Abstract: In certain aspects, the present disclosure relates to novel radiopharmaceutical ketone molecules, including acetoacetate (AcAc) and/or beta-hydroxybutyrate (BHB), and methods of using one or more radiopharmaceutical ketone molecules or radiopharmaceutical compositions as imaging agents or tracers in positron emission tomography (PET) or combination PET and magnetic resonance imaging (MRI), e.g., as ketone-PET tracers. The methods may be used in diagnostic imaging methodologies in Alzheimer's disease, cognitive impairment, and other conditions of altered cerebral metabolism.
Type:
Application
Filed:
November 17, 2021
Publication date:
January 18, 2024
Applicant:
Cerecin Inc.
Inventors:
Ernest Wong, Judith Walker, Samuel T. Henderson
Abstract: The invention relates compositions of medium chain triglycerides (MCTs), and to methods for treatment with such compositions to treat conditions associated with reduced neuronal metabolism, for example Alzheimer's disease.
Type:
Application
Filed:
October 11, 2021
Publication date:
November 23, 2023
Applicant:
Cerecin Inc.
Inventors:
Judith Anne Walker, Samuel T . Henderson, Bruce H. Morimoto
Abstract: This invention relates to high drug load compositions of medium chain triglycerides (MCT), and to methods for treatment with such compositions at amounts effective to elevate ketone body concentrations so as to treat conditions associated with reduced neuronal metabolism, for example Alzheimer’s disease.
Type:
Application
Filed:
January 19, 2023
Publication date:
September 7, 2023
Applicant:
CERECIN INC.
Inventors:
Aaron M. Badenoch, Taryn Boivin, Devon B. DuBose, Samuel T. Henderson, Christi Lynn Hostetler, David K. Lyon, Craig A. Sather, Matthew J. Shaffer
Abstract: The present disclosure relates to methods for the treatment of Infantile Spasms and/or the prevention of spasms of Infantile spasms. The methods include administering compositions comprising at least one compound capable of elevating ketone body concentrations in a subject in need thereof (e.g., ketogenic compounds), administered in an amount effective for treatment of Infantile Spasms and or the prevention of spams of Infantile Spasms. In one embodiment, the composition includes medium chain triglycerides (MCT). The composition may be administered as an oral dosage forms, in particular, a nutritional drink comprising at least one compound capable of elevating ketone body concentrations in a subject.
Abstract: This invention relates to high drug load compositions of medium chain triglycerides (MCT), and to methods for treatment with such compositions at amounts effective to elevate ketone body concentrations so as to treat conditions associated with reduced neuronal metabolism, for example Alzheimer's disease.
Type:
Grant
Filed:
March 15, 2018
Date of Patent:
January 24, 2023
Assignee:
Cerecin Inc.
Inventors:
Aaron M. Badenoch, Taryn Boivin, Devon B. DuBose, Samuel T. Henderson, Christi Lynn Hostetler, David K. Lyon, Craig A. Sather, Matthew J. Shaffer
Abstract: The invention relates compositions of medium chain triglycerides (MCTs), and to methods for treatment with such compositions to treat conditions associated with reduced neuronal metabolism, for example Alzheimer's disease.
Type:
Application
Filed:
March 4, 2020
Publication date:
April 28, 2022
Applicant:
Cerecin Inc.
Inventors:
Samuel T. Henderson, Taryn Boivin, Judith Walker