Abstract: A remote medical assessment and therapy management apparatus comprising a center user interface, a center computer coupleable with the center user interface. The center computer displays information via the center user interface for use in developing a therapeutic prescription and receives therapeutic control inputs from a user. A remote device includes a medical diagnostic instrument for acquiring biophysical data from a patient, a medical therapeutic instrument that provides a therapy to the patient, and a remote computer that receives diagnostic signals from the diagnostic instrument and transmits therapeutic control signals to the therapeutic instrument. A network interface is connected between the first center computer and the remote computer and transmits diagnostic signals from the remote computer to the center computer and control signals from the center computer to the therapeutic instrument via the remote computer.

Abstract: A tissue stimulation system that generates an electrical tissue stimulation signal configured to reduce tissue impedance and increase depth of signal penetration. The use of leads is dynamically controlled and altered between conducting biopotential voltages, conducting electrical tissue stimulation signals, and grounding, in response to a computational analysis of biopotential data acquired from a region of tissue to be stimulated.

Abstract: A tissue stimulation system that generates an electrical tissue stimulation signal configured to reduce tissue impedance and increase depth of signal penetration. The use of leads is dynamically controlled and altered between conducting biopotential voltages, conducting electrical tissue stimulation signals, and grounding, in response to a computational analysis of biopotential data acquired from a region of tissue to be stimulated.

Abstract: A computing device-controlled system is described for the generation of amplitude-modulated pulse-width modulation (AMPWM) signals for use in treating neurological dysfunction via cranial neurostimulation, where the AMPWM signal is specifically designed to minimize the electrical impedance of the tissues of the head. A low-frequency carrier signal is determined for the AMPWM signal by measuring EEG activity at a reference site or sites, generally corresponding with the location of suspected brain dysfunction. Carrier signal frequency is variably related to critical frequency components of the EEG power spectral density, determined from statistical analysis of amplitudes and variability, and dynamically changed as a function of time to prevent entrainment. The AMPWM signal is presented to a subject via a plurality of neurostimulation delivery modes for therapeutic use.

Abstract: Methods are disclosed for stimulating targeted regions of a brain to alleviate symptoms, treat conditions and/or modify brain activities associated with central sensitivity in a subject. The methods may include selecting a subject suffering from central sensitivity, identifying regions of the brain involved in central sensitivity, and stimulating one or more of these regions of the brain.

Abstract: A method for diagnosing and assessing a brain-related chronic pain disorder. The method includes assessing a subject's brain function, determining the probability that a subject is suffering from chronic pain as a result of an abnormal brain function condition by obtaining a quantitative assessment of the subject's brain function, and making a statistical comparison between the subject's quantitative brain function assessment and either a database of quantitative assessments of the brain functions of normal, healthy individuals, or a database of quantitative assessments of the brain functions of individuals known to have been suffering from chronic pain as a result of the abnormal brain function condition.

Abstract: A computing device-controlled system is described for the generation of amplitude-modulated pulse-width modulation (AMPWM) signals for use in treating neurological dysfunction via cranial neurostimulation, where the AMPWM signal is specifically designed to minimize the electrical impedance of the tissues of the head. A low-frequency carrier signal is determined for the AMPWM signal by measuring EEG activity at a reference site or sites, generally corresponding with the location of suspected brain dysfunction. Carrier signal frequency is variably related to critical frequency components of the EEG power spectral density, determined from statistical analysis of amplitudes and variability, and dynamically changed as a function of time to prevent entrainment. The AMPWM signal is presented to a subject via a plurality of neurostimulation delivery modes for therapeutic use.

Abstract: A computing device-controlled system is described for the generation of amplitude-modulated pulse-width modulation (AMPWM) signals for use in treating neurological dysfunction via cranial neurostimulation, where the AMPWM signal is specifically designed to minimize the electrical impedance of the tissues of the head. A low-frequency carrier signal is determined for the AMPWM signal by measuring EEG activity at a reference site or sites, generally corresponding with the location of suspected brain dysfunction. Carrier signal frequency is variably related to critical frequency components of the EEG power spectral density, determined from statistical analysis of amplitudes and variability, and dynamically changed as a function of time to prevent entrainment. The AMPWM signal is presented to a subject via a plurality of neurostimulation delivery modes for therapeutic use.