Patents Assigned to Cerep SA
  • Pyrrolizine compounds useful as anti-inflammatory agents
    Patent number: 7375237
    Abstract: Pyrrolizine compounds having the formula (I), or pharmaceutically-acceptable salts thereof, are effective in treating inflammatory or immune diseases, where A is a four- to seven-membered saturated ring, K is O or S, and R1, R2, R3 n, and M are defined in the specification.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: May 20, 2008
    Assignees: Bristol-Myers Squibb Company, Cerep SA
    Inventors: T. G. Murali Dhar, Dharmpal S. Dodd, Dominique Potin, Michele Launay
  • Spiro-cyclic compounds useful as anti-inflammatory agents
    Patent number: 7199125
    Abstract: The present invention is directed to compounds having the formula (I): useful in treating inflammatory and immune diseases, in which K and L are independently, O or S; Q is —C(?O)— or optionally substituted C1-6alkylene; Ar is optionally-substituted aryl or heteroaryl; J1, J2, J3 and Y are selected so that ring A is a five-to-six membered optionally-substituted cycloalkenyl or heterocyclo ring having 0 to 2 nitrogen heteroatoms; R1 is N or C(R9); and R2, and R3, are as defined in the specification.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: April 3, 2007
    Assignees: Bristol-Myers Squibb Company, Cerep SA
    Inventors: T. G. Murali Dhar, Edwin Iwanowicz, Michele Launay, Dominique Potin, Magali Jeannine Blandine Maillet, Eric Nicolai
  • Spiro-hydantoin compounds useful as anti-inflammatory agents
    Patent number: 7078420
    Abstract: Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L and K are O or S; Z is N or CR4b; Ar is an optionally-substituted aryl or heteroaryl; G is a linker attached to T or M or is absent; J, M and T are selected to define a three to six membered saturated or partially unsaturated non-aromatic ring; and R2, R4a, R4b, and R4c are as defined in the specification.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: July 18, 2006
    Assignees: Bristol-Myers Squibb Company, Cerep SA
    Inventors: T. G. Murali Dhar, Dominique Potin, Magali Jeannine Blandine Maillet, Michele Launay, Eric Antoine Nicolai, Edwin J. Iwanowicz
  • Spiro-hydantoin compounds useful as anti-inflammatory agents
    Patent number: 6977267
    Abstract: Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L and K are O or S; Z is N or CR4b; Ar is an optionally-substituted aryl or heteroaryl; G is a linker attached to T or M or is absent; J, M and T are selected to define a three to six membered saturated or partially unsaturated non-aromatic ring; and R2,R4a, R4b, and R4c are as defined in the specification.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: December 20, 2005
    Assignees: Bristol-Myers Squibb Company, CEREP SA
    Inventors: T. G. Murali Dhar, Dominique Potin, Magali Jeannine Blandine Maillet, Michele Launay, Eric Antoine Nicolai, Edwin J. Iwanowicz
  • Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents
    Patent number: 6974815
    Abstract: The present invention is directed to compounds having the formula (I): useful in treating inflammatory and immune diseases, in which K is O or S; Q is —C(?O)— or optionally substituted C1-4alkylene; Ar is optionally-substituted aryl or heteroaryl; J1, J2, J3, and Y are selected so that ring A is a five-to-six membered optionally-substituted cycloalkenyl or heterocyclo ring having 0 to 2 nitrogen heteroatoms; Z is N or C(R9); and R1, R2, R3 and R9 are as defined in the specification.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: December 13, 2005
    Assignees: Bristol-Myers Squibb Company, Cerep SA
    Inventors: T G. Murali Dhar, Dominique Potin, Magali Jeannine Blandine Maillet, Michele Launay, Eric Antoine Nicolai, Edwin J. Iwanowicz
  • Urazole compounds useful as anti-inflammatory agents
    Patent number: 6673825
    Abstract: Urazole compounds having the formula (I), or pharmaceutically-acceptable salts thereof, are effective as anti-inflammatory or immunosuppressive agents, wherein L and K are O or S; Q is a linker such as —O—, —S—, C(═O), and so forth, R1 is an aryl or heteroaryl group, and R3, R4a, R4c, Z, r, s and t are as defined in the specification.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: January 6, 2004
    Assignees: Bristol-Myers Squibb Co., Cerep SA
    Inventors: Michele Launay, Dominique Potin, Magali Jeannine Blandine Maillet, Eric Antoine Nicolai, Edwin J. Iwanowicz, T. G. Murali Dhar