Patents Assigned to Ceskoslovenska Akademie Ved
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Patent number: 5486596Abstract: Analogues of 8-D-homoarginine vasopressin were prepared with the general formula ##STR1## where X is L-O-methyltyrosine, L-p-ethylphenylalanine, D-p-ethylphenylalanine, L-p-methylphenylalanine or D-methylphenylalanine and R is cysteine or .beta.-mercaptopropionic acid. These vasopressin analogues exhibited an increased affinity to uterus receptors for oxytocin, where they acted as ocytocin antagonists. Moreover, the analogues of deamino vasopressin have a significantly reduced antidiuretic activity in comparison with [8-D-arginine]vasopressin.Type: GrantFiled: August 25, 1993Date of Patent: January 23, 1996Assignee: Ceskoslovenska akademie vedInventors: Zdenko Prochazka, Ivo Blaha, Miroslava Zertova, Jirina Slaninova, Jiri Velek, Jana Skopkova, Michal Lebl, Tomislav Barth, Lenka Maletinska, Hans Vilhardt
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Patent number: 5391669Abstract: A water swellable crosslinked polymer of essentially balanced charge is obtained by polymerizing a polymer-forming composition comprising a cationic-anionic pair of ethylenically unsaturated monomers and a non-ionic ethylenically unsaturated hydrophilic and/or hydrophobic monomer. Contact lenses formed from the polymer exhibit little if any tendency to attract soils, e.g., proteinaceous debris, to their surfaces.Type: GrantFiled: November 9, 1993Date of Patent: February 21, 1995Assignees: Hydron Limited, Ceskoslovenska akademie ved.Inventors: Jiri Sulc, Zuzana Krcova, Patrick Chen, Qi-Bin Bao
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Patent number: 5384370Abstract: The present invention concerns rubber-based composite materials swellable with water and associated methods of production. A swellable rubber material according to the present invention comprises a vulcanized non-silicone rubber selected from the group consisting of natural rubber, butadiene-styrene rubber, bromobutyl rubber, and ethylene-propylene rubber; and a hydrogel filler cross-linked by a crosslinking agent, wherein the composite material is vulcanizable at a temperature up to 150.degree. C., is thermoformable, possesses shape memory after thermoforming, and is swellable with water or aqueous solutions.Type: GrantFiled: January 31, 1994Date of Patent: January 24, 1995Assignee: Ceskoslovenska akademie vedInventors: Petr Vondracek, Petr Lopour, Jiri Sulc
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Patent number: 5338831Abstract: A method is disclosed for performing a multiple synthesis of peptides on a solid carrier. Active components are successively bonded to functional groups anchored on a carrier. The carrier is a planar porous material divided into functionalized compartments, into which an active component is put, via a dispensing head.Type: GrantFiled: December 14, 1992Date of Patent: August 16, 1994Assignee: Academy of Sciences of the Czech Republic changed from Ceskoslovenska akademie vedInventors: Michal Lebl, Jutta Eichler, Vit Pokorny, Jifi Jehnicka, Petr Mudra, Karel Zenisek, Alena Stierandova, Jan Kalousek, Jan Bolf
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Patent number: 5270415Abstract: A water swellable crosslinked polymer of essentially balanced charge is obtained by polymerizing a polymer-forming composition comprising a cationic-anionic pair of ethylenically unsaturated monomers and a nonionic ethylenically unsaturated hydrophilic and/or hydrophobic monomer. Contact lenses formed from the polymer exhibit little if any tendency to attract soils, e.g., proteinaceous debris, to their surfaces.Type: GrantFiled: December 21, 1990Date of Patent: December 14, 1993Assignees: Allergan Inc., Ceskoslovenska akademie vedInventors: Jiri Sulc, Zuzana Krcova, Patrick Chen, Qi-Bin Bao
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Patent number: 5268081Abstract: An electrolyzer is formed by electrolytic cells, electrically connected in serious. Each cell is provided with inlets and outlets for filling with electrolyte into which dip the positive oxygen electrode and negative pressurized hydrogen electrode with an inner outlet of hydrogen. The hydrogen electrodes are formed by at least one inner layer, by covering layer and by the metallic coating. Said inner layers have the value of hydrogen overvoltage at the highest 0.25 V, said covering layer has the hydrogen overvoltage between 0.3 and 0.4 V and said metallic coating has the hydrogen overvoltage between 0.5 and 1.5 V. The hydrogen electrodes, formed as non-polarizable reversible systems are connected through their inner hydrogen outlets with the inlet of the hydrogen receptacle on condition given byV.sub.O <1/2V.sub.HwhereV.sub.O is the volume of the part of the electrolyte reservoir which is filled with oxygenV.sub.H is the volume of the hydrogen receptaclewhere by the oxygen electrodes are polarizable.Type: GrantFiled: August 4, 1992Date of Patent: December 7, 1993Assignee: Ceskoslovenska Akademie VedInventor: Frantisek Dousek
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Patent number: 5202418Abstract: The invention relates to a method and apparatus for performing a multiple synthesis of peptides on a solid carrier. Active components are successively bonded to functional groups anchored on a carrier. The carrier planar functionalized porous material divided into compartments, into which the needed activated component is put. Common operations of the synthesis are carried out by all compartments of the carrier at the same time.Type: GrantFiled: January 24, 1991Date of Patent: April 13, 1993Assignee: Ceskoslovenska akademie vedInventors: Michal Lebl, Jutta Eichler, Vit Pokorny, Jiri Jehnicka, Petr Mudra, Karel Zenisek, Alena Stierandova, Jan Kalousek, Jan Bolf
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Patent number: 5158832Abstract: A lens made from a non-hydrophilic acrylate or methacrylate polymer or copolymer for application in an aqueous medium inside a human eye or on its surface, i.e., an intraocular or contact lens, is provided wherein the originally non-hydrophilic surface layer has been hydrophilized by a partial hydrolysis or sulfonation in such a way that a gradient of swelling results such that the swelling decreases from a maximum on the very surface to a minimum in the non-swelling core, which is unaffected by hydrophilization. Accordingly, light reflexes are eliminated or at least substantially reduced as well as the tendency of the surface to grow cells, the irritation of neighboring living tissues, and the formation of pressure necroses.Type: GrantFiled: December 7, 1989Date of Patent: October 27, 1992Assignee: Ceskoslovenska akademie vedInventors: Jiri Sulc, Zuzana Krcova
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Patent number: 5142051Abstract: This invention relates to new nucleotide analogues and solves the technical problem of their use as biologically active compounds. The subject of this invention are N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases, easily accessible from heterocyclic bases andd their N-(2-hydroxyethyl) or N-(2,3-dihydroxypropyl) derivatives. Some of the compounds, according to this invention, exhibit a marked antiviral activity or can be converted into such active compounds by chemical transformations.Type: GrantFiled: July 17, 1987Date of Patent: August 25, 1992Assignees: Ceskoslovenska Akademie Ved, Rega InstitutInventors: Antonin Holy, Ivan Rosenberg, Erik D. A. De Clercq
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Patent number: 5130427Abstract: The invention relates to the new compound (2R)-2-[di(2-propyl)phosphonylmethoxy]-3-p-toluenesulfonyloxy-1-trimethyla cetoxypropane and the method of producing it. The compound may be used for producing (S)-N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of the heterocyclic purine and pyrimidine bases of antiviral activity.Type: GrantFiled: July 12, 1991Date of Patent: July 14, 1992Assignee: Ceskoslovenska akademie vedInventors: Petr Alexander, Antonin Holy, Hana Dvorakova
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Patent number: 5130479Abstract: The solution pertains to hydrolytically degradable hydrophilic gels consisting of the individual chains of hydrophilic polymer interconnected with crosslinks containing the structure unit ##STR1## The method for preparation of the hydrolytically degradable gels consists in subjecting hydrophilic monomers or their mixture to the radical polymerization or copolymerization, or to copolymerization with hydrophobic monomers, in the presence of a new compound--N,O-dimethacryloylhydroxylamine--as a crosslinking agent, and, if desired, in the presence of a solvent, whereas the amount of hydrophilic monomers is 50 to 99.8 molar percent related to all monomers present.Type: GrantFiled: December 10, 1991Date of Patent: July 14, 1992Assignee: Ceskoslovenska Akademie VedInventors: Karel Ulbrich, Vladimir Subr
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Patent number: 5125976Abstract: A method for milling Portland clinker for the production of gypsumless Portland cements is provided. The method comprises milling the Portland clinker in the presence of 0.01 to 0.05 weight % of a synthetic, organic, surface-active substance with wetting properties that is stable in an alkaline medium of pH 9-12, with the exception of the triethanolamide of dodecylbenzylsulphonic acid, to produce gypsumless Portland cements with specific surfaces of 350-750 m.sup.2 /kg.Type: GrantFiled: March 30, 1990Date of Patent: June 30, 1992Assignee: Ceskoslovenska Akademie VedInventors: Frantisek Skvara, Jaroslav Hrazdira, Tomas Vsetecka
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Patent number: 5124421Abstract: The solution pertains to hydrolytically degradable hydrophilic gels consisting of the individual chains of hydrophilic polymer interconnected with crosslinks containing the structure ##STR1## The method for preparation of the hydrolytically degradable gels consists in subjecting hydrophilic monomers or their mixture to the radical polymerization or copolymerization, or to copolymerization with hydrophobic monomers, in the presence of a new compound--N,O-dimethacryloylhydroxylamine--as a crosslinking agent, and, if desired, in the presence of a solvent, whereas the amount of hydrophilic monomers is 50 to 99.8 molar percent related to all monomers present.Type: GrantFiled: December 19, 1990Date of Patent: June 23, 1992Assignee: Ceskoslovenska Akademie VedInventors: Karel Ulbrich, Vladnir Subr
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Patent number: 5096930Abstract: This invention relates to a treatment for the improvement of regeneration of injured striated muscles, the key-feature of which is the application of n-butylamine, in natural or ionic form or in buffered solution, as effective substance.Type: GrantFiled: November 15, 1989Date of Patent: March 17, 1992Assignee: Ceskoslovenska akademie vedInventors: Jan Zenka, Dagmar Hulinska, Radim Holusa, Theodor Pokorny, Alexandr Jegorov
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Patent number: 5080683Abstract: A method for the formation of hydrophilic layers on the surface of objects comprised of polymeric esters, nitriles, or combinations thereof, derived from acrylic acid, methacrylic acid, or both, by means of hydrolysis caused by strong acid at elevated temperatures, wherein the solubility of the polymer in warm acid is reduced by the addition of a salt which does not react with said polymer. Preferably, the salt is a salt of the strong acid employed to hydrolyze the polymer. The thickness of the hydrophilic layer may be controlled through control of the concentration of the salt. Optionally, the surface layer containing hydroxyl groups may be thickened by treatment with multifunctional primary or secondary alcohol which may, prior to treatment, have been esterified with a weaker acid than the acid employed for purposes of performing the hydrolysis.Type: GrantFiled: May 1, 1990Date of Patent: January 14, 1992Assignee: Ceskoslovenska Akademie VedInventors: Jiri Sulc, Zuzana Krcova
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Patent number: 5076851Abstract: A mixed gypsumless Portland cement of high initial and long-lasting strengths which contains 60-96.7 weight percent gypsumless Portland cement clinker with the specific surface of 350-550 m.sup.2 /kg and 3-40 weight percent of ground latently hydraulic matter, such as granulated blast-furnace slag, light ash, and the like, which two components have been ground in the presence of 0.01-0.1 weight percent of a liquid milling admixture, advantageously with a synthetic surface active matter with wetting properties, and containing 0-20 weight percent of fine amorphous SiO.sub.2 and/or 0.1-3 weight percent sulphonated polyelectrolyte or ligninsulphonate and 0.5-6 weight percent alkaline carbonate, hydrogen carbonate, or alkaline hydroxide.Type: GrantFiled: May 11, 1990Date of Patent: December 31, 1991Assignee: Ceskoslovenska Akademie VEDInventors: Frantisek Skovara, Pius Durovec, Bohumil Cernovsky, Tomas Vsetecka, Jaroslav Hrazdira, Zdenek Kadlec
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Patent number: 5059220Abstract: Highly selective membranes for the separation of mixtures He/N.sub.2 and O.sub.2 /N.sub.2, which have suitable mechanical properties and high permeability are dislcosed. They consist of a polymeric porous base from poly-2,6-dimethyl-1,4-phenyleneoxide and a polymeric selective layer formed from polyamidoimide of the general formula I, where R= ##STR1## and n=140-220 ##STR2## or from an interpolymeric equimolar complex of PAI-1 with polyvinylpyrrolidone, or from an aromatic polyimide of the general formula II, where X is --O-- or ##STR3## and n=150-230 ##STR4## or of the general formula III, where n=150-240 ##STR5## or from polymeric imides of the general formula IV, where R=H or CH.sub.3 ##STR6## or also from their copolymers with styrene, methyl methacrylate, methyl acrylate, and dimethylaminoethyl methacrylate. A method for the preparation of composite polymeric membranes consists of saturation of the porous base from poly-2,6-dimethyl-1,4-phenyleneoxide with an organic solvent inert to it, e.g. with C.sub.Type: GrantFiled: November 15, 1989Date of Patent: October 22, 1991Assignees: Ceskoslovenska Akademie ved, Akademija Nauk SSSRInventors: Miroslav Bleha, Jan Schauer, Jan Lokaj, Galina A. Polockaja, Jurij P. Kuznecov, Kira A. Romaskova
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Patent number: 5037883Abstract: A polymeric drug comprising an inert synthetic polymeric carrier combined through aminoacid or peptide spacers with a bioactive molecule, a targeting moiety, and an optional cross-linkage, comprises:(a) 5.0 to 99.7 mol % of units derived from N-(2-hydroxypropyl)methacrylamide,(b) 0.2 to 20.0 mol % of units derived from an N-methylacrylcylated peptide, the peptide groups being bound to a bioactive moiety,(c) 0.1 to 94.8 mol % of units derived from N-methacrylamide, N-methacrylic acid or an N-methacrylolated aminoacid or peptide, to which are bound a determinant capable of interacting with specific receptors on cell surfaces,(d) optionally, 0 to 5 mol % of units derived from an N-methacryloylated peptide, the peptide groups being bound to a linking group which is similarly to a similar peptide group attached to another polymer chain, and(e) optionally, as a bioassay label, 0 to 2 mol % units derived from N-methyacryloylated tyrosinamide.Type: GrantFiled: November 17, 1989Date of Patent: August 6, 1991Assignees: Ceskoslovenska Akademie Ved, Carlton Medical Products LimitedInventors: Jindrich Kopecek, Pavla Rejmanova, Jiri Strohalm, Karel Ulbrich, Blanka Rihova, Vladimir Chytry, John B. Lloyd, Ruth Duncan
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Patent number: 5011611Abstract: Furfural is separated from a dilute aqueous solution by contacting the solution with a polymer adsorbent which comprises porous crosslinked copolymers of styrene and derivatives thereof, having an internal surface area greater than 30 m.sup.2 /g and subsequently desorbing furfural from the adsorbent through contact with an alcohol containing from 1 to 3 carbon atoms.Type: GrantFiled: December 15, 1989Date of Patent: April 30, 1991Assignee: Ceskoslovenska akademie vedInventors: Karel Jerabek, Karel Setinek, Frantisek Kastanek
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Patent number: 5002570Abstract: An intraocular hydrogel lens with shape memory swelling in water or in isotonic solution, as is physiologic saline, which is deformed before implantation into a shape suitable for operative insertion, for example, into the shape of a rod, is made, at least in part, from a crosslinked synthetic hydrogel containing acid and/or basic groups.Type: GrantFiled: December 7, 1989Date of Patent: March 26, 1991Assignee: Ceskoslovenska akademie vedInventors: Jiri Sulc, Zuzana Krcova