Abstract: The device is intended for neutralizing a residual-pressure valve, without the need to remove it, for the purpose of filling the bottle. The device comprises a tubular housing (12) designed to be fastened, in the operative position, to a connection piece (2) of the bottle sealingly and comprising at least one first lateral connector (44) for connection to a gas source, a gripper (20) seated axially in the housing (12) and stressed by a spring (38) so as, in the operative position, to penetrate into the connection piece (2) round the rod (8) of the closing member (6), and an actuator for displacing the gripper (20) axially counter to the action of the spring (38) and for simultaneously closing it so as to drive the rod (8) and lift the closing member (6) from its seat.