Patents Assigned to Cetus Oncology
  • Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom
    Patent number: 5241078
    Abstract: This invention discloses heterobifunctional coupling agents for making a wide array of molecular conjugates. The agents contain a sterically hindered thiol, linked through a spacer arm to a second group reactive toward nucleophiles such as 1.degree. and 2.degree. amines or reactive thiols that are present on biological and organic materials. The coupling agents are useful for making conjugates containing a sterically hindered linkage.
    Type: Grant
    Filed: February 14, 1992
    Date of Patent: August 31, 1993
    Assignee: Cetus Oncology
    Inventors: Margaret Moreland, I. Lawrence Greenfield, Danute E. Nitecki