Abstract: The object of the invention is a novel sensitization process for antigen-presenting cells, novel means for implementing the process and novel membrane vesicles possessing immunogenic potency. The invention relates in particular to texosomes (vesicles derived from tumor cells) and dexosomes (vesicles derived from dendritic cells loaded or not with antigens), and their use for the vectorization and presentation of antigens in vitro or in vivo as well as in methods or compositions for the treatment of cancers and infectious, parasitic or autoimmune diseases in particular.
Type:
Grant
Filed:
July 2, 2003
Date of Patent:
December 1, 2009
Assignees:
Cetre National de la Recherche Scientifique, Institute Curie, Institute Gustave Roussy
Inventors:
Laurence Zitvogel, Graça Raposo, Armelle Regnault, Sebastian Amigorena