
  • Chimeric antigen receptor system with adaptable receptor specificity
    Patent number: 11883432
    Abstract: The present disclosure provides chimeric antigen receptors (CARs), particularly CARs that have adaptable receptor specificity (arCARs). Also provided are polypeptides of the CARs and other related molecules, polynucleotides, vectors, and cell compositions comprising the same. Pharmaceutical compositions comprising the polypeptides, polynucleotides, vectors, or cells of the present disclosure, and their uses in treating a disease in a subject are also provided.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: January 30, 2024
    Assignee: CENTURY THERAPEUTICS, INC.
    Inventors: Jill Marinari Carton, Michael Francis Naso, Luis Ghira Borges, John Wheeler, Andrew Devaney
  • METHODS FOR CONTROLLED ACTIVATION AND/OR EXPANSION OF GENETICALLY ENGINEERED CELLS USING POLYETHYLENE GLYCOL (PEG) RECEPTORS
    Publication number: 20230381317
    Abstract: Provided are genetically engineered induced pluripotent stem cells (iPSCs) and derivative cells thereof expressing a polyethylene glycol (PEG) receptors and methods of using the same. Also provided are compositions, polypeptides, vectors, and methods of manufacturing.
    Type: Application
    Filed: April 20, 2023
    Publication date: November 30, 2023
    Applicant: Century Therapeutics, Inc.
    Inventors: Hyam Levitsky, Andreia Costa, John Wheeler, Melissa Chiasson, Eric Eymard, Rupesh Amin
  • Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
    Patent number: 11661459
    Abstract: Provided are polynucleotides encoding inactivated cell surface receptors. Also provided are genetically engineered induced pluripotent stem cells (iPSCs) and derivative cells thereof expressing a chimeric antigen receptor (CAR) and methods of using the same. Also provided are compositions, polypeptides, vectors, and methods of manufacturing.
    Type: Grant
    Filed: December 1, 2021
    Date of Patent: May 30, 2023
    Assignee: Century Therapeutics, Inc.
    Inventors: Michael Naso, Jill Carton, John Wheeler, Luis Borges
  • GENE TRANSFER VECTORS AND METHODS OF ENGINEERING CELLS
    Publication number: 20220331361
    Abstract: The present disclosure provides compositions and methods for use in genome engineering of induced pluripotent stem cells (iPSCs). Specifically, the methods and compositions described are useful for introducing transgenes into iPSCs such as pluripotent hematopoietic stem cells and/or progenitor cells (HSC/PC) using an CRISPR nuclease-based system (e.g., MAD7 nuclease-based system) and preparing immune-effector cells derived from the iPSCs.
    Type: Application
    Filed: April 6, 2022
    Publication date: October 20, 2022
    Applicant: CENTURY THERAPEUTICS, INC.
    Inventors: Michael Francis NASO, Buddha GURUNG, Jill Marinari CARTON, John WHEELER, Luis Ghira BORGES
  • CHIMERIC ANTIGEN RECEPTOR SYSTEM WITH ADAPTABLE RECEPTOR SPECIFICITY
    Publication number: 20220193133
    Abstract: The present disclosure provides chimeric antigen receptors (CARs), particularly CARs that have adaptable receptor specificity (arCARs). Also provided are polypeptides of the CARs and other related molecules, polynucleotides, vectors, and cell compositions comprising the same. Pharmaceutical compositions comprising the polypeptides, polynucleotides, vectors, or cells of the present disclosure, and their uses in treating a disease in a subject are also provided.
    Type: Application
    Filed: December 17, 2021
    Publication date: June 23, 2022
    Applicant: CENTURY THERAPEUTICS, INC.
    Inventors: Jill Marinari CARTON, Michael Francis NASO, Luis Ghira BORGES, John WHEELER, Andrew DEVANEY
  • Small molecules and methods of reducing injuries caused by radiation or chemicals
    Patent number: 11236056
    Abstract: A series of small molecule, radioprotective agents based on a compound of the general formula (I): or pharmaceutically acceptable salts thereof, wherein n is 1 or 2, and, independently, R is Br, Cl, H—O, H3C—S, and use of the compounds to protect healthy tissue/organs of subjects to reduce the injuries caused by radiation or chemicals.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: February 1, 2022
    Assignee: 21ST CENTURY THERAPEUTICS, INC.
    Inventor: Jiajiu Shaw
  • SMALL MOLECULES AND METHODS OF REDUCING INJURIES CAUSED BY RADIATION OR CHEMICALS
    Publication number: 20210087153
    Abstract: A series of small molecule, radioprotective agents based on a compound of the general formula (I): or pharmaceutically acceptable salts thereof, wherein n is 1 or 2, and, independently, R is Br, Cl, H—O, H3C—S, and use of the compounds to protect healthy tissue/organs of subjects to reduce the injuries caused by radiation or chemicals.
    Type: Application
    Filed: August 13, 2020
    Publication date: March 25, 2021
    Applicant: 21st Century Therapeutics, Inc
    Inventor: Jiajiu SHAW
  • Small-molecule TNF modulator to reduce the side effects of chemotherapy and radiotherapy
    Publication number: 20120082736
    Abstract: Cancer patients treated by chemotherapy and/or radiotherapy often suffer serious side effects. Currently, there is only one FDA approved and used as both a chemoprotector and a radioprotector, amifostine, which is associated with significant problems. Disclosed in the present invention are novel methods of using UTL-5g as both a chemoprotector and radioprotector for treating cancer patients in addition to other related methods.
    Type: Application
    Filed: September 25, 2011
    Publication date: April 5, 2012
    Applicants: GeneBlue Corporation, 21st Century Therapeutics, Inc.
    Inventor: Jiajiu SHAW