Abstract: A disposable syringe with protection against reuse is proved. The syringe includes a cylinder with an injection nozzle and a piston that has a piston section facing the injection nozzle, a piston rod and an actuation section facing away from the piston section, wherein the piston rod has a latching section with a shoulder that is provided in or on the piston rod and runs radially inward, the cylinder has a counter-latching section protruding inward, and the piston has at least one predetermined breaking point in such a way that when the piston rod is introduced into the cylinder the counter-latching section engages behind the shoulder to lock it and counteracts removal the piston rod from the cylinder, and wherein the predetermined breaking point is designed such that it breaks when pulling on the actuation section.